Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats

Pharmacology

Volumn 60, Issue 1, 2000, Pages 9-12

  Usta, Coşkun ^a   Şadan, Gülay ^a  

^a AKDENIZ UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Diabetes mellitus, experimental; Phosphodiesterase inhibitors; Trachea

Indexed keywords

AMRINONE; CARBACHOL; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; STREPTOZOCIN DIABETES; TRACHEA MUSCLE;

EID: 0033981904     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028340     Document Type: Article

References (14)

1. Barnes PJ: Our changing understanding of asthma. Respir Med 1989;835:17-23.
2. Djukanaviç R, Roche WR, Wilson JW, et al: Inflammation in asthma. Am Rev Respir Dis 1990;142:414-457.
3. Hall IP: Isoenzyme selective phosphodiesterase inhibitors: Potential clinical uses. Br J Clin Pharmacol 1993;35:1-7.
4. Delpy E: Cardiovascular effect of a novel, potent and selective phosphodiesterase 5 inhibitor, DMPPO: In vitro and in vivo characterization. Br J Pharmacol 1996;118:1377-1384.
5. Nicholson CD, Shahid M, Bruin J, Barron E, Spiers E, Boer J, Amsterdam GM, Zaagsma J, Kelly JJ, Dent G, Giembycz MA, Barnes PJ: Characterization of ORG 20241, a combined phosphodiesterase IV/III cyclic nucleotide phosphodiesterase inhibitor for asthma. J Pharmacol Exp Ther 1995;274:678-686.
6. Solomon SS; Chiang TM, Palazzolo MR: Activation of cyclic AMP phosphodiesterase by phorbol and protein kinase C. Endocr Res 1990;16:391-402.
7. Tanaka H, Ogawa K, Tagagi, Salake T, Hidaka H: Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin Exp Pharmacol Physiol 1991;18:163-168.
8. Mano T, Iwase K, Sawai Y, Oda N, Nishida Y, Mokuno T, Itoh Y, Kotake M, Masunaga R, Nakai A: Changes of calmodulin concentration and cyclic nucleotide phosphodiesterase activities in cardiac muscle of hyper- and hypothyroid rats. J Endocrinol 1994;143:515-520.
9. Donnell JM, Banyasz T: Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats. Br J Pharmacol 1996;117:938-942.
10. Solomon SS, Palazzolo MR, Elam MB, Green S. Raghow R: Regulation of calmodulin gene expression by insulin is both transcriptional and posttranscriptional. J Lab Clin Med 1994; 124:348-358.
11. Ozansoy G, Karasu C, Altan M: The effects of acetylcholine on insulin-dependent and noninsulin-dependent diabetic rat tracheal segments. Gen Pharmacol 1993;24:159-164.
12. Ozansoy G, Karasu Ç, Özçelikay AT: The effect of oral vanadyl treatment on the reactivity of tracheal smooth muscle obtained from insulin-dependent diabetic rats. Gen Pharmacol 1993;24:115-119.
13. Cros G, Gies JP, Cahard D, Cohen P, Filipek B, Mongold JJ, Serrano JJ: Impairment of contractility associated with muscarinic supersensitivity in trachea isolated from diabetic rats: Lack of correlation with ultrastructural changes or quinuclidinyl benzylate binding to lung membranes. Mol Cell Biochem 1992; 109:181-183.
14. Mongold JJ, Cros GH, Michel A: Diabetes-induced rat tracheal segment supersensitivity to carbachol. Can J Physiol Pharmacol 1988; 66:660-662.