Lumen-to-surface pH gradients in opossum and rabbit esophagi: Role of submucosal glands

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 1 41-1, 2000, Pages

  Abdulnour Nakhoul, Solange ^a   Nakhoul, Nazih L ^a   Orlando, Roy C ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acid reflux; Alkaline secretion; Carbachol; Microelectrodes

Indexed keywords

ATROPINE; BICARBONATE; CARBACHOL;

ACIDITY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ESOPHAGUS MUCOSA; ESOPHAGUS PH; HISTOLOGY; INTESTINE EPITHELIUM; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; RABBIT; SUBMUCOSA; SURFACE PROPERTY;

EID: 0033974847     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.1.g113     Document Type: Article

References (20)

1. Allen, A., and A. Garner. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Gut 21: 249-262, 1980.
2. Al Yassin, T. M., and P. G. Toner. Fine structure of squamous epithelium and submucosal glands of human oesophagus. J. Anat. 123: 705-721, 1977.
3. Ammann, D., F. Lanter, R. A. Steiner, P. Schulthess, Y. Shijo, and W. Simon. Neutral carrier based hydrogen ion-selective microelectrode for extra- and intracellular studies. Anal. Chem. 53: 2267-2269, 1981.
4. Barclay, R. L., M. J. Feldman, W. G. Paterson, and G. P. Morris. Regional heterogeneity in glycoconjugate expression in opossum esophagus (Abstract). Gastroenterology 110: A56, 1996.
5. Boyd, D. D., C. N. Carney, and D. W. Powell. Neurohumoral control of esophageal epithelial electrolyte transport. Am. J. Physiol. Gastrointest. Liver Physiol. 239: G5-G11, 1980.
6. Engel, E., P. H. Guth, Y. Nishizaki, and J. D. Kaunitz. Barrier function of the gastric mucus gel. Am. J. Physiol. Gastrointest. Liver Physiol. 269: G994-G999, 1995.
7. Flemstrom, G., and E. Kivilaakso. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 84: 787-794, 1983.
8. Goetsch, E. The structure of the mammalian oesophagus. Am. J. Anat. 10: 1-39, 1910.
9. Hamilton, B. H., and R. C. Orlando. In vivo alkaline secretion by mammalian esophagus. Gastroenterology 97: 640-648, 1989.
10. Hamilton, B. H., N. A. Tobey, M. C. Starnes, V. J. Schreiner, and R. C. Orlando. Effect of adrenergic and cholinergic agents on esophageal bicarbonate secretion in opossums. Am. J. Physiol. Gastrointest. Liver Physiol. 267: G67-G70,1994.
11. Hopwood, D., G. Coghill, and D. S. Sanders. Human oesophageal submucosal glands. Their detection of mucin, enzyme and secretory protein content. Histochemistry 86: 107-112, 1986.
12. 3 layer protects against intracellular acidosis in acid-exposed gastric mucosa. Am. J. Physiol. Gastrointest. Liver Physiol. 264: G57-G63, 1993.
13. Krause, W. J., J. H. Cutts, and C. R. Leeson. The postnatal development of the alimentary canal in the opossum. I. Oesophagus. J. Anat. 122: 293-314, 1976.
14. Marklin, G. F., W. J. Krause, and J. H. Cutts. Structure of the esophagus in the adult opossum, Didelphis virginiana. Anat. Anz. 145: 249-261, 1979.
15. Meyers, R. L., and R. C. Orlando. In vivo bicarbonate secretion by human esophagus. Gastroenterology 103: 1174-1178, 1992.
16. Namiot, Z., J. Sarosiek, R. M. Rourk, D. P. Hetzel, and R. W. McCallum. Human esophageal secretion: mucosal response to luminal acid and pepsin. Gastroenterology 106: 973-981, 1994.
17. Quigley, E. M., and L. A. Turnberg. pH of the microclimate lining human gastric and duodenal mucosa in vivo. Studies in control subjects and in duodenal ulcer patients. Gastroenterology 92: 1876-1884, 1987.
18. Takeuchi, K., D. Magee, J. Critchlow, J. Matthews, and W. Silen. Studies of the pH gradient and thickness of frog gastric mucus gel. Gastroenterology 84: 331-340, 1983.
19. Tobey, N. A., C. Caymaz-Bor, S. S. Hosseine, M. S. Awayda, and R. C. Orlando. Circuit analysis of cell membrane and junctional resistances in healthy and acid-damaged rabbit esophageal epithelium. Gastroenterology 116: A334-A335, 1999.
20. Williams, S. E., and L. A. Turnberg. Retardation of acid diffusion by pig gastric mucosa: a potential role in mucosal protection. Gastroenterology 79: 299-304, 1980.