Novel intramolecular radical Ar-C glycosylation-lactonization reaction in the transformation of capuramycin

Heterocycles

Volumn 52, Issue 1, 2000, Pages 133-136

  Hotoda, Hitoshi ^a   Daigo, Makiko ^a   Takatsu, Toshio ^a   Muramatsu, Akiko ^a   Kaneko, Masakatsu ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CAPURAMYCIN DERIVATIVE; LACTONE DERIVATIVE; R 115381; R 116022; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENTEROCOCCUS FAECALIS; GLYCOSYLATION; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

EID: 0033985144     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-99-S46     Document Type: Article

References (7)

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2. H. Yamaguchi, S. Sato, S. Yoshida, K. Takada, M. Itoh, H. Seto, and N. Otake, J. Antibiot., 1986, 39, 1047; H. Seto, N. Otake, S. Sato, H. Yamaguchi, K. Takada, M. Itoh, H. S. M. Lu, and J. Clardy, Tetrahedron Lett., 1988, 29, 2343.
3. M. J. Robins, J. S. Wilson, and F. H. Hansske, J. Am. Chem. Soc., 1983, 105, 4059.
4. D. H. R. Barton and S. McCombie, J. Chem. Soc., Perkin Trans. 1, 1975, 1574.
5. + Δppm =-3.7.
6. Informative C-H long-range couplings for R-115381 (A) and 5 (B) are as follows: (formula presented)
7. + Δppm = -2.9.