Isolation of iso-grayanotoxin II from leaves of Leucothoe grayana MAX. Its X-ray crystallographic analysis and acute toxicity in mice

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 1, 2000, Pages 142-144

  Terai, Tadamasa ^a   Araho, Daisuke ^a   Osakabe, Kanehiro ^a   Katai, Masaaki ^a   Narama, Isao ^b   Matsuura, Tetsuro ^b   Katakawa, Jun'ichi ^b   Tetsumi, Tadahiro ^b   Sato, Mamoru ^c  

^a OSAKA INSTITUTE OF TECHNOLOGY   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Iso grayanotoxin 11; Lethal dosage; Leucothoe grayana MAX.; X ray analysis

Indexed keywords

GRAYANOTOXIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; LETHAL DOSE; MALE; MOUSE; NONHUMAN; PLANT LEAF; X RAY CRYSTALLOGRAPHY;

EID: 0033985491     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.142     Document Type: Article

References (14)

1. Miyajima S., Takei I., J. Agric. Chem. Jpn., 10, 1093-1103 (1934).
2. Kakisawa H., Kozima T., Yunai M., Nakanishi K., Tetrahedron, 21, 3091-3104 (1965).
3. Iwasa J., Kumazawa Z., Nakajima M., Agric. Biol. Chem., 25, 782 801 (1961).
4. Hikino H., Ogura M., Ohta T., Takemoto T., Chem. Pharm. Bull., 18, 1071-1073 (1970).
5. Matsutani T., Seyama I., Narahashi T., Iwasa J., Pharmacol. Exp. Ther., 217, 812-819 (1981).
6. Kaiya T., Sakakibara J., Review of GTXs: Nagoyashiritsudaigaku Kenkyuunenpo, 30, 1 (1982).
7. Terai T., Nippon Kagaku Kaishi, 1988, 835.
8. Terai T., Chem. Pharm. Bull., 44, 1245-1247 (1996).
9. Hikino H., Ohta T., Ogawa M., Ohizumi Y., Konno C., Takemoto T., Toxicol. Appl. Pharmacol., 35, 303-310 (1976).
10. int) 1540 (0.016).
11. Sheldric G. M., "Program for the Solution of Crystal Structures," University of Gottingen, Germany, 1986.
12. Ashida T., "The Universal Crystallographic Computing System-Osaka," The Computer Center, Osaka University, Japan, 1979.
13. "International Tables for X-ray Crystallography," Vol. IV, The Kynoch Press, Birmingham, 1974.
14. Stewart R. F., J. Chem. Phys., 42, 3175-3187 (1965).