Evidence for immunotoxic effects of crude Ginkgo biloba L. leaf extracts using the popliteal lymph node assay in the mouse

International Journal of Immunopharmacology

Volumn 22, Issue 3, 2000, Pages 229-236

  Koch, E ^a   Jaggy, H ^a   Chatterjee, S S ^a  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

Alkylphenols; Contact dermatitis; Ginkgo biloba extract EGb 761; Ginkgolic acids; Popliteal lymph node assay

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG HYPERSENSITIVITY; GINKGO BILOBA; HUMAN; HUMAN CELL; IMMUNOTOXICITY; LYMPH NODE; MALE; MOUSE; NONHUMAN; POPLITEAL LYMPH NODE; PRIORITY JOURNAL; PROVOCATION TEST;

ANIMALS; DERMATITIS, CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GINKGO BILOBA; LYMPH NODES; MALE; MICE; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 0033974421     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(99)00080-6     Document Type: Article

References (28)

1. Kawamura J. Über die chemischen Bestandteile der Frucht von Ginkgo biloba (I. Mitteilung). Jap. J. Chem. 3:1928;89-108.
2. Saito J. Pharmakologische Untersuchung des Ginkgogifts, des Dermatitiserregers in Ginkgo biloba L. Tohoku. J. Exp. Med. 16:1930;413-423.
3. Sowers W.F., Weary P.E., Collins O.D., Cawley E.P. Ginkgo-tree dermatitis. Arch. Derm. 91:1985;452-456.
4. Becker L.E., Skipworth G.B. Ginkgo tree dermatisis, stomatitis and proctitis. J. Am. Med. Assoc. 231:1975;1162.
5. Jirásek L., Brozková L. Profesionálni kontaktni precitlivelost na Ginkgo biloba L. (Occupational contact hypersensitivity to Ginkgo biloba L.). Cs. Derm. 56:1981;366-373.
6. Nakamura T. Ginkgo tree dermatitis. Contact Dermatitis. 12:1985;281-282.
7. Tomb R.R., Foussereau J., Sell Y. Mini-epidemic of contact dermatisis from ginkgo tree fruit (Ginkgo biloba L.). Contact Dermatitis. 19:1988;281-283.
8. Adawadkar P.D., El Sohly M.A. Isolation, purification and antimicrobial activity of anacardic acids from Ginkgo biloba fruits. Fitoterapia. 52:1981;129-135.
9. Lepoittevin J.P., Benezra C., Asakawa Y. Allergic contact dermatitis to Ginkgo biloba L.: relationship with urushiol. Arch. Dermatol. Res. 281:1989;227-230.
10. Saito F. Contact dermatitis due to Ginkgo fruit pulp: clinical survey, patchtest, LTT and animal sensitization. Hifu (Suppl.). 4:1987;155-168.
11. Hausen B.M. The sensitizing capacity of ginkgolic acids in guinea pigs. Am. J. Contact Dermatitis. 9:1998;146-148.
12. Gellerman J.L., Schlenk H. Methods for isolation and determination of anacardic acids. Anal. Chem. 40:1968;739-743.
13. Cartayrade A., Bourgeois G., Balz J.P., Carde J.P. The secretory apparatus of Ginkgo biloba: structure, differentiation and analysis of the secretory product. Trees. 4:1990;171-178.
14. Verotta L., Peterlongo F. Selective extraction of phenolic components from Ginkgo biloba extracts using supercritical carbon dioxide and off-line capillary gas chromatography/mass spectrometry. Phytochem. Anal. 4:1993;178-182.
15. Irie J., Murata M., Homma S. Glycero-3-phosphate dehydrogenase inhibitors, anacardic acids, from Ginkgo biloba. Biosci. Biotech. Biochem. 60:1996;240-243.
16. DeFeudis F.V. Ginkgo biloba extract (EGb 761). From chemistry to the clinic. 1998;Ullstein Medical, Wiesbaden.
17. Kammüller M.E., Thomas C., De Bakker J.M., Bloksma N., Seinen W. The popliteal lymph node assay in mice to screen for the immune disregulating potential of chemicals - a preliminary study. Int. J. Immunopharmacol. 11:1989;293-300.
18. Descotes J. The popliteal lymph node assay: a tool for studying the mechanisms of drug-induced autoimmune disorders. Toxicol. Lett. 64/65:1992;101-107.
19. Bloksma N., Kubicka-Muranyi M., Schuppe H.C., Gleichmann E., Gleichmann H. Predictive immunotoxicological test systems: suitability of the popliteal lymph node assay in mice and rats. Crit. Rev. Toxicol. 25:1995;369-396.
20. Hilton J., Kimber I. The murine local lymph node assay. O'Hare S., Atterwill C.K. In vitro toxicity testing protocols. 1995;227-235 Humana Press, Totowa, USA.
21. Gleichmann E. Studies on the mechanism of drug sensitization: T-cell-dependent popliteal lymph node reaction to diphenylhydantoin. Clin. Immunol. Immunopathol. 18:1981;203-211.
22. Marintchev A., Mirtcheva J., Sidjimov A., Haimova M. Induction of lymphoproliferative popliteal lymph node reaction by hydantoin derivatives: structure-activity relationships. Int. J. Immunopharmacol. 17:1995;981-984.
23. Basketter D.A., Cookman G., Gerberick G.F., Hamaide N., Potokar M. Skin sensitization thresholds: determination in predictive models. Food Chem. Toxicol. 35:1997;417-425.
24. Basketter D.A. Guinea pig predictive tests for contact hypersensitivity. Dean J.H., Luster M.I., Munson A.E., Kimber I. Immunotoxicology and immunopharmacology. 1994;693-702 Raven Press, New York.
25. Merk H Haut. Marquardt H., Schäfer S.G. Lehrbuch der Toxikologie. 1994;271-286 Wissenschaftsverlag, Mannheim.
26. Jaggy H., Koch E. Chemistry and biology of alkylphenols from Ginkgo biloba L. Pharmazie. 52:1997;735-738.
27. Woerdenbag H.J., Van Beek T.A. Ginkgo biloba. De Smet P.A.G.M., Keller K., Hänsel R., Chandler R.F. Adverse effects of herbal drugs. vol. 3:1997;51-66 Springer-Verlag, Berlin.
28. Benezra C. Plants causing adverse skin reactions. Plant flavonoids in biology and medicine II: biochemical, cellular, and medical properties. 1988;395-400 Alan R. Liss Inc, New York.