Psychiatric genetics: Back to the future

Molecular Psychiatry

Volumn 5, Issue 1, 2000, Pages 22-31

  Owen, M J ^a   Cardno, A G ^a   O'Donovan, M C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Epidemiology; Genomics; Linkage; Linkage disequilibrium; Molecular; Phenotype

Indexed keywords

ALCOHOLISM; ANXIETY NEUROSIS; BEHAVIOR; DEPRESSION; GENOME; HUMAN; MANIC DEPRESSIVE PSYCHOSIS; MOLECULAR GENETICS; PANIC; PHOBIA; PRIORITY JOURNAL; PSYCHIATRY; REVIEW; SCHIZOPHRENIA;

EID: 0033974662     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000702     Document Type: Review

References (84)

1. 1 Neale MC, Cardon LR. Methodology for Genetic Studies of Twins and Families. NATO ASI Series: Kluwer Academic Publishers: Dordrecht, 1992.
2. 2 McGuffin P, Owen MJ. O'Donovan MC, Thapar A, Gottesman I. Seminars in Psychiatric Genetics. Gaskell: London 1994.
3. 3 Kendler KS, Neale MC, Kassler RC, Heath AC, Eaves LJ. Major depression and generalized anxiety disorder: same genes, (partly) different environments? Arch Gen Psychiatry 1992; 49: 716-722.
4. 4 Kendler KS, Tsuang MT, Hays P. Age at onset in schizophrenia: a familial perspective. Arch Gen Psychiatry 1987; 44: 881-890.
5. 5 Neale MC, Eaves LJ, Hewitt JK, MacLean CJ, Meyer JM, Kendler KS. Analysing the relationship between age at onset and risk to relatives. Am J Hum Genet 1989; 45: 226-239.
6. 6 Kendler KS, Karkowski-Shuman L, O'Neill FA, Straub RE, MacLean CJ, Walsh D. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish study of high-density schizophrenia families: evidence for possible etiologic heterogeneity. Am J Psychiatry 1997; 154: 191-198.
7. 7 Kendler KS, Neale M, Kessler R et al. A twin study of recent life events and difficulties. Arch Gen Psychiatry 1993; 50: 789-796.
8. 8 Thapar A, McGuffin P. Genetic influences on life events in childhood. Psychol Med 1996; 26: 813-820.
9. 9 McGuffin P, Katz R, Bebbington P. The Camberwell Collaborative Depression Study III. Depression and adversity in the relatives of depressed probands. Br J Psychiatry 1988; 152: 775-782.
10. 10 Owen MJ, McGuffin P. Genetics and psychiatry. Br J Psychiatry 1997; 171: 201-202.
11. 11 Precott CA, Kendler KS. Age at first drink and risk for alcoholism: a noncausal association. Alc Clin Exp Res 1999; 23: 101-107.
12. 12 Tienari P, Lyman CW, Moring J, Lahti I, Naarala M, Sorri A et al. The Finnish adoptive family study of schizophrenia: implications for family research. Br J Psychiatry 1994; 164 (suppl 23): 20-26.
13. 13 Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart E. Gene-environment interaction in the genesis of aggressivity and conduct disorder. Arch Gen Psychiatry 1995; 52: 916-924.
14. 14 Lendon C, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997; 277: 825-831.
15. 15 Hardy J, Gwinn-Hardy K. Genetic classification of primary neurodegenerative disease. Science 1998; 282: 1075-1079.
16. 16 Hardy J, Israël A. Alzheimer's disease: in search of γ-secretase. Nature 1999; 398: 466-467.
17. 17 McGuffin P, Owen MJ. Molecular genetic studies of schizophrenia. Cold Spring Harb Symp Quant Biol 1996; 61: 815-822.
18. 18 Suarez BK, Hampe CL, Van Eerdewegh P. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR (eds). Genetic Approaches to Mental Disorders. American Psychiatric Press: Washington, DC, 1994, pp 23-46.
19. 19 Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
20. 20 Owen MJ, Holmans P, McGuffin P. Association studies in psychiatric genetics. Mol Psychiatry 1997; 2: 270-273.
21. 21 Risch N, Teng J. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases: I. DNA pooling. Genome Res 1998; 8: 1273-1288.
22. 22 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al. Gene dose of apolipoprotein E type-4 allele and the risk of Alzheimer's disease in late-onset families. Scíence 1993; 261: 921-923.
23. 23 National Institute on Aging/Alzheimer's Association Working Group. Apolipoprotein E genotyping in Alzheimer's disease. Lancet 1996; 347: 1091-1095.
24. 24 Williams J, Spurlock G, McGuffin P et al. Association between schizophrenia and the T102C polymorphism of 5-hydroxytryptamine type 2a receptor gene. Lancet 1996; 347: 1294-1296.
25. 25 Williams J, McGuffin P, Nothen M, Owen MJ and the EMASS Collaborative Group. Meta-analysis of association between the 5HT2a receptor T102C polymorphism and schizophrenia. Lancet 1997; 349: 1221.
26. 26 Houwen RHJ, Baharloo S, Blankenship K et al. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nature Genet 1994; 8: 380-386.
27. 27 Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genet 1999; 22: 139-144.
28. 28 Owen MJ. Will schizophrenia become a graveyard for molecular geneticists? Psychol Med 1992; 22: 289-293.
29. 29 Collins FS, Guyer MS, Chakravarti A. Variation on a theme: cataloging human DNA sequence variation. Science 1997; 278: 1580-1581.
30. 30 Wang DG, Fan JB, Siao CJ et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 1998; 280: 1077-1082.
31. 31 Jorde LB, Watkins WS, Carlson M, Groden J, Albertson H, Thliveris A et al. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet 1994; 54: 884-898.
32. 32 Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genet 1999 22: 231-238.
33. 33 Kendler KS, MacLean CJ, Ma YL, O'Neill FA, Walsh D, Straub RE. Market-to-marker linkage disequilibrium on chromosomes 5q, 6p and 8p in the Irish high-density schizophrenia pedigrees. Am J Med Genet 1999; 88: 29-33.
34. 34 Petruhkin K, Fischer SG, Pirastu M, Tanzi RF, Chrnov I, Devoto M et al. Mapping cloning and genetic characterization of the region containing in Wilson disease gene. Nature Genet 1993; 5: 338.
35. 35 Peterson AC, Di Rienzo A, Lehesjoki A-E, de la Chapelle A, Slatkin M, Freimer NB. The distribution of linkage disequilibrium over anonymous genome regions. Hum Mol Genet 1995: 4: 887-894.
36. 36 Lander ES. Array of hope. Nature Genet 1999; 21 (suppl): 3-4.
37. 37 Barcellos LF, Klitz W, Field L, Tobias R, Bowcock AM, Wilson R et al. Association of mapping of disease loci by use of a pooled DNA genomic screen. Am J Hum Genet 1997; 61: 734-747.
38. 38 Biomed European Bipolar Collaborative Group. No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Br J Psychiatry 1997; 170: 526-528.
39. 39 Barden N, Morissette J, Shink E, Rochette D, Gagne B, Bordeleau L et al. Confirmation of bipolar affective disorder susceptibility locus on chromosome 12 in the region of the Darier disease gene. Am J Med Genet 1998; 81: 475.
40. 40 Kirov G, Murphy KC, Arranz MJ, Jones I, McCandless F, Kunugi H et al. Low activity allele of catecho-o-methyl transferase gene associated with rapid cycling bipolar affective disorder. Mol Psychiatry 1998; 3: 342-345.
41. 41 Fisher PJ, Turic D, Williams NM, McGuffin P, Asherson P, Ball D et al. DNA pooling identifies QTLs for general cognitive ability in children on chromosome 4. Hum Mol Genet 1999; 8: 915-922.
42. 42 Hoogendoorn B, Owen MJ, Oefner PJ, Williams N, Austin J, O'Donovan MC. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Hum Genet 1999; 104: 89-93.
43. 43 DeLisi LE. A critical overview of recent investigations into the genetics of schizophrenia. Curr Opin Psychiatry 1999; 12: 29-39.
44. 44 Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 1995; 57: 439-454.
45. 45 Cardon LR, Smith SD, Fulker DW, Kimberling WJ, Pennington BF, DeFries JC. Quantitative trait locus for reading disability on chromosome 6. Science 1994; 266: 276-279.
46. 46 Page GP, Amos CI. Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. Am J Hum Genet 1999; 64: 1194-1205.
47. 47 Waldman ID, Rowe DC, Abramowitz A et al. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 1998; 63: 1767-1776.
48. 48 Flint J. Freeze! Nat Genet 1997; 17: 250-251.
49. 49 Flint J, Corley R, DeFries JC et al. A simple genetic-basis for a complex psychological trait in laboratory mice. Science 1995; 269: 1432-1435.
50. 50 Murphy KC, Jones LA, Owen MJ. Elevated rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999; 56: 940-945.
51. 51 Lindsay EA, Botta A, Jureuc V et al. Congenital heart disease in mice deficient for the DiGeorge Syndrome region. Nature 1999; 40: 379-383.
52. 52 Sham PC. Statistical methods in psychiatric genetics. Stat Meth Med Res 1998; 7: 279-300.
53. 53 Nuffield Council on Bioethics. Mental Disorders and Genetics: the Ethical Context. Nuffield Council on Bioethics: London, 1998.
54. 54 Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ et al. Heritability estimates for psychotic disorders. Arch Gen Psychiatry 1999; 56: 162-168.
55. 55 Kendler KS, Pedersen NL, Neale MC, Mathé AA. A pilot Swedish twin study of affective illness including hospital-and population-ascertained subsamples: results of model fitting. Behav Genet 1995; 3: 217-232.
56. 56 Kondler KS, Walters EE, Neale MC, Kessler RC, Heath AC, Eaves LJ. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women: phobia, generalized anxiety disorder, panic disorder, bulimia, major depression and alcoholism. Arch Gen Psychiatry 1995; 52: 374-383.
57. 57 Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS. Support for a possible schizophrenia vulnerability locus in a region of 5q22-31 in Irish families. Mol Psychiatry 1997; 2: 148-155.
58. 58 Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nature Genet 1998; 20: 70-73.
59. 59 Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6, and 8. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicentre study. Am J Med Genet 1996; 67: 580-594.
60. 60 Wildenauer DB, Schwab SG, Hallmayer J, Lerer B, Albus M, Borrman M et al. Genome scan for autosomal genes conferring risk to schizophrenia in a German/Israeli sample. Am J Med Genet 1998; 81: 454.
61. 61 Schizophrenia Collaborative Linkage Group. A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Am J Med Genet 1996; 67: 40-45.
62. 62 Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL et al. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genet 1996; 12: 431-435.
63. 63 Blackwood DHR, He L, Morris SW, McLean A, Whitton C, Thomson M et al. A locus for bipolar affective disorder on chromosome 4p. Nature Genet 1996; 12: 427-430.
64. 64 Ewald H, Mors O, Flint T, Koed K, Eiberg H, Kruse TA. A possible locus for manic depressive illness on chromosome 16p13. Psychiatr Genet 1995; 5: 71-81.
65. 65 Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C et al. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 1995; 57: 1384.
66. 66 Berrettini WH, Ferraro TN, Goldin LR et al. Pericentromeric chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci 1994; 91: 5918-5921.
67. 67 Straub RE, Lehner T, Luo Y, Loth JE, Shao W, Sharpe I et al. A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genet 1994; 8: 291-296.
68. 68 Kelsoe JR, Loetscher E, Spence MA, Foguet M, Sadovnick AD, Remick RA et al. A genome survey of bipolar disorder indicates a susceptibility locus on chromosome 22. Am J Med Genet 1998; 81: 461-462.
69. 69 Pekkarinen P, Bredbacka PE, Terwilliger J et al. Evidence for a susceptibility locus for manic depressive disorder in Xq26. Am J Hum Genet 1994; 55: 133.
70. 70 Philippe A, Martinez M, GuilloudBataille M, Gillberg C, Rastam M, Sponheim E et al. Genome-wide scan for autism susceptibility genes. Hum Mol Genet 1999; 8: 805-812.
71. 71 International Molecular Genetic Study of Autism Consortium. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 1998; 7: 571-578.
72. 72 Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, VanEerdewegh P et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 1998; 81: 207-215.
73. 73 Kehoe PG, Wavrant De Vrieze F, Crook R, Wu WS, Holman P, Fenton I et al. A full genome scan for late onset Alzheimer's disease. Hum Mol Genet 1999; 8: 237-245.
74. 74 Pericak-Vance MA, Bass ML, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA et al. Complete genomic screen in late-onset familial Alzheimer's disease. Neurobiol Aging 1998; 19: S39-S42.
75. 75 Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 1995; 11: 241-247.
76. 76 Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RCP et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genet 1998; 19: 357-360.
77. 77 Kehoe PG, Carsten R, Mcllroy S, Williams H, Holmans P, Holmes C et al. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer's disease. Nature Genet 1999; 21: 71-72.
78. 78 Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L et al. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 1998; 3: 141-149.
79. 79 Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P et al. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 1996; 7: 1675-1679.
80. 80 Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733.
81. 81 Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
82. 82 Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE et al. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 1995; 56: 993-998.
83. 83 LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N et al. Dopamine D4 receptor gene polymorphism is associated with attention-deficit hyperactivity disorder. Mol Psychiatry 1996; 1: 121-124.
84. 84 Rieder MJ, Taylor SL, Clark AG, Nickerson DA. Sequence variation in human Angiotensin Converting Enzyme. Nature Genet 1999; 22: 59-62.