No objective benefit from steroids inhaled via a spacer in infants recovering from bronchiolitis

European Respiratory Journal

Volumn 15, Issue 2, 2000, Pages 388-394

  Wong, J Y W ^a   Moon, S ^a   Beardsmore, C ^a   O'Callaghan, C ^a   Simpson, H ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Bronchiolitis; Cough; Inhaled steroids; Lung function; Oxygen saturation; Spacer devices

Indexed keywords

FLUTICASONE PROPIONATE; STEROID;

ARTICLE; BRONCHIOLITIS; CLINICAL ARTICLE; COUGHING; FEMALE; HUMAN; INFANT; INHALER; LUNG FUNCTION TEST; MALE; NEWBORN; OXYGEN SATURATION; PRIORITY JOURNAL; STEROID THERAPY; SYMPTOMATOLOGY;

ADMINISTRATION, INHALATION; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BRONCHIOLITIS, VIRAL; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INFANT, NEWBORN; MALE; NEBULIZERS AND VAPORIZERS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; TIME FACTORS;

EID: 0033974949     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3003.2000.15b27.x     Document Type: Article

References (44)

1. Henry RL, Hodges IGC, Milner AD, Stokes GM. Respiratory problems 2 years after acute bronchiolitis in infancy. Arch Dis Child 1983; 58: 713-716.
2. Webb MSC, Henry RL, Alexander J, Milner AD, Stokes GM, Swarbrick AS. Continuing respiratory problem three and a half years after acute viral bronchiolitis. Arch Dis Child 1985; 60: 1064-1067.
3. Murray M, Webb MSC, O'Callaghan C, Swarbrick AS, Milner AD. Respiratory status and allergy after bronchiolitis. Arch Dis Child 1992; 67: 482-487.
4. Sly PD, Hibbert ME. Childhood asthma following hospitalization with acute viral bronchiolitis in infancy. Pediatr Pulmonol 1989; 7: 153-158.
5. Eisen AH, Baca HI. The relationship of acute bronchiolitis to bronchial asthma: a 4-to-14 year follow-up. Pediatrics 1963; 31: 859-861.
6. Wittig HJ, Cranford NJ, Glaser J, Rochester NY. The relationship between bronchiolitis and childhood asthma: a follow-up study of 100 cases of bronchiolitis in infancy. J Allergy 1959; 30: 19-23.
7. Mok JYQ, Simpson H. Outcome for acute bronchitis, bronchiolitis, and pneumonia in infancy. Arch Dis Child 1984; 59: 306-309.
8. Sims DG, Downham MAPS, Gardner PS, Webb JKG, Weightman D. Study of 8-year-old children with a history of respiratory synctial virus bronchiolitis in infancy. BMJ 1978; 1: 11-14.
9. McConnochie KM, Roghmann KJ. Wheezing at 8 and 13 years: changing importance of bronchiolitis and passive smoking. Pediatr Pulmonol 1989; 6: 138-146.
10. Noble V, Murray M, Webb MSC, Alexander J, Swarbrick AS, Milner AD. Respiratory status and allergy nine to 10 years after acute bronchiolitis. Arch Dis Child 1997; 76: 315-319.
11. Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. BMJ 1982; 284: 1665-1669.
12. Kattan M, Keens TG, Lapierrre J, Levison H, Bryan AC, Reilly BJ. Pulmonary function abnormalities in symptomfree children after bronchiolitis. Pediatrics 1977; 59: 683-688.
13. Rosenberg D, Tsangaris M, Eigen H, Tepper R. Outpatient bronchiolitis longitudinal evaluation. Am Rev Respir Dis 1989; 139 (Suppl. 2): A317.
14. Wohl MEB, Stigol LC, Mead J. Resistance of the total respiratory system in healthy infants and infants with bronchiolitis. Pediatrics 1969; 43: 495-509.
15. Mallory GBJ, Motoyama EK, Koumbourlis AC, Mutich RL, Nakayama DK. Bronchial reactivity in infants in acute respiratory failure with viral bronchiolitis. Pediatr Pulmonol 1989; 6: 253-259.
16. Seidenberg J, Masters IB, Hudson I, Olinsky A, Phelan PD. Disturbance in respiratory mechanics in infants with bronchiolitis. Thorax 1989; 44: 660-667.
17. Stokes GM, Milner AD, Hodges IGC, Groggins RC. Lung function abnormalities after acute bronchiolitis. J Pediatr 1981; 98: 871-874.
18. Henry RL, Milner AD, Stokes GM, Hodges IGC, Groggins RC. Lung function after acute bronchiolitis. Arch Dis Child 1983; 58: 60-63.
19. Dezateux C, Fletcher ME, Dundas I, Stock J. Infant respiratory function after RSV-proven bronchiolitis. Am J Respir Crit Care Med 1997; 155: 1349-1355.
20. McConnochie KM, Mark JD, McBride JT, et al. Normal pulmonary function measurements and airway reactivity in childhood after mild bronchiolitis. J Pediatr 1985; 107: 54-58.
21. Young S, O'Keeffe PT, Arnott J, Landau LI. Lung function, airways responsiveness, and respiratory symptoms before and after bronchiolitis. Arch Dis Child 1995; 72: 16-24.
22. Tepper RS, Rosenberg D, Eigen H. Airway responsiveness in infants following bronchiolitis. Pediatr Pulmonol 1992; 13: 6-10.
23. Caswell SJ, Thompson AH, Ashmore SP, Beardsmore CS, Simpson H. Latent sensitisation to respiratory syncytial virus during acute bronchiolitis and lung function after recovery. Arch Dis Child 1990; 65: 946-952.
24. Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet 1996; 348: 292-295.
25. Dennis JL. Steroid in the treatment of obstructive bronchiolitis: a double-blind study. South Med J 1963; 56: 1436.
26. Sussman S, Grossman M, Magoffin R, Schieble J. Dexamethasone (16 α-methy, 9 α-fluoroprenisolone) in obstructive respiratory tract infections in children: a controlled study. Pediatrics 1964; 34: 851-855.
27. Dabbous IA, Tkachyk JS, Stamm SJ. A double-blind study on the effects of corticosteroids in the treatment of bronchiolitis. Pediatrics 1966; 7: 477-484.
28. Leer JA, Green JL, Heimlich EM, et al. Corticosteroid treatment in bronchiolitis: a controlled, collaborative study in 297 infants and children. Am J Dis Child 1969; 117: 495-503.
29. Lin Y-Z, Hsieh K-H, Chen W, Wu K-W. Clinical trial of corticosteroid and beta-2 bronchodilator in acute wheezing infants. Acta Paediatr Sin 1991; 32: 333-340.
30. Springer C, Bar-Yishay E, Uwayyed K, Avital A, Vilozni D, Godfrey S. Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis. Pediatr Pulmonol 1990; 9: 181-185.
31. Maayan C, Itzhaki T, Bar-Yishay E, Gross S, Tal A, Godfrey S. The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate. Pediatr Pulmonol 1986; 2: 9-14.
32. Carlsen K, Leegaard J, Larsen S, Ørstavik I. Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis. Arch Dis Child 1988; 63: 1428-1433.
33. Reijonen T, Korppi M, Kuikka L, Kyllikki R. Anti-inflammatory therapy reduces wheezing after bronchiolitis. Arch Pediatr Adolesc Med 1996; 150: 512-517.
34. Richter H, Seddon P. Early nebulized budesonide in the treatment of bronchiolitis and the prevention of post-bronchiolitic wheezing. J Pediatr 1998; 132: 849-853.
35. Fox GF, Everard ML, Marsh MJ, Milner AD. Randomised controlled trial of budesonide for the prevention of post-bronchiolitis wheezing. Arch Dis Child 1999; 80: 343-347.
36. Court SDM. The definition of acute respiratory illness in children. Postgrad Med J 1973; 49: 771-776.
37. Archer LNJ, Simpson H. Night cough counts and diary card scores in asthma. Arch Dis Child 1985; 60: 473-474.
38. Stocks J, Marchai F, Kraemer R, Gutkowski P, Bar-Yishay, E, Godfrey S. Plethysmographic assessment of functional residual capacity and airway resistance. In: Stocks J, Sly PD, Tepper RS, Morgan W, eds. Infant Respiratory Function Testing. New York, Wiley, 1996.
39. Taussig LM, Landau LI, Godfrey S, Arad I. Determinants of forced expiratory flows in newborn infants. J Appl Physiol 1982; 53: 1220-1227.
40. Cockcroft DW, Berscheid BA. Standardization of bronchial inhalational provocation test: dose versus concentration of histamine. Chest 1982; 82: 572-575.
41. Martin Bland. Multiple Significant Tests. An Introduction to Medical Statistics. 2nd Edn. Oxford, Oxford University Press, 1995; pp. 146-147.
42. Hampton F, Beardsmore CS, Morgan W, Williams A, Taussig L. A scoring system for lung function tests in infants. Pediatr Pulmonol 1992; 14: 149-155.
43. Wong J, Davies T, O'Callaghan C. Delivery of fluticasone propionate (FP) to infants following bronchiolitis. Dose determination from Babyhaler and effect on urinary cortisol. Eur Respir J 1997; 10 (Suppl. 25); 83s.
44. Noble V, Ruggins NR, Everard ML, Milner AD. Inhaled budesonide for chronic wheezing under 18 months of age. Arch Dis Child 1992; 67: 285-288.