Elevated levels of Ca(II) modulate the activity and inhibition of serine proteases: Implication in the mechanism of apoptosis

Cell Biochemistry and Function

Volumn 18, Issue 1, 2000, Pages 59-66

  Adebodun, Foluso ^a   Scott, Corey E ^a   Cunningham, Connell ^a   Bustamante, Pedro M ^a   Bradshaw, Ayanna ^a   Ping, Liu ^a   Williams, Karen R ^a  

^a NORTH CAROLINA A AND T STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Effects of calcium ions; Enzyme inhibition; Glucocorticoid action; Leukemic cells; Serine proteases

Indexed keywords

CALCIUM ION; DEXAMETHASONE; MAGNESIUM ION; POTASSIUM ION; SERINE PROTEINASE; SODIUM ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

APOPTOSIS; CALCIMYCIN; CALCIUM; CHYMOTRYPSIN; DEXAMETHASONE; EDETIC ACID; ENZYME STABILITY; IONOPHORES; MAGNESIUM; POTASSIUM; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SODIUM; TRYPSIN; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0033982662     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0844(200001/03)18:1<59::AID-CBF850>3.0.CO;2-O     Document Type: Article

References (40)

1. Arends, M. J. and Wyllie, A. H. (1991). Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol., 32, 223-254.
2. Raff, M. C. (1992). Social controls on cell survival and cell death. Nature, 356, 397-399.
3. Fesus, L., Davies, P. J. A. and Piacentini, M. (1991). Apoptosis: molecular mechanisms in programmed cell death. Eur. J. Cell Biol., 56, 170-177.
4. Williams, G. T. (1991). Programmed cell death: Apoptosis and oncogenesis. Cell, 65, 1097-1098.
5. Thompson, C. B. (1995). Apoptosis in pathogenesis and treatment of disease. Science, 267, 1456-1462.
6. Kerr, J. F. R., Wyllie, A. H. and Currie, A. R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 25, 239-257.
7. Wyllie, A. H. (1980). Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature, 284, 555-556.
8. Sellins, K. S. and Cohen, J. J. (1987). Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J. Immunol., 139, 3199-3206.
9. Goldstein, P., Ojcius, D. M. and Young, J. D. (1991). Cell death mechanism and the immune system. Immunol. Rev., 121, 29-65.
10. Cohen, J. J. and Duke, R. C. (1984). Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol., 132, 38-42.
11. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. and Owen, J. J. T. (1989). Antibodies to CD3/T cell receptor complex induce death by apoptosis in immature T-cell in thymic cultures. Nature, 337, 181-184.
12. Harmon, J. M., Norman, M. R., Fowlkes, B. J. and Thompson, E. B. (1979). Dexamethasone induces irreversible G1 arrest and death of human lymphoid cell line. J. Cell. Physiol., 98, 267-278.
13. Bansal, N., Houle, A. and Melnykovych, G. (1991). Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. FASEB J., 5, 211-216.
14. Colbert, R. A. and Young, D. A. (1986). Glucocorticoid-induced messenger ribonucleic acids in rat thymic lymphocytes: rapid primary effects specific for glucocorticoids. Endocrinology, 119, 2598-2605.
15. 31P Nuclear magnetic resonance studies of growth inhibition and dexamethasone resistance in human leukemic cells. Cancer Lett., 51, 157-162.
16. 13C NMR studies of glucose metabolism in human leukemic CEM-C7 and CEM-C1 cells. Magn. Reson. Med., 23, 356-366.
17. Gerschenson, L. E. and Rotello, R. (1992). Apoptosis: A different type of cell death. FASEB J., 6, 2450-2455.
18. 19F-NMR studies of changes in membrane potential and intracellular volume during dexamethasone induced apoptosis in human leukemic cell lines. J. Cell. Physiol., 154, 199-206.
19. 31P NMR characterisation of cellular metabolism during dexamethasone induced apoptosis in human leukemic cell lines. J. Cell. Physiol., 158, 180-186.
20. Adebodun, F. and Post, J. F. M. (1995). Role of intracellular free Ca(II) and Zn(II) in dexamethasone induced apoptosis and dexamethasone resistance in human leukemic cell lines. J. Cell. Physiol., 163, 80-86.
21. 2+-dependent mechanisms of cytotoxicity and programmed cell death. Toxicology Lett., 64/65, 357-364.
22. Kaiser, N. and Edelman, I. S. (1977). Calcium dependence of glucocorticoid-induced lymphocytolysis. Proc. Natl. Acad. Sci. (USA), 74, 638-642.
23. McConkey, D. J., Hartzell, P., Nicotera, P. and Orrenius, S. (1989). Calcium-activated DNA fragmentation kills immature tymocyces. FASEB J., 3, 1843-1849.
24. 2+ concentration. Arch. Biochem. Biophys., 269, 365-370.
25. Kagaya, S., Kitanaka, C., Noguchi, K., Mochizuki, T., Sugiyama, A., Asai, A., Yasuhara, N., Eguchi, Y., Tsujimoto, Y. and Kuchino, Y. (1997). A functional role for death proteases in s-myc-and c-myc-mediated apoptosis. Mol. Cell. Biol., 17, 6736-6745.
26. He, J., Whitacre, C. M., Xue, L., Berger, N. A. and Oleinick, N. L. (1998). Protease activation and cleavage of poly(ADP-ribose) polymerase: An integral part of apoptosis in response to photodynamic treatment. Cancer Res., 58, 940-946.
27. Hara, S., Halicka, H. D., Bruno, D. S., Gong, J., Traganos, F. and Darzynkiewicz, Z. (1996). Effects of protease inhibitors on early events of apoptosis. Exp. Cell Res., 223, 372-384.
28. Lumelsky, N. L. and Schwartz, B. S. (1996). Protease inhibitors induce specific changes in protein tyrosine phosphorylation that correlate with inhibition of apoptosis in myeloid cells. Cancer Res., 56, 3909-3924.
29. Marcelli, M., Cunningham, G. R., Haidacher, S. J., Padayahy, S. J., Sturgis, L., Kagan, C. and Denner, L. (1998). Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Rev., 58, 76-83.
30. Martin, S. J. and Green, D. R. (1995). Protease activation during apoptosis: Death by thousand cuts? Cell, 82, 349-352.
31. Wilson, K. P., Black, J. F., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A. and Livingston, D. J. (1994). Structure and mechanism of interleukin-1β converting enzyme. Nature (Lond.), 370, 270-275.
32. Bruno, S., Del-Bino, G., Lassota, P., Giaretti, W. and Darzynkiewicz, Z. (1992). Inhibitors of proteases prevent endonucleosis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Leukemia (Baltimore), 6, 1113-1120.
33. Epstein, M., Reuben, J. and Levitzki, A. (1977). Calcium binding site of trypsin as probed by lanthanides. Biochemistry, 16, 2449-2457.
34. Adebodun, F. and Jordan, F. (1989). Multinuclear magnetic resonance studies on the calcium (II) binding site in trypsin, chymotrypsin, and subtilisin. Biochemistry, 28, 7524-7531.
35. 2+ to trypsinogen and its relation to the mechanism of activation. Biochem. Biophys. Res. Commun., 28, 390-394.
36. Laskowski, M. (1967). Trypsinogen and trypsin. Method Enzymol., 2, 26-36.
37. Neurath, H. (1986). The versatility of proteolytic enzymes. J. Cell. Biochem., 32, 35-49.
38. Sipos, T. and Merkel, J. R. (1970). An effect of calcium ions on the activity, heat stability, and structure of trypsin. Biochemistry, 9, 2766-2775.
39. Darnall, D. W., Abbott, F., Gomez, J. E. and Birnbaum, R. E. (1976). Fluorescence energy transfer measurements between the calcium binding site and the specificity pocket of bovine trypsin using lanthanide probes. Biochemistry, 15, 5017-5023.
40. Bier, M. and Nord, F. F. (1951). On the mechanism of enzyme action XLVI: The effects of certain ions on crystalline trypsin and re-investigation of its isoelectric point. Arch. Biochem. Biophys., 33, 320-332.