Manual versus image analysis estimation of PCNA in breast carcinoma

Analytical and Quantitative Cytology and Histology

Volumn 22, Issue 1, 2000, Pages 11-16

  Francis, Issam M ^a,b   Adeyanju, Moses O ^a,b   George, Sara S ^a,b   Junaid, Thamradeen A ^a,b   Luthra, Usha K ^a,b  

^a KUWAIT UNIVERSITY   (Kuwait)

^b MUBARAK AL KABEER HOSPITAL   (Kuwait)

Author keywords

Breast neoplasms; CAS 200; Computer assisted; Image analysis; Proliferating cell nuclear antigen

Indexed keywords

CYCLINE; PARAFFIN;

ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CELL PROLIFERATION; COMPUTER ASSISTED DIAGNOSIS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ALGORITHMS; AUTOMATIC DATA PROCESSING; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; DIAGNOSIS, COMPUTER-ASSISTED; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; PARAFFIN EMBEDDING; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; REPRODUCIBILITY OF RESULTS;

EID: 0033983021     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Battesby S, Anderson TJ: Correlation of proliferative activity in breast tissue using CNA/cyclin (lett). Hum Pathol 1990; 21:781
2. Caulet-Maugendre S, Patey M, Granier E, Joundi A, Gentile A, Caulet T: Quantitative analysis of cellular proliferative activity in 35 T-cell non-Hodgkin's lymphomas: Use of proliferating cell nuclear antigen and Ki-67 (MIB-1) antibodies and nucleolar organizer regions. Analyt Quant Cytol Histol 1996; 18:337-344
3. Faccioli S, Cavicchi O, Caliceti U, Rinaldi Ceroni A, Chieco P: Cell proliferation as an independent predictor of survival for patients with advanced nasopharyngeal carcinoma. Mod Pathol 1997;10:884-894
4. Khurana KK, Truong LD, Verani RR: Image analysis of proliferation cell nuclear antigen expression and immunohistochemical profiles in renal cell carcinoma associated with acquired cystic kidney disease: Comparison with classic renal cell carcinoma. Mod Pathol 1998;11:339-346
5. Kirkegaard LJ, DeRose PB, Yao B, Cohen C: Image cytometric measurement of nuclear proliferation markers (MIB-1, PCNA) in astrocytomas: Prognostic significance. Am J Clin Pathol 1998;109:69-74
6. Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS, Danielsen HE, Pettersen EO, Sobrinho-Simoes M, Nesland JM: Synovial sarcoma: Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers. Anal Cell Pathol 1998;16:45-62
7. Miller K: Immunocytochemical techniques. In Theory and Practice of Histological Techniques. Edited by JD Bancroft, A Stevens. Edinburgh, Churchill Livingstone, 1996, pp 435-488
8. Sallinen P, Haapasalo H, Kerttula T, Rantala I, Kalimo H, Collan Y, Isola J, Helin H: Sources of variation in the assessment of cell proliferation using proliferating cell nuclear antigen immunohistochemistry. Analyt Quant Cytol Histol 1994;16:261-268
9. Schwartz BR, Pinkus S, Toder M, Weinber DS: Cell proliferation in non-Hodgkin's lymphoma: Digital image analysis of Ki-67 staining. Am J Pathol 1998;134:327-336
10. Siitonen SM, Isola JJ, Rantala IS, Helin HJ: Intratumor variation in cell proliferation in breast carcinoma as determined by antiproliferating cell nuclear antigen monoclonal antibody and automated image analysis. Am J Clin Pathol 1993; 99:226-231
11. Striepecke E, Handt S, Weis J, Koch A, Cremerius U, Reineke T, Bull U, Schroder JM, Zang KD, Bocking A: Correlation of histology, cytogenetics and proliferation fraction (Ki-67 and PCNA) quantitated by image analysis in meningiomas. Pathol Res Pract 1996;192:816-824
12. Tajima Y, Kato K, Utsumi N, Hosoi K: Computer-aided image analysis applied to immunogold-silver staining: Evaluation of proliferating cell nuclear antigen (PCNA)-reactive sites in paraffin sections. Histochemistry 1994;102:177-181
13. Veltri RW, Partin AW, Epstein JE, Marley CM, Miller CM, Singer DS, Patton KP, Criley SR, Coffey DS: Quantitative nuclear morphometry, Markovian texture descriptors, and DNA content captured on a CAS-200 Image analysis system, combined with PCNA and HER-2/neu immunohistochemistry for prediction of prostate cancer progression. J Cell Biochem (suppl) 1994;19:249-258
14. Weinberg DS: Image Analysis: A Primer for Pathologists. New York, Raven Press, 1994, pp 235-260
15. Wells SJ, DeRose PB, Cohen C: Image cytometric comparison of proliferating cell nuclear antigen and MIB-1 staining in hepatocellular carcinoma and adjacent liver tissue. Cytometry 1996;26:198-203