Regulation of the Na+2Cl-K+ cotransporter in isolated rat colon crypts

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 3, 2000, Pages 378-384

  Heitzmann, Dirk ^a   Warth, Richard ^a   Bleich, Markus ^a   Henger, Anna ^a   Nitschke, Roland ^a   Greger, Rainer ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

CAMP; Carbachol; Cl secretion; Exocrine secretion; K+ channels; Volume regulation

Indexed keywords

2,7 BIS(CARBOXYETHYL) 6 CARBOXYFLUORESCEIN; AMMONIA; AZOSEMIDE; BARIUM ION; CARBACHOL; CARRIER PROTEIN; CHLORIDE ION; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; LOOP DIURETIC AGENT; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM ION;

ACIDIFICATION; ALKALINIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL VOLUME; CRYPT CELL; EXOCRINE SECRETION; ION TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ALGORITHMS; ANIMALS; CARBACHOL; CARRIER PROTEINS; CELL SIZE; CHLORIDES; COLON; CYCLIC AMP; CYTOSOL; HYDROGEN-ION CONCENTRATION; HYPERTONIC SOLUTIONS; KINETICS; MUSCARINIC AGONISTS; POTASSIUM; QUATERNARY AMMONIUM COMPOUNDS; RATS; SODIUM; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; UP-REGULATION;

EID: 0033977613     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050953     Document Type: Article

References (27)

1. + conductance of freshly isolated TAL cells. Pflügers Arch 429:345-354
2. + and non-selective channels in the basolateral membrane of rat colonic crypt base cells. Pflügers Arch 432:1011-1022
3. 3. Bleich M, Warth R, Thiele I, Greger R (1998) pH-regulatory mechanisms in in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 436:248-254
4. 4. D'Andrea L, Lytle CY, Matthews JB, Hofman P, Forbush B, Madara JL (1996) Na:K:2Cl cotransporter (NKCC) of intestinal epithelial cells. J Biol Chem 271:28969-28976
5. - secretion but no cation inward conductance. Pflügers Arch 431:427-434
6. - cotransporter activity in rat parotid acinar cells by muscarinic stimulation. J Physiol (Lond) 499:351-359
7. 7. Greger R (1999) Cystic fibrosis. In: Lehmann-Horn F (ed) Channelopathies, 1st edn. (in press)
8. 8. Greger R (1999) Role of CFTR in the colon. Annu Rev Physiol (in press)
9. 9. Greger R, Bleich M, Leipziger J, Ecke D, Mall M, Kunzelmann K (1997) Regulation of ion transport in colonic crypts. News Physiol Sci 12:62-66
10. + cotransporter in the rectal gland of Squalus acanthias is activated by cell shrinkage. Pflügers Arch 438:165-176
11. 11. Greger R, Schlatter E, Gögelein H (1986) Sodium chloride secretion in rectal gland of dogfish Squalus acanthias. News Physiol Sci 1:134-136
12. 12. Greger R, Schlatter E, Wang F, Forrest JN (1984) Mechanism of NaCl secretion in rectal gland tubules of spiny dogfish (Squalus acanthias). III. Effects of stimulation of secretion by cyclic AMP. Pflügers Arch 402:376-384
13. 13. Heintze K, Stewart CP, Frizzell RA (1983) Sodium-dependent chloride secretion across rabbit descending colon. Am J Physiol 244:G357-G365
14. 14. Hoffmann EK, Dunham PB (1995) Membrane mechanisms and intracellular signaling in cell volume regulation. Int Rev Cytol 161:173-262
15. 2+ calmodulin and protein kinase C dependent pathways. J Membr Biol 131:161-178
16. 3. Nature 339:478-480
17. 29 colon carcinoma cells. Pflügers Arch 428:179-185
18. - cotransport in Ehrlich cells: regulation by protein phosphatases and kinases. Am J Physiol 275:C239-C250
19. 19. Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, Häussinger D (1998) Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247-306
20. 20. Lytle C, Forbush B (1996) Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl. Am J Physiol 270:C437-C448
21. 29 cells. Pflügers Arch 434:466-474
22. 22. Payne JA, Xu JC, Haas M, Lytle CY, Ward D, Forbush B (1995) Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon. J Biol Chem 270:17977-17985
23. + uptake in colonic crypts. Pflügers Arch 438:508-515
24. i. Am J Physiol 267:C146-C156
25. + cotransporter in in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 436:521-528
26. + channel (rSK4) of colonic crypts. Pflügers Arch 438:437-444
27. + conductance of rat colonic crypt base cells. Pflügers Arch 432:81-88