Expression of interleukin-6 in human dorsal root ganglion cells

Neuroscience Letters

Volumn 280, Issue 2, 2000, Pages 139-142

  Nordlind, K ^a   Eriksson, L ^a   Seiger, A ^b   Bakhiet, M ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dorsal root ganglia; IL 6; Immunohistochemistry; In situ hybridization; mRNA

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; INTERLEUKIN 6; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SPINAL CORD; SPINAL GANGLION; WHITE MATTER;

CALCITONIN GENE-RELATED PEPTIDE; CHILD; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERLEUKIN-6; MALE; RNA, MESSENGER; SUBSTANCE P;

EID: 0033975713     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00772-2     Document Type: Article

References (20)

1. Brakenhoff, J.P., de Hon, F.D., Fontaine, V., ten Boekel, E., Schooltink, H., Rose-John, S., Heinrich, P.C., Content, J. and Aarden, L.A., Development of a human interleukin-6 receptor antagonist. J. Biol. Chem., 269 (1994) 86-93.
2. Dagerlind, Å., Friberg, K., Bean, A.J. and Hökfelt, T., Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry, 98 (1992) 39-49.
3. Fann, M.-J. and Patterson, P.H., Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons. Proc. Natl. Acad. Sci. USA, 91 (1994) 43-47.
4. Gadient, R.A. and Otten, U.H., Identification of interleukin-6 (IL-6)- expressing neurons in the cerebellum and hippocampus of normal adult rats. Neurosci. Lett., 182 (1994) 243-246.
5. Gadient, R.A. and Otten, U.H., Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia. Brain. Res., 724 (1996) 41-46.
6. Gadient, R.A. and Otten, U.H., Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials. Prog. Neurobiol., 52 (1997) 379-390.
7. Gijbels, K., Van Damme, J., Proost, P., Put, W., Carton, H. and Billiau, A., Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol., 20 (1990) 233-235.
8. Gruol, D.L. and Nelson, T.E., Physiological and pathological roles of interleukin-6 in the central nervous system. Mol. Neurobiol., 15 (1997) 307-339.
9. Hirohata, S. and Miyamoto, T., Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthritis Rheum, 33 (1990) 644-649.
10. Kiefer, R., Lindholm, D. and Kreutzberg, G.W., Interleukin-6 and transforming growth factor-beta 1 mRNAs are induced in rat facial nucleus following motoneuron axotomy. Eur. J. Neurosci., 5 (1993) 775-781.
11. Kishimoto, T., The biology of interleukin-6. Blood, 74 (1989) 1-10.
12. Lemke, R., Härtig, W., Rossner, S., Bigl, V. and Schliebs, R., Interleukin-6 is not expressed in activated microglia and in reactive astrocytes in response to lesion of rat basal forebrain cholinergic system as demonstrated by combined in situ hybridization and immunocytochemistry. J. Neurosci. Res., 51 (1998) 223-236.
13. März, P., Cheng, J.-G., Gadient, R.A., Patterson, P.H., Stoyan, T., Otten, U. and Rose-John, S., Sympathetic neurons can produce and respond to interleukin 6. Proc. Natl. Acad. Sci. USA, 95 (1998) 3251-3256.
14. Nordlind, K., Chen, L., Ahmed, A.A., Brakenhoff, J., Theodorsson, E. and Lidén, S., Immunohistochemical localization of interleukin-6-like immunoreactivity to peripheral nerve-like structures in normal and inflamed human skin. Arch. Derm. Res., 288 (1996) 431-435.
15. Ringheim, G.E., Burgher, K.L. and Heroux, J.A., Interleukin-6 mRNA expression by cortical neurons inculture: evidence for neuronal sources of interleukin-6 production in the brain. J. Neuroimmunol., 63 (1995) 113-123.
16. Schiefer, J., Topper, R., Schmidt, W., Block, F., Heinrich, P.C., Noth, J. and Schwarz, M., Expression of interleukin 6 in the rat striatum following stereotaxic injection of quinolinic acid. J. Neuroimmunol., 89 (1998) 168-176.
17. Schöbitz, B., Voorhuis, D.A.M. and De Kloet, E.R., Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Neurosci. Lett., 136 (1992) 189-192.
18. Ye, J. and Young, H.A., Negative regulation of cytokine gene transcription. FASEB J., 11 (1997) 825-833.
19. Zhong, J., Dietzel, I.D., Wahle, P., Kopf, M. and Heumann, R., Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice. J. Neurosci., 19 (1999) 4305-4313.
20. Zhong, J. and Heumann, R., Lesion-induced interleukin-6 mRNA expression in rat sciatic nerve. Ann. N.Y. Acad. Sci., 762 (1995) 488-490.