Niravoline, a selective kappa-opioid receptor agonist effectively reduces elevated intracranial pressure

Experimental Brain Research

Volumn 130, Issue 3, 2000, Pages 338-344

  Nagao, Seigo ^a   Bemana, Iraj ^a   Kuratani, Hiroko ^a   Takahashi, Eri ^a   Nakamura, Takehiro ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Brain edema; Cat; Cerebral perfusion pressure; Intracranial mass lesion; Intracranial pressure; Kappa opioid receptor agonist; Niravoline (RU 51599)

Indexed keywords

ELECTROLYTE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; NIRAVOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN WATER; CAT; CONTROLLED STUDY; DRUG RESPONSE; ELECTROENCEPHALOGRAPHY; ELECTROLYTE BLOOD LEVEL; FEMALE; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PLASMA OSMOLALITY; PRIORITY JOURNAL;

EID: 0033974222     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002219900251     Document Type: Article

References (35)

1. Armstrong WE, Wilson CJ, Gallagher MJ, Sladek CD (1988) The relationship between firing rates of supraoptic neurons and vasopressin release in vitro. In: Cowley AW Jr., Liard JF, Ausiello DA (eds) Vasopressin: cellular and integrative functions. Raven, New York, pp 355-361
2. Bellissant E, Denolle T, Sinnassamy P (1996) Systemic and regional hemodynamic and biological effects of a new kappa-opioid agonist, niravoline, in healthy volunteers. J Pharmacol Exp Ther 278:232-242
3. Bemana I, Nagao S (1998) Effects of niravoline (RU 51599), a selective kappa-opioid receptor agonist on intracranial pressure in gradually expanding extradural mass lesion. J Neurotrauma 15:117-124
4. Brooks DP, Giardina G, Gellai M (1993) Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther 266:164-171
5. Bullock R, Smiyh R, Favier J, Du Trevou M, Blake G (1985) Brain specific gravity and CT scan density measurement after human head injury. J Neurosurg 63:64-68
6. Faden AI (1986) Neuropeptides and central nervous system injury. Clinical implications. Arch Neurol 43:501-504
7. Gannon RC, Terrian DM (1991) U50, 488H inhibits dynorphin and glutamate release from guinea-pig hippocampal mossy fiber terminalis. Brain Res 548:242-247
8. Guenau C, Oberlander C (1997) The kappa opioid agonist niravoline decreases brain edema in the mouse middle cerebral artery occlusion model of stroke. J Pharmacol Exp Ther 282:1-6
9. Hall ED, Wolf DL, Althaus JS, Vonvoigtlander PF (1987) Beneficial effects of the kappa opioid receptor agonist U-50488H in experimental acute brain and spinal cord injury. Brain Res 435:174-180
10. Hamon G, Jouquey S (1990) Kappa agonists and vasopressin secretion. Horm Res 34:129-132
11. Hamon G, Clemence F, Fortin M (1994a) Niravoline hydrochloride, a novel selective kappa agonist with marked aquaretic properties but low analgesic potency (abstract). Br J Pharmacol [Suppl] 114:310
12. Hamon G, Fortin M, Le Martret O, Jouquey S, Vincent JC, Bichet DG (1994b) Pharmacological profile of niravoline, a new aquaretic compound (abstract). J Am Soc Nephrol 5:272
13. Hossmann KA (1982) Treatment of experimental cerebral ischemia. J Cereb Blood Flow Metab 2:275-297
14. Ikeda Y, Toda S, Kawamoto T, Teramoto A (1997a) Arginine vasopressin release inhibitor, RU 51599, attenuates brain oedema following transient forebrain ischemia in rats. Acta Neurochir (Wien) 139:1166-1172
15. Ikeda Y, Teramoto A, Nakagawa Y, Ishibashi Y, Yoshii T (1997b) Attenuation of cryogenic induced brain oedema by arginine vasopressin release inhibitor RU 51599. Acta Neurochir (Wien) 139:1173-1180
16. Jakobsson KE, Thuomas KA, Bergstorm K, Ponten U, Zwetnow NN (1990) Rebound of ICP after brain compression. An MRI study in dogs. Acta Neurochir (Wien) 104:126-135
17. Kusumoto K, Mackay KB, Mcculloch J (1992) The effect of the kappa-opioid receptor agonist CI-977 in a rat model of focal cerebral ischemia. Brain Res 576:147-151
18. Lambert PD, Barnes S, Hughes J, Woodruff GN, Hunter JC (1991) Inhibition of L-glutamate release: a possible mechanism of action for the neuroprotective effects of the kappa-selective agonist CI-977. Mol Neuropharmacol 1:77-82
19. Leander JD, Zerbe RL, Hart JC (1985) Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine. J Pharmacol Exp Ther 234:463-469
20. Lobato RD, Sarabia R, Cordobes F (1988) Posttraumatic cerebral hemispheric swelling. Analysis of 55 cases studied with computerized tomography. J Neurosurg 68:417-423
21. Macdonald RL, Werz MA (1986) Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurons. J Physiol 377:237-249
22. Mackay KB, Patel TR, Galbraith SL, Woodruff GN, Mcculloch J (1996) The relationship between glutamate release and cerebral blood flow after focal cerebral ischemia in the cat: effect of pretreatment with enadoline (a kappa receptor agonist). Brain Res 712:329-334
23. Marmarou A, Tanaka K, Shulman K (1982) An improved gravimetric measure of cerebral edema. J Neurosurg 56:246-253
24. Marmarou A, Barzo P, Fatouros P, Yamamoto T, Bullock R, Young H (1997) Traumatic brain swelling in head injured patients: brain edema or vascular engorgement? Acta Neurochir (Wien) [Suppl] 70:68-70
25. McIntosh TK, Head V, Faden AI (1987) Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat. Brain Res 425:225-233
26. Miller JD, Butterworth JF, Gudeman SK (1981) Further experience in the management of severe head injury. J Neurosurg 54:289-299
27. Oiso Y, Iwasaki Y, Kondo K, Takatsuki K, Tamita A (1988) Effect of the kappa-receptor agonist U50488H on the secretion of arginine vasopressin. Study on the mechanism of U50488H-induced diuresis. Neuroendocrinology 48:658-662
28. Peters GR, Ward NJ, Antal EG, Lai PY, Demaar EW (1987) Diuretic actions in man of a selective kappa opioid agonist: U-62,066E. J Pharmacol Exp Ther 240:128-131
29. Rossi NF (1995) The mechanisms of kappa-opioid agonist-induced water diuresis: central vs. peripheral actions. In: Saito T, Kurokawa K, Yoshida S (eds) Neurohypophysis: recent progress of vasopressin and oxytocin research. Elsevier, Tokyo, pp 289-299
30. Silvia RC, Slizgi GR, Ludens JH, Tang AH (1987) Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist. Brain Res 403: 52-57
31. Sinnassamy P, Sultan E, Bichet DG (1994) Aquaretic effect of niravoline (RU 51599), a kappa opioid agonist, in healthy volunteers (abstract). J Am Soc Nephrol 5:373
32. Tang AH (1985) Protection from cerebral ischemia by U-50448H, a specific kappa opioid analgesic agent. Life Sci 37: 1475-1482
33. Van De Heijning BJM, Koekkoek-Van Den Herik I, Maigret C, Van Wimersma Greidanus TJB (1991) Pharmacological assessment of the site of action of opioid on the release of vasopressin and oxytocin in the rat. Eur J Pharmacol 197:175-180
34. Yamada T, Nakao K, Itoh H (1988) Inhibitory action of leumorphin on vasopressin secretion in conscious rats. Endocrinology 122:985-990
35. Zhao BG, Chapman C, Bicknell RJ (1988) Opioid-noradrenergic interactions in the neurohypophysis. Neuroendocrinology 48: 16-24