Perinatal cocaine exposure impairs myocardial β-adrenoceptor signaling in the neonatal rat

Anesthesia and Analgesia

Volumn 90, Issue 1, 2000, Pages 50-56

  Sun, Lena S ^a,b  

^a Columbia University ^*  (United States)

^b Ph 5 544 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; COCAINE; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; IMMUNOBLOTTING; LIGAND BINDING; NEWBORN; NONHUMAN; PERINATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0033985762     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200001000-00012     Document Type: Article

References (26)

1. Glantz JC, Woods JR. Cocaine, heroin, and phencyclidine: obstetric perspectives. Clin Obstet Gynecol 1993;36:279-301.
2. Forman R, Klein J, Barks J, et al. Prevalence of fetal exposure to cocaine in Toronto, 1990-1991. Clin Invest Med 1994;17:206-11.
3. Mehta SK, Finkelhor RS, Anderson RL, et al. Transient myocardial ischemia in infants prenatally exposed to cocaine. J Ped 122:945-9, 1993.
4. Van de Bor M, Walther FJ, Ebrahimi M. Decreased cardiac output in infants of mothers who abused cocaine. Pediatrics 1990;85:30-2.
5. Geggel RL, McInerny J, Estes NAM. Transient neonatal ventricular tachycardia associated with maternal cocaine use. Am J Cardiol 1989;5:383-4.
6. Akbari HM, Azmitia EC. Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure. Dev Brain Res 1992;66:277-81.
7. Meyer JS, Dupont SA. Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity. Brain Res 1993; 608:129-37.
8. Henderson MG, McConnaughey MM, McMillen BA. Long-term consequences of prenatal exposure to cocaine or related drugs: effects on rat brain monoaminergic receptors. Brain Res Bull 1991;26:941-5.
9. Lindemann JP, Watanabe A. Mechanisms of adrenergic and cholinergic regulation of myocardial contractility. In: Sperelakis, N, ed. Physiology and pathophysiology of the heart. 2nd ed. New York: Kluver Academic Publishers, 1989;423-52.
10. oα in discrete regions of rat brain. J Neurochem 1990;55:1079-82.
11. Striplin CD, Kalivas PW. Robustness of G protein changes in cocaine sensitization shown with immunoblotting. Synapse 1993;14:10-5.
12. Terwilliger RZ, Beitner-Johnson D, Sevarino KA, et al. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 1991;548:100-10.
13. o proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. J Neurosci 1994;14:6239-47.
14. Spear LP, Frambes NA, Kirstein CL. Fetal and maternal brain and plasma levels of cocaine and benzoylecgonine following chronic subcutaneous administration of cocaine during gestation in rats. Psychopharmacology 1989;97:427-31.
15. Sun LS, Du F, Quaegebeur JM. Upregulation of right ventricular β adrenoceptors in tetralogy of Fallot patients with paroxysmal hypoxic spells. Pediatr Res 1997;42:12-6.
16. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
17. Scatchard G. The attraction of proteins for small molecules and ions. Ann N Y Acad Sci 1949;51:660-72.
18. Zar JH. Biostatistical analysis. Englewood Cliffs, NJ: Prentice-Hall, 1983.
19. Zeiders JL, Seidler EJ, Iaccarino G, et al. Ontogeny of cardiac β-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor-G protein transduction rather than eliciting uncoupling. J Mol Cell Cardiol 1999;31:413-23.
20. Unterwald EM, Cox BM, Kreek MJ, et al. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse 1993;15:33-8.
21. Przewlocka B, Lason W, Prezewlocki R. The effect of chronic morphine and cocaine administration on the Gs and Go protein messenger RNA levels in the rat hippocampus. Neuroscience 1994;63:1111-6.
22. Farfel GM, Kleven MS, Woolverton WL, et al. Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey. Brain Res 1992;578:235-43.
23. Banerjee SP, Sharma VK, Kung-Cheung LS, et al. Cocaine and d-amphetamine induce changes in central β-adrenoceptor sensitivity: effects of acute and chronic drug treatment. Brain Res 1979;175:119-30.
24. Choi WS, Ronnekleiv OK. Effects of in utero cocaine exposure on the expression of mRNAs encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain Res 1996;96:249-60.
25. 1 dopamine receptor function in rat nucleus accumbens and striatum. Brain Res 1992;573:331-5.
26. 1 dopamine receptor-mediated activation of striatal Gs proteins. J Pharmacol Exp Ther 1995; 273:492-8.