Characterization of Carbon Disulfide Neurotoxicity in C57BL6 Mice: BehavioraL, Morphologic, and Molecular Effects

Toxicologic Pathology

Volumn 28, Issue 1, 2000, Pages 142-148

  Sills, R C ^a   Valentine, W M ^b   Moser, V ^c   Graham, D G ^b   Morgan, D L ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

axonal swelling; C57BL6 mice; carbon disulfide; cross linking spectrin; functional observational battery; neurofilament proteins; Peripheral neuropathy

Indexed keywords

CARBON DISULFIDE; NEUROFILAMENT PROTEIN; SPECTRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BODY POSTURE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FUNCTIONAL ASSESSMENT; GAIT; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PTOSIS; WEIGHT GAIN;

ADMINISTRATION, INHALATION; ANIMALS; BEHAVIOR, ANIMAL; CARBON DISULFIDE; CENTRAL NERVOUS SYSTEM; CROSS-LINKING REAGENTS; FEMALE; GAIT; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MOTOR ACTIVITY; NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM; PSYCHOMOTOR PERFORMANCE; SPECTRIN;

ANIMALIA; ATAXIA;

EID: 0033973711     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800118     Document Type: Article

References (26)

1. Aaserud O., Hommeren OJ, Tvedt B., Nakstad P., Mowe G., Efskind J., Russell D., Jorgensen EB, Nyberg-Hansen R., Rootwelt K., Gjerstad L. (1990). Carbon disulfide exposure and neurotoxic sequelae among viscose rayon workers. Am J Ind Med 18: 25-37.
2. Cavanagh JB (1982). The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: A question of rheology? Neuropathol Appl Neurobiol 8: 19-34.
3. Clark AW, Griffin JW, Price DL (1980). The axonal pathology in chronic IDPN intoxication. J Neuropathol Exp Neurol 39: 42-55.
4. Davidson M., Feinlab M. (1972). Carbon disulfide poisoning: A review. Am Heart J 83: 110-114.
5. Erve Jcl, Amarnath V., Graham DG, Sills RC, Morgan DL, Valentine WM (1998). Carbon disulfide and N, N-diethyldithiocarbamate generate thiourea cross-links on erythrocyte spectrin in vivo. Chem Res Toxicol 11: 544-549.
6. Erve Jcl, Amarnath V., Sills RC, Morgan DL, Valentine WM (1998). Characterization of a valine-lysine thiourea cross-link on rat globin produced by carbon disulfide or N, N-diethyldithiocarbamate in vivo. Chem Res Toxicol 11: 1128-1136.
7. Genter St. Clair MB, Amarnath V., Moody MA, Anthony DC, Anderson CW, Graham DG (1998). Pyrrole oxidation and protein cross-linking as necessary steps in the development of y-diketones. Chem Res Toxicol 1: 179-185.
8. Gottfried MR, Graham DG, Morgan M., Casey HW, Bus JS (1985). The morphology of carbon disulfide neurotoxicity. Neurotoxicology 6: 89-96.
9. Graham DG, Amarnath V., Valentine WM, Pyle SJ, Anthony DC (1995). Pathogenetic studies of hexane and carbon disulfide neurotoxicity. CRC Crit Rev Toxicol 25: 91-112.
10. Harry GJ, Graham DG, Valentine WM, Morgan DL, Sills RC (1998). Carbon disulfide neurotoxicity in rats: VIII. Summary. Neurotoxicology 19: 159-162.
11. Hoffman PN, Lasek RJ (1975). The slow component of axonal transport. J Cell Biol 66: 351-366.
12. Johnson DJ, Graham DG, Amarnath V., Amarnath K., Valentine WM (1996). The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. Chem Res Toxicol 9: 910-916.
13. Johnson DJ, Graham DG, Amarnath V., Amarnath K., Valentine WM (1998). Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N, N-diethyldithiocarbamate. Toxicol Appl Pharmacol 148: 288-296.
14. Laemmli U. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
15. Lewis JG, Graham DG, Valentine WM, Morris RW, Morgan DL, Sills RC (1999). Exposure of C57BL6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet. Toxicol Sci 49: 124-132.
16. McDaniel KL, Moser VC (1993). Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin. Neurotoxicol Teratol 15: 71-83.
17. Moser VC, Becking GC, MacPhail RC, Kulig BM (1997). The IPCS collaborative study on neurobehavioral screening methods. Fundam Appl Toxicol 35: 143-151.
18. Moser VC, Phillips PM, Morgan DL, Sills RC (1998). Carbon disulfide neurotoxicity in rats: VII. Behavioral evaluations using a functional observational batttery. Neurotoxicology 19: 147-158.
19. Shell L., Rozum M., Jortner BS, Ehrich M. (1992). Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination. Neurotoxicol Teratol 14: 273-283.
20. Sills RC, Harry GJ, Morgan DL, Valentine WM, Graham DG (1998). Carbon disulfide neurotoxicity in rats: V. Morphology of axonal swelling in the muscular branch of the posterior tibial nerve and spinal cord. Neurotoxicology 19: 117-128.
21. Sills RC, Morgan DL, Harry GJ (1998). Carbon disulfide neurotoxicity in rats: 1. Introduction and study design. Neurotoxicology 19: 83-88.
22. Spencer PS, Schaumburg HH (1976). Central-peripheral distal axonopathy—The pathology of dying-back polyneuropathies. In: Progress in Neuropathology, Zimmerman HM (ed). Grune & Stratton, New York, pp 253-295.
23. Spencer PS, Schaumburg HH (1977). Ultrastructural studies of the dying-back process. IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathies. J Neuropathol Exp Neurol 36: 300-320.
24. Tepper JS, Moser VC, Costa DL, Mason MA, Roache N., Guo Z., Dyer RS (1995). Toxicological and chemical evaluation of emissions from carpet samples. Am Ind Hyg Assoc J 56: 158-170.
25. Valentine WM, Amarnath V., Amarnath K., Erve Jcl, Graham DG, Morgan DL, Sills RC (1998). Covalent modification of hemoglobin by carbon disulfide: III. A potential biomarker of effect. Neurotoxicology 19: 99-108.
26. Valentine WM, Amarnath V., Graham DG, Morgan DL, Sills RC (1997). CS2-mediated cross-linking of erythrocyte spectrin and neurofilament protein: Dose response and temporal relationship to the formation of axonal swellings. Toxicol Appl Pharmacol 142: 95-105.