Acid-fast-positive Legionella pneumophila: A possible pitfall in the cytologic diagnosis of mycobacterial infection in pulmonary specimens

Diagnostic Cytopathology

Volumn 22, Issue 1, 2000, Pages 45-48

  Bentz, Joel S ^a   Carroll, Karen ^a   Ward, John H ^a   Elstad, Mark ^a,b   Marshall, C Jay ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acid fast stain; Bronchoalveolar lavage; Legionella; Mycobacteria; Pulmonary

Indexed keywords

ALPHA INTERFERON; ANTIINFECTIVE AGENT; CEFTAZIDIME; DEXAMETHASONE; FLUDARABINE; STREPTOMYCIN;

ACID FAST BACTERIUM; AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; CYTODIAGNOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; HUMAN; HUMAN TISSUE; LEGIONELLA PNEUMOPHILA; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MYCOBACTERIOSIS; PRIORITY JOURNAL;

BRONCHOALVEOLAR LAVAGE FLUID; CYTODIAGNOSIS; DIAGNOSIS, DIFFERENTIAL; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MALE; MIDDLE AGED; MYCOBACTERIUM INFECTIONS; PNEUMONIA, BACTERIAL; PROSTATIC NEOPLASMS; STAINING AND LABELING;

EID: 0033981295     PISSN: 87551039     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0339(200001)22:1<45::AID-DC12>3.0.CO;2-Y     Document Type: Article

References (21)

1. Huang L, Hecht FM, Stansell JD, Montani R, Hadley WK, Hopewell PC. Suspected Pneumocystis carinii pneumonia with negative induced sputum examination: is early bronchoscopy useful? Am J Respir Crit Care Med 1995;151:1866-1871.
2. Kovacs JA, Ng VL, Masur H. Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies. N Engl J Med 1988;318:589-593.
3. Broaddus C, Dake MD, Slulbard MS, Blumenfeld W, Hadley WK, Golden JA, Hopewell PC. Bronchoalveolar lavage and transbronchial biopsy for the diagnosis of pulmonary infections in the acquired immunodeficiency syndrome. Ann Intern Med 1985;102:747-752.
4. Golden JA, Hollander H, Stulbarg MS, Gamsu G. Bronchoalveolar lavage as the exclusive diagnostic modality for Pneumocystis carinii pneumonia. Chest 1986;90:18-22.
5. Baughman RP, Dohn MN, Frame PT. The continuing utility of bronchoalveolar lavage to diagnose opportunistic infection in AIDS patients. Am J Med 1994;97:515-522.
6. Goldstein RA, Rohatgi PK, Bergofsky EH, Daniele RP, Dantzker DR, Davis GS, Hunninghake GW, King TE Jr, Metzger WJ, et al. Clinical role of bronchoalveolar lavage in adults with pulmonary disease. Ann Rev Respir Dis 1990;142:481-486.
7. Myerowitz RL, Pasculle AW, Dowling JN, Pazin GR Sr, Puerzer M, Yee RB, Rinaldo CR Jr, Hakala TR. Opportunistic lung infection due to "Pittsburgh pneumonia agent." N Engl J Med 1979;391:953-958.
8. Hilton E, Freedman RA, Citron F, Isenberg HD, Singer C. Acid-fast bacilli in sputum: a case of Legionella micdadei pneumonia. J Clin Microbiol 1986;24:1102-1103.
9. Schwebke JR, Hackman R, Bowden R. Pneumonia due to Legionella micdadei in bone marrow transplant recipients. Rev Infect Dis 1990;12: 824-828.
10. Chapin K. Clinical microscopy. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, editors. Manual of clinical microbiology. Washington, DC: American Society for Microbiology; 1995. p 44-49.
11. Koneman EW, Legionella. In: Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Winn WC Jr, editors. Color atlas and textbook of diagnostic microbiology, 4th ed. Philadelphia: J.B. Lippincott Company; 1992. p 352-361.
12. Chandler FW, Hicklin MD, Blackman JA. Demonstration of the agent of Legionnaires' disease in tissue. N Engl J Med 1977;297:1218-1220.
13. Rogers BH, Donowitz GR, Walker GK, Harding SA, Sande MA. Opportunistic pneumonia: a clinicopathologic study of five cases caused by an unidentified acid-fast bacterium. N Engl J Med 1979;301: 959-961.
14. Talamo TS, Norbut AM, Kessler GF. Opportunistic pneumonia caused by a new acid-fast bacterium. Am J Clin Pathol 1980;74:842-845.
15. Winn WC, Myerowitz RL. The pathology of the Legionella pneumonias. Hum Pathol 1981;12:401-422.
16. Fang GD, Yu VL, Vickers RM. Infections caused by the Pittsburgh pneumonia agent. Semin Respir Infect 1987;2:262-266.
17. Walker AN, Walker GK, Feldman PS. Diagnosis of Legionella micdadei pneumonia from cytologic specimen. Acta Cytol 1983;27:252-254.
18. Hebert GA, Thomason BM, Harris PP, Hicklin MD, McKinney RM. "Pittsburgh pneumonia agent" - a bacterion phenotypically similar to Legionella pneumonphila and identical to TATLOCK bacteria. Ann Intern Med 1980;92:53-54.
19. Pasculle AW, Myerowitz R, Rinaldo C. New bacterial agent of pneumonia isolated from renal transplant recipients. Lancet 1979;2: 58-61.
20. Yu, VL, Zuravleff JJ, Elder EM, Brown A. Pittsburgh pneumonia agent may be a cause of nosocomia pneumonia: seroepidemiologic evidence. Ann Intern Med 1982;97:724-726.
21. Cluroe AD. Legionnaires' disease mimicking pulmonary miliary tuberculosis in the immunocompromised. Histopathology 1993;22: 73-75.