Hypercholesterolemia causes mechanical weakening of rabbit atheroma: Local collagen loss as a prerequisite of plaque rupture

Circulation Research

Volumn 86, Issue 1, 2000, Pages 101-108

  Rekhter, Mark D ^a   Hicks, Gary W ^a   Brammer, David W ^a   Hallak, Hussein ^a   Kindt, Erick ^a   Chen, Jing ^a   Rosebury, Wendy S ^a   Anderson, Maureen K ^a   Kuipers, Paul J ^a   Ryan, Michael J ^a  

^a PFIZER INC   (United States)

Author keywords

Arteriosclerosis; Cholesterol; Collagen; Macrophage; Plaque rupture

Indexed keywords

COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; CELL LOSS; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER;

EID: 0033977678     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.1.101     Document Type: Article

References (10)

1. Lee RT, Libby P. The unstable atheroma. Arterioscler Thromb Vasc Biol. 1997;17:1859-1867.
2. Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97:2110-2116.
3. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
4. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94: 2493-2503.
5. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 1998;97: 2433-2444.
6. Wight TN. The vascular extracellular matrix. In: Fuster V, Ross R, Topol EJ, eds. Atherosclerosis and Coronary Artery Disease. Philadelphia, Pa: Lippincott-Raven Publishers; 1996:421-440.
7. Rekhter MD, Hicks GW, Brammer DW, Work CW, Kim J-S, Gordon D, Keiser JA, Ryan MJ. Animal model that mimics atherosclerotic plaque rupture. Circ Res. 1998;83:705-713.
8. Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease. Circulation. 1990;82(suppl II):II-38-II-46.
9. van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimai rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89:36-44.
10. Kockx MM, De-Meyer GR, Buyssens N, Knaapen MW, Bull H, Herman AG. Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res. 1998;83: 378-387.