Monte Carlo simulations of light distributions in an embedded tumour model: Studies of selectivity in photodynamic therapy

Lasers in Medical Science

Volumn 15, Issue 1, 2000, Pages 49-56

  De Jode, M L ^a,b  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Light transport in tissue; Monte Carlo simulation; Photodynamic therapy; Selectivity

Indexed keywords

ARTICLE; BREAST CARCINOMA; LIGHT EXPOSURE; LIVER TUMOR; MODEL; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; SYSTEM ANALYSIS; TISSUE DISTRIBUTION; TISSUE INJURY;

EID: 0033983094     PISSN: 02688921     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101030050047     Document Type: Article

References (18)

1. 14C]hematoporphyrin derivative distribution in malignant and normal tissue. Cancer Res 1979;39:146-51
2. Moan J. Properties for optimal PDT sensitizers. J Photochem Photobiol 1990;B5:521-4
3. Svaasand LO, Potter WR. The implications of photobleaching for photodynamic therapy. In: Henderson BW, Dougherty TJ (eds) Photodynamic Therapy. New York: Marcel Dekker, 1992:369-85
4. Wilson BC, Adam G. A Monte Carlo model for the absorption and flux distributions of light in tissue. Med Phys 1983;10:824-30
5. Prahl SA. Light transport in tissue. PhD Dissertation University at Texas at Austin 1988:15-40
6. Jacques SL, Wang L. Monte Carlo modeling of light transport in tissue. In Welch AJ, van Gemert MJC (eds) Optical-Thermal Response of Light Irradiated Tissue. New York: Plenum, 1995:73-101
7. Henyey LG, Greenstein JL. Diffuse radiation in the galaxy. Astrophys J 1941;93:70-83
8. Jacques SL, Alter CA, Prahl SA. Angular dependence of HeNe laser light scattering by human dermis. Lasers Life Sci 1987;1:309-33
9. van Hillegersberg R, Pickering JW, Aalders M, Beek JF. Optical properties of rat liver and tumour at 633 nm and 1064 nm: Photofrin enhances scattering. Lasers Surg Med 1993;13:31-9
10. Peters VG, Wyman DR, Patterson MS, Frank GL. Optical properties of normal and diseased human breast tissues in the visible and near infra-red. Phys Med Biol 1990;35:1317-34
11. Patterson MS, Wilson BC, Wyman DR. The propagation of optical radiation in tissue. II: optical properties of tissues and resulting fluence distributions. Lasers Med Sci 1991;6:380-90
12. Jacques SL. Light distributions from point, line and plane sources for photochemical reactions and fluorescence in turbid biological tissues. Photochem Photobiol 1998;67:23-32
13. Patterson MS, Wilson BC, Graff R. In vivo tests of the concept of photodynamic dose in normal rat liver photosensitised by aluminium chlorosulphated phthalocyanine. Photochem Photobiol 1990;51:343-9
14. Wilson BC, Patterson MS, Burns DM. Effect of photosensitizer concentration in tissue on the penetration depth of photoactivating light. Lasers Med Sci 1986; 1:235-44
15. Grahn MF, McGuiness A, Benzie R, Boyle R, de Jode ML, Dilkes MG et al. Intracellular uptake, absorption spectrum and stability of the bacteriochlorin photosensitiser 5,10,15,20-tetrakis(m-hydroxyphenyl) bacteriochlorin (mTHPBC). Comaprison with 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin (mTHPC). J Photochem Photobiol B 1997;37:261-6
16. Moan J. Effect of photobleaching of porphyrin photosensitizers during photodynamic therapy. Cancer Lett 1986; 33:45-53
17. Wilson BC, Patterson MS, Lilge L. Implicit and explicit dosimetry in photodynamic therapy: a new paradigm. Lasers Med Sci 1997;12:182-99
18. Ris H-B, Altermatt HJ, Nachbur B, Stewart JCM, Wang Q, Lim CK et al. Effect of drug light interval on photodynamic therapy with meta-tetrahydroxyphenyl-chlorinin malignant mesothelioma. Int J Cancer 1993; 53:141-6