Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir

Journal of Virology

Volumn 74, Issue 2, 2000, Pages 684-692

  Gustafson, Erik A ^a,b   Schinazi, Raymond F ^c   Fingeroth, Joyce D ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DERIVATIVE; DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYGUANOSINE DERIVATIVE; GANCICLOVIR; GLUTATHIONE TRANSFERASE; PHOSPHOTRANSFERASE; THYMIDINE; THYMIDINE DERIVATIVE; THYMIDINE KINASE; ZIDOVUDINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN HERPESVIRUS 8; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CELL LINE; DEOXYRIBONUCLEOSIDES; DIPHOSPHATES; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HUMANS; NUCLEOSIDE-PHOSPHATE KINASE; OPEN READING FRAMES; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; THYMIDINE KINASE; TRITIUM; ZIDOVUDINE;

EID: 0033986103     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.2.684-692.2000     Document Type: Article

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