Efficient enantioselective synthesis of C(α)-methyl aspartic acid and 3-amino-3-methylpyrrolidin-2-one

Synthesis

Volumn , Issue 1, 2000, Pages 135-138

  Sasaki, Hiroshi ^a   Carreira, Erick M ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Amino acids; Asymmetric synthesis; Pyrazolines

Indexed keywords

ASPARTIC ACID DERIVATIVE; PYRROLIDINE DERIVATIVE;

ARTICLE; ENANTIOMER; REACTION ANALYSIS; REDUCTION; SYNTHESIS;

EID: 0033983413     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-6240     Document Type: Article

References (33)

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32. 2 solution was concentrated and purified by column chromatography on silica gel (hexanes/ EtOAc = 60/40) to afford (1R)-2,10-camphorsultam (90.4 mg, 0.420 mmol, 42%).
33. The THF solution was concentrated and purified by column chromatography on silica gel (hexanes/EtOAc = 60/40) to afford (1R)-2,10-camphorsultam (69.2 mg, 0.321 mmol, 64%).