A peripheral site of action for the attenuation of baroreflex-mediated bradycardia by intravenous μ-opioid agonists

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 2, 2000, Pages 269-274

  Omoniyi, Abimbola T ^a   Kelt, Attila ^b   Wu, Dunli ^a   Soong, Yi ^a   Clapp III, James F ^b   Szeto, Hazel H ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Baroreflex; Cardiovascular; DALDA; DAMGO; Heart rate

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; NITROPRUSSIDE SODIUM; NORADRENALIN; TYROSYL DEXTRO ARGINYLPHENYLALANYLLYSINAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE REGULATION; BRADYCARDIA; DRUG EFFECT; DRUG RECEPTOR BINDING; HEART RATE VARIABILITY; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SHEEP; VAGUS REFLEX;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BAROREFLEX; BRADYCARDIA; CATHETERS, INDWELLING; DRUG INTERACTIONS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FEMALE; NALOXONE; NARCOTIC ANTAGONISTS; NITROPRUSSIDE; NOREPINEPHRINE; OLIGOPEPTIDES; PREGNANCY; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, OPIOID, MU; SHEEP;

EID: 0033977532     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200002000-00014     Document Type: Article

References (8)

1. Gordon FJ. Opioids and the nucleus of the tractus solitarius: effects on cardiovascular and baroreflex function. In: Robin AI, ed. Nucleus of the solitary tract. Boca Raton, FL: CRC press, 1994:283-7.
2. Numao Y, Siato M, Terui N, Kumada M. The aortic nerve-sympathetic reflex in the rat. J Anton Nerv Syst 1985;13:65-79.
3. Petty MA, Reid JL. The effect of opiates on arterial baroreceptor reflex function in the rabbit. Naunyn Schmiedebergs Arch Pharmacol 1982;319:206-11.
4. Schaz K, Stock G, Simon W, et al. Enkephalin effects on blood pressure, heart rate, and baroreceptor reflex. Hypertension 1980; 2:395-107.
5. Yukimura T, Stock G, Stumpf H, Unger T, Ganden D. Effects of [D-Ala2]-methionine-enkephalin on blood pressure, heart rate, and baroreceptor reflex sensitivity in conscious rats. Hypertension 1981;3:528-33.
6. Clapp JF, Kelt A, Olariu N, et al. Cardiovascular and metabolic responses to two receptor-selective opioid agonists in pregnant sheep. Am J Obstet Gynecol 1998;178:397-401.
7. Omoniyi AT, Wu DL, Soong Y, Szeto HH. Baroreflex-mediated bradycardia is blunted by intravenous μ- but not κ-opioid agonists. J Cardiovasc Pharmacol 1998;31:954-9.
8. Kelt A, Omoniyi AT, Kim H, et al. Baroreflex-mediated brady-cardia is blunted by intravenous μ-opioid agonists in chronically-instrumented pregnant sheep. Am J Obstet Gynecol 1998;178: 950-5.