Effects of prenatal aflatoxin B1 exposure on behaviors of rat offspring

Toxicological Sciences

Volumn 53, Issue 2, 2000, Pages 392-399

  Kihara, Takahide ^a,d   Matsuo, Takuya ^a   Sakamoto, Michiko ^a   Yasuda, Yoshiko ^a   Yamamoto, Yoshitame ^c   Tanimura, Takashi ^b  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c SANTEN PHARMACEUTICAL CO LTD   (Japan)

^d NONE   (Japan)

Author keywords

2,3,6a ,9a tetrahydro 4 methoxycyclopenla c furo 3',2',: 4,5 furo 2, 3 h 1 benzopyran 1, 11 dione; Aflatoxin B1; Behavioral teratology; Developmental toxicity; Mycotoxin; Neurotoxicity; Prenatal exposure

Indexed keywords

AFLATOXIN B1; DIMETHYL SULFOXIDE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; LEARNING; MOTOR COORDINATION; NEWBORN; NONHUMAN; PRENATAL EXPOSURE; RAT; REFLEX; REPRODUCTION; SWIMMING;

EID: 0033981824     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.2.392     Document Type: Article

References (56)

1. Adams, J. (1986). Methods in behavioral teratology. In Handbook of Behavioral Teratology (E. P. Riley, and C. V. Vorhees, Eds.), pp. 67-97. Plenum Press, New York, London.
2. 1 injection. Exp. Pathol. 26, 163-169.
3. Altman, J., and Sudarshan, K. (1975). Postnatal development of locomotion in the laboratory rat. Anim. Beliav. 23, 896-920.
4. 1 ochratoxin A and Zearalenone. Acta Vet. Scand. 22, 524-534.
5. 0, on the chick embryo. J. Pathol. 102, 49-51.
6. 1 with guanines in different DNA sequences. Biochemistry 27, 472-481.
7. Brunner, R. L., McLean, M., Vorhees, C. V., and Butcher, R. E. (1978). A comparison of behavioral and anatomical measures of hydroxyurea induced abnormalities. Teratology 18, 379-384.
8. 1 given to pregnant rats on the liver, brain and the behaviour of their offspring. Nutr. Rep. Int. 34, 379-386.
9. 1 on the chick embryo development. Morphol. Embryol. (Bucur). 4, 309-314.
10. 1: Mutagenicity and influence on development and immunity. Environ. Mutagen. 7, 715-725.
11. 1. Nature 215, 638-639.
12. Eaton, D.L. and Gallagher, E. P. (1994) Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 34, 135-172.
13. 1 in the rat. Acta Embryol. Exp. 2, 199-201.
14. 1, induction of malformations. Arch. Pathol. 83, 53-57.
15. Gabor, M., Puscariu, F., and Deac, C. (1973). Action tératogéne des aflatoxins sur les têtards. Arch. Roum. Pathol. Exp. Microbiol. 32, 269-275.
16. 1 in the rodent embryo in vitro: Contribution of exogenous biotransformation systems to toxicity. Teratology 37, 101-111.
17. 1 generation. A contribution to transplacental carcinogenesis. J. Natl. Cancer Inst. 64, 1349-1354.
18. Grice, H. C., Moodie, C. A., and Smith, D. C. (1973). The carcinogenic potential of aflatoxin or its metabolites in rats from dams fed aflatoxin pre-and postpartum. Cancer Res. 33, 262-268.
19. Hall, C. S. (1934). Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. J. Comp. Psychol. 18, 385-403.
20. Hayes, A. W. (1981). Aflatoxins. In Mycotoxin Teratogenicity and Mutagenicity. (A.W. Hayes Ed.), pp. 44-47. CRC Press, Boca Raton.
21. Hood, R. D. (1979). Effects of mycotoxins on development. Teratological testing. In Advances in the Study of Birth Defects (T. V. N. Persaud, Ed.), Vol.2, pp. 191-210. MTP press, Lancaster.
22. Hood, R. D., and Szczech, G. M. (1983). Teratogenicity of fungal toxins and fungal-produced antimicrobial agents. In Handbook of Natural Toxins. Plant and Fungal Toxins (R. F. Keeler and A. T. Tu, Eds.), Vol. 1, pp. 201-235. Marcel Dekker, Inc., New York.
23. Hutchings, D. E. (1983). Behavioral teratology: A new frontier in neurobehavioral research. In Teratogenesis and Reproductive Toxicology (E. M. Johnson and D. M. Kochhar, Eds.), pp. 207-235. Springer-Verlag, Berlin, Heidelberg, New York.
24. IARC (1983) Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 56. International Agency for Research on Cancer, Lyon, France.
25. 1-2, 3-oxide. Mutat. Res. 179, 89-101.
26. Kaplan, M. L., and Murphy, S. D. (1972). Effect of acrylamiode on rotarod performance and sciatic nerve β-glucuronidase activity of rats. Toxicol. Appl. Pharmacol. 22, 259-268.
27. Kihara, T. (1991). Effects of the prenatal ochratoxin A exposure on behaviors of rat offspring. Acta Med. Kinki Univ. 16, 1-22.
28. Kihara, T., Matsuo, T., Sakamoto, M., Yasuda, Y., and Tanimura, T. (1995). Effects of the neonatal vitamin A exposure on behaviors of adult rats. J. Toxicol. Sci. 20, 93-101.
29. Kinnard, Jr., W. J., and Carr, C. J. (1957). A preliminary procedure for the evaluation of central nervous system depressants. J. Pharmacol. Exp. Ther. 120, 354-361.
30. LeBreton, E., Frayssinet, C., Lafarge, C., and deRecondo, A. M. (1964). Aflatoxine-Mécanisme de l'action. Food. Cosmet. Toxicol. 2, 675-677.
31. Leonard, B. E. (1983). Behavioral teratology and toxicology. In Psychopharmacology 1, Part I Preclinical Psychopharmacology (D. G. Grahame-Smioth, Ed., pp. 248-299. Excerpta Medica, Amsterdam, Oxford, Princeton.
32. 1 induced toxicity and teratogenicity in Japanese Medaka eggs (Oryzias Latipes). Toxicon. 15, 582-587.
33. Ong, T. (1975). Aflatoxin mutagenesis. Mutat. Res. 32, 35-53.
34. Panda, P. C., Sreenivasamurthy, V., and Parpia, H. A. B. (1970). Effect of aflatoxin on reproduction in rats. J. Food. Sci. Technol. 7, 20-22.
35. Pellegrino, L. J., and Altman, J. (1979). Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: A developmental study. J. Comp. Physiol. Psychol. 93, 1-33.
36. Riley, E. P., and Vorhees, C. V. (1986). Handbook of Behavioral Teratology. Plenum Press, New York, London.
37. Kodier, P. M., Reynolds, S. S., and Roberts, W. N. (1979). Behavioral consequences of interference with CNS development in the early fetal period. Teratology 19, 327-336.
38. Roll, R., Matthiaschk, G., and Korte, A. (1990). Embryotoxicity and mutagenicity of mycotoxins. J. Environ. Pathol. Toxicol. Oncol. 10, 1-7.
39. Schapiro, S., Salas, M., and Vukovich, K. (1970). Hormonal effects on ontogeny of swimming ability in the rat: Assessment of central nervous system development. Science 168, 147-151.
40. Siegel, S. (1956). Nonparametric Statistics: For the Behavioral Sciences. McGraw-Hill Book Co., Inc., New York.
41. Sokal, R. R., and Rohlf, F. J. (1973). Introduction to Biostatics. W. H. Freeman and Company, San Francisco.
42. 1: Binding to DNA in vitro and alteration of RNA metabolism in vivo. Science 151, 1539-1541.
43. 1 on rat fetus. Proc. Jpn. Assoc. Mycotoxicol. 1, 9-12.
44. Tanimura, T. (1990). Japanese perspectives on the reproductive and developmental toxicity evaluation of pharmaceuticals. J. Am. Coll Toxicol. 9, 27-37.
45. Tanimura, T. (1992). Update on the activities of the Japanese Behavioral Teratology Meeting. Congenital Anom. 32(suppl), S7-S20.
46. 1 in the mouse. Rep. Environ. Sci. Res. Instit. Kinki Univ. No. 14, 247-256.
47. Ulbrich, B. and Palmer, A. K. (1996). Neurobehavioral aspects of developmental toxicity testing. Environ. Health Perspect. 104(suppl 2), 407-412.
48. Vorhees, C. V. (1983). Fetal anticonvulsant syndrome in rats: Dose-and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. J. Pharmacol. Exp. Ther. 227, 274-287.
49. Vorhees, C. V. (1987). Dependence on the stage of gestation: Prenatal drugs and offspring behavior as influenced by different periods of exposure in rats. In Functional Teratogenesis (T. Fujii, and P. M. Adams, Eds.), pp. 39-51. Teikyo University Press, Tokyo.
50. Vorhees, C. V., Brunner, R. L., and Butcher, R. E. (1979a). Psychotropic drugs as behavioral teratogens. Science 205, 1220-1225.
51. Vorhees, C. V., Butcher, R. E., Brunner, R. L., and Sobotka, T. J. (1979b). A developmental test battery for neurobehavioral toxicity in rats: A preliminary analysis using monosodium glutamate calcium carrageenan, and hydroxyurea. Toxicol Appl. Pharmacol. 50, 267-282.
52. Walsh, R. N., and Cummins, R. A. (1976). The open-field test: A critical review. Psychol. Bull. 83, 482-504.
53. Wilson, B. J., Campbell, T. C., Hayes, A, W., and Hanlin, R. T. (1968). Investigation of reported aflatoxin production by fungi outside the Asperigillus flavus group. Appl. Microbiol. 16, 819-821.
54. 1 carcinogenesis in the rat. Cancer Res. 27, 2370-2376.
55. Wong, J. J., and Hsieh, D. P. H. (1976). Mutagenicity of aflatoxins related to thier metabolism and carcinogenic potental. Proc. Nail. Acad. Sci. USA. 73, 2241-2244.
56. 1 and metabolites to Salmonella typhimurium: Structure mutagenicity relationships and mechanisms of action. Res. Comm. Chem. Pathol. Pharmacol. 57, 55-76.