Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction

American Heart Journal

Volumn 139, Issue 1 I, 2000, Pages 10-14

  McKinlay, S ^a  

^a NEW ENGLAND RESEARCH INSTITUTES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM SULFATE;

ACUTE HEART INFARCTION; AGED; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; HEART LEFT BUNDLE BRANCH BLOCK; HEART VENTRICLE ARRHYTHMIA; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REPERFUSION INJURY; SHOCK; ST SEGMENT ELEVATION;

EID: 0033982297     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(00)90302-8     Document Type: Article

References (23)

1. De Vreede JJM, Gorgels APM, Verstraaten GMP, Vermeer F, Dassen WRM, Welens HJJ. Did prognosis after acute myocardial infarction change during the past 30 years? A meta-analysis. J Am Coll Cardiol 1991;18:698-706.
2. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of mortality and major morbidity results from all randomized trials of more than 1000 patients. Lancet 1994;343:311-22.
3. Rogers W, Bowlby L, Chandra N, et al. Treatment of myocardial infarction in the United States (1990-1993): observations from the National Registry of Myocardial Infarction. Circulation 1994;90:2103-14.
4. White HD, Barbash GI, Califf RM, et al for the GUSTO-I Investigators. Age and outcome with contemporary thrombolytic therapy: results from the GUSTO-I trial. Circulation 1996;94:1826-33.
5. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) investigators. A comparison of reteplase with alteplase for acute myocardial infarction. New Engl J Med 1997;337:1118-23.
6. The continuous infusion versus double-bolus administration of alteplase (COBALT) investigators. A comparison of continuous infusion of alteplase with double-bolus administration for acute myocardial infarction. New Engl J Med 1997;337:1124-30.
7. Woods KL. Possible pharmacologic actions of magnesium in acute myocardial infarction. Br J Clin Pharmacol 1991;32:3-10.
8. Du Toit EF, Opie LH. Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at reperfusion. Circ Res 1992;70:960-7.
9. Ravn HB, Moeldrup U, Brookes CIO, et al. Intravenous magnesium reduces infarct size after ischemia/reperfusion injury combined with a thrombogenic lesion in the left anterior descending artery. Arterioscler Thromb Vasc Biol 1999;19:569-74.
10. Teo KK, Yusuf S, Collins R, Held PH, Peto R. Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomized trials. BMJ 1991;303:1499-503.
11. Woods KL, Fletcher S, Roffe C, Haider Y. Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1992;339:1553-8.
12. ISIS-4 Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected myocardial infarction. Lancet 1995;345:669-85.
13. Antman EM. Randomized trials of magnesium in acute myocardial infarction: big numbers do not tell the whole story. Am J Cardiol 1995;75:391-3.
14. Antman EM. Magnesium in acute myocardial infarction: overview of available evidence. Am Heart J 1996;132:487-94.
15. Woods KL. Mega-trials and management of acute myocardial infarction. Lancet 1995;346:611-4.
16. Shechter M, Hod H, Kaplinsky E, Chouraqui P, Rabinowitz B. Magnesium as alternative therapy in patients with acute myocardial infarction who are not candidates for thrombolytic therapy. Am J Cardiol 1995;75:321-3.
17. Woods KL, Fletcher S. Magnesium and myocardial infarction. Lancet 1994;343:1565-6.
18. Christensen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation 1995;92:2617-21.
19. Herzog WR, Schlossberg ML, MacMurdy KS, et al. Timing of magnesium therapy affects experimental infarct size. Circulation 1995;92:2622-6.
20. DeWood MA, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. New Engl J Med 1980;303:897-902.
21. Ware JH, Antman EM. Equivalence trials. N Engl J Med 1997;337:1159-61.
22. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979;35:549-56.
23. Lan KK, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983;70:659-67.