Irradiation of genetically modified plasmacytoma vaccines results in upregulation of CD80 molecule expression, IL-2 production and higher therapeutic efficacy of the vaccines

Folia Biologica

Volumn 46, Issue 1, 2000, Pages 11-15

  Simova J ^a   Reinis M ^a   Sobota, V ^a   Capkova J ^a   Bubenik J ^a   Jandlova T ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; INACTIVATED VACCINE; INTERLEUKIN 2; LIVE VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MODIFICATION; GENE EXPRESSION REGULATION; IRRADIATION; MALE; MOUSE; NONHUMAN; PLASMACYTOMA;

EID: 0033981613     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Abdel-Wahab, Z., Dar, M. M., Hester, D., Vervaert, C., Gangavalli, R., Barber, J., Darrow, T. L., Seigler, H. F. (1996) Effect of irradiation on cytokine production. MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. Cell. Immunol. 171, 246-254.
2. Bubenik, J. (1996) Genetically modified tumour vaccines carrying inserted genes for immunoregulatory molecules. Folia Biol. (Praha) 42, 295-304.
3. Bubeník, J., Šímová, J., Jandlová, T. (1990) Immunotherapy of cancer using local administration of lymphoid cells transformed by IL-2 cDNA and constitutively producing IL-2. Immunol. Lett. 23, 287-292.
4. Bubeník, J., Šímová, J., Bubeníková, D., Zeuthen, J., Indrová, M. (1995) Interleukin-2 gene therapy of residual EL-4 leukaemia potentiates the effect of cyclophosphamide pretreatment. J. Cancer Res. Clin. Oncol. 121, 39-43.
5. Čapková, J., Hašek, M., Kousalová, M., Holáň, V., Boubelík, M. (1983) Alloreactive cytotoxic anti-H-2 antibodies in sera of the syngeneically immunized C57BL/10ScSnPh, BALB/cJPh, and B10.A/SnPh mice. Folia Biol. (Praha) 29, 200-208.
6. bm25 mutation. Folia Biol. (Praha) 36, 281-290.
7. Gansbacher, B., Zier, K., Daniels, B., Cronin, K., Bannerji, R., Gilboa, E. (1992) Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J. Exp. Med. 172, 1217-1224.
8. Germain, R. N. (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76, 287-299.
9. b in B16 melanoma cells. Cancer Res. 53, 1952-1955.
10. Hersey, P. S. Z., Smith, M. J., Thomas, W. D. (1994) Expression of the co-stimulatory molecule B7 on melanoma cells. Int. J. Cancer 58, 527-532.
11. Karasuyma, H., Melchers, F. (1988) Establishment of mouse cell lines which constitutively secrete large quantities of interleukin-2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18, 97-104.
12. Kearney, J. F., Radbruch, A., Liessgang, B., Rajewsky, K. (1979) A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123, 1548-1550.
13. Klein, B., Loven, D., Lurie, H., Rakowsky, E., Nyska, A., Levin, I., Klein, T. (1994) The effect of irradiation on expression of HLA class I antigens in human brain tumours in culture. J. Neurosurg. 80, 1074-1077.
14. Morel, A., Fernandez, N., de La Coste, A., Haddada, H., Viguier, M., Polla, B. S., Antoine, B., Kahn, A. (1998) γ-Ray irradiation induces B7.1 costimulatory molecule neoexpression in various murine tumor cells. Cancer Immunol. Immunother. 46, 277-282.
15. Mochizuki, K., Hayashi, N., Kataykama, K., Hiramatsu, N., Kanto, T., Mita, E., Tatsumi, T., Kuzushita, N., Kasahara, A., Fusamoto, J., Yokochi, T., Kamada, T. (1997) B7/BB-I expression and hepatitis activity in liver tissues of patients with chronic hepatitis C. Hepatology 25, 713-718.
16. Porgador, A., Feldman, M., Eisenbach, L. (1994) Immunotherapy of tumor metastasis via gene therapy. Nat. Immun. 13, 113-130.
17. Rössner, P., Bubeník, J., Indrová, M., Sobota, V., Vondrys, P., Zeuthen, J., Jandlová, T. Takáč, M. (1997) Genetically modified tumour vaccines: insertion of the EL-2 gene down-regulates tumorigenicity more efficiently than insertion of the CD80 gene. Int. J. Oncol. 10, 77-82.
18. Saito, T., Tanaka, R., Yoshida, S., Washiyama, K., Kumanishi, T. (1988) Immunohistochemical analysis of tumor-infiltrating lymphocytes and major histocompatibility antigens in human gliomas and metastatic brain tumors. Surg. Neurol. 29, 435-442.
19. Seo, A., Ishikawa, F., Nakano, H., Nakazaki, H., Kobayashi, K., Kakiuchi, T. (1999) Enhancement of B7-1 (CD80) expression on B-lymphoma cells by irradiation. Immunology 96, 642-648.
20. Šínová, J., Bubeník, J., Jandlová, T., Indrová, M. (1998) Irradiated IL-2 gene-modified plasmacytoma vaccines are more efficient than live vaccines. Int. J. Oncol. 12, 1195-1198.
21. Townsend, A., Bodmer, H. (1989) Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol. 7, 601-624.