-
1
-
-
0020033909
-
New ring-hydroxylated metabolites of propranolol: Species differences and stereospecific 7-hydroxylation
-
Walle T, Oatis JE Jr, Walle UK, Knapp DR. New ring-hydroxylated metabolites of propranolol: species differences and stereospecific 7-hydroxylation. Drug Metab Dispos, 1982;10:122-127
-
(1982)
Drug Metab Dispos
, vol.10
, pp. 122-127
-
-
Walle, T.1
Oatis Jr., J.E.2
Walle, U.K.3
Knapp, D.R.4
-
2
-
-
0020582041
-
Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques
-
Bargar EM, Walle UK, Bai SA, Walle T. Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques. Drug Metab Dispos, 1983;11:266-272
-
(1983)
Drug Metab Dispos
, vol.11
, pp. 266-272
-
-
Bargar, E.M.1
Walle, U.K.2
Bai, S.A.3
Walle, T.4
-
3
-
-
0024425453
-
The effects of the propranolol enantiomers on the intracardiac electrophysiological activities of Langendorff perfused hearts
-
Stark G, Stark U, Lueger A, Bertuch H, Pilger E, Pietsch B, Tritthart HA, Lindner W. The effects of the propranolol enantiomers on the intracardiac electrophysiological activities of Langendorff perfused hearts. Basic Res Cardiol, 1989;84:461-468
-
(1989)
Basic Res Cardiol
, vol.84
, pp. 461-468
-
-
Stark, G.1
Stark, U.2
Lueger, A.3
Bertuch, H.4
Pilger, E.5
Pietsch, B.6
Tritthart, H.A.7
Lindner, W.8
-
4
-
-
0027440404
-
Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes
-
Masubuchi Y, Yamamoto LA, Uesaka M, Fujita S, Narimatsu S, Suzuki T. Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes. Biochem Pharmacol, 1993;46:1759-1765
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 1759-1765
-
-
Masubuchi, Y.1
Yamamoto, L.A.2
Uesaka, M.3
Fujita, S.4
Narimatsu, S.5
Suzuki, T.6
-
5
-
-
0019849296
-
Glucuronidation of propranolol and 4′-hydroxypropranolol. Substrate specificity and stereoselectivity of rat liver microsomal glucuronyltransferases
-
Thompson JA, Hull JE, Norris KJ. Glucuronidation of propranolol and 4′-hydroxypropranolol. Substrate specificity and stereoselectivity of rat liver microsomal glucuronyltransferases. Drug Metab Dispos, 1981;9: 466-471
-
(1981)
Drug Metab Dispos
, vol.9
, pp. 466-471
-
-
Thompson, J.A.1
Hull, J.E.2
Norris, K.J.3
-
6
-
-
0018836994
-
Roles of hepatic blood flow and enzyme activity in the kinetics of propranolol and sotalol
-
Pirttiaho HI, Sotaniemi EA, Pelkonen RO, Pitkanen U, Anttila M, Sundqvist H. Roles of hepatic blood flow and enzyme activity in the kinetics of propranolol and sotalol. Br J Clin Pharmacol, 1980;9:399 -405
-
(1980)
Br J Clin Pharmacol
, vol.9
, pp. 399-405
-
-
Pirttiaho, H.I.1
Sotaniemi, E.A.2
Pelkonen, R.O.3
Pitkanen, U.4
Anttila, M.5
Sundqvist, H.6
-
7
-
-
0029796447
-
Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver
-
Hickey PL, McLean AJ, Angus PW, Choo EF, Morgan DJ. Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver. Gastroenterology, 1996;111:1039 -1048
-
(1996)
Gastroenterology
, vol.111
, pp. 1039-1048
-
-
Hickey, P.L.1
McLean, A.J.2
Angus, P.W.3
Choo, E.F.4
Morgan, D.J.5
-
8
-
-
0024993542
-
Propranolol oxidation by human liver microsomes - The use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity
-
Otton SV, Gillam EM, Lennard MS, Tucker GT, Woods HF. Propranolol oxidation by human liver microsomes - the use of cumene hydroperoxide to probe isoenzyme specificity and regio-and stereoselectivity. Br J Clin Pharmacol, 1990;30:751-760
-
(1990)
Br J Clin Pharmacol
, vol.30
, pp. 751-760
-
-
Otton, S.V.1
Gillam, E.M.2
Lennard, M.S.3
Tucker, G.T.4
Woods, H.F.5
-
9
-
-
0026769890
-
Induction of propranolol metabolism by the azo dye sudan III in rats
-
Ishida R, Obara S, Masubuchi Y, Narimatsu S, Fujita S, Suzuki T. Induction of propranolol metabolism by the azo dye sudan III in rats. Biochem Pharmacol, 1992;43:2489-2492
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 2489-2492
-
-
Ishida, R.1
Obara, S.2
Masubuchi, Y.3
Narimatsu, S.4
Fujita, S.5
Suzuki, T.6
-
10
-
-
0021672722
-
Stereoselectivity in the aromatic hydroxylation of propranolol in the rat: Use of deuterium labeling and pseudoracemic mixtures
-
Nelson WL, Bartels MJ. Stereoselectivity in the aromatic hydroxylation of propranolol in the rat: use of deuterium labeling and pseudoracemic mixtures. Drug Metab Dispos, 1984;12:382-384
-
(1984)
Drug Metab Dispos
, vol.12
, pp. 382-384
-
-
Nelson, W.L.1
Bartels, M.J.2
-
12
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Bio Chem, 1951;193: 265-275
-
(1951)
J Bio Chem
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
13
-
-
0027225371
-
In vivo evidence that theophylline is metabolized principally by CYP1A in rats
-
Bachmann K, Sanyal G, Potter J, Schiavone R, Loch J. In vivo evidence that theophylline is metabolized principally by CYP1A in rats. Pharmacology, 1993;47:1-7
-
(1993)
Pharmacology
, vol.47
, pp. 1-7
-
-
Bachmann, K.1
Sanyal, G.2
Potter, J.3
Schiavone, R.4
Loch, J.5
-
14
-
-
0029877953
-
The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes
-
Takahashi N, Harttig U, Williams DE, Bailey GS. The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes. Carcinogenesis, 1996;17:79-87
-
(1996)
Carcinogenesis
, vol.17
, pp. 79-87
-
-
Takahashi, N.1
Harttig, U.2
Williams, D.E.3
Bailey, G.S.4
-
15
-
-
0028787788
-
Oxidative metabolism of zolpidem by human liver cytochrome P450S
-
Pichard L, Gillet G, Bonfils C, Domergue J, Thenot JP, Maurel P. Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug Metab Dispos, 1995;23:1253-1262
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 1253-1262
-
-
Pichard, L.1
Gillet, G.2
Bonfils, C.3
Domergue, J.4
Thenot, J.P.5
Maurel, P.6
-
16
-
-
0029011523
-
Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabololism
-
ChangTK, Chen G, Waxman DJ. Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabololism. J Pharmacol Exp Ther, 1995;274:270-275
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 270-275
-
-
Chang, T.K.1
Chen, G.2
Waxman, D.J.3
-
17
-
-
0028520665
-
Hepatic cytochrome P450 2B induction by ethyl/phenyl-substituted congeners of phenobarbital in the B6C3F1 mouse
-
Nims RW, Lubet RA, Diwan BA, Mellini DW, Utermahlen WE Jr, Thomas PE. Hepatic cytochrome P450 2B induction by ethyl/phenyl-substituted congeners of phenobarbital in the B6C3F1 mouse. J Biochem Toxicol, 1994;9:269-278
-
(1994)
J Biochem Toxicol
, vol.9
, pp. 269-278
-
-
Nims, R.W.1
Lubet, R.A.2
Diwan, B.A.3
Mellini, D.W.4
Utermahlen Jr., W.E.5
Thomas, P.E.6
-
18
-
-
0025311273
-
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase
-
Capdevila JH, Karara A, Waxman DJ, Martin MV, Falck JR, Guenguerich FP. Cytochrome P-450 enzyme-specific control of the regio-and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. J Biol Chem, 1990;265:10865-10871
-
(1990)
J Biol Chem
, vol.265
, pp. 10865-10871
-
-
Capdevila, J.H.1
Karara, A.2
Waxman, D.J.3
Martin, M.V.4
Falck, J.R.5
Guenguerich, F.P.6
-
19
-
-
0027438563
-
Regio- and stereoselective propranolol metabolism by 15 forms of purified cytochromes P-450 from rat liver
-
Fujita S, Umeda S, Funae Y, Imaoka S, Abe H, Ishida R, Adachi T, Masuda M, Kazusaka A, Suzuki T. Regio-and stereoselective propranolol metabolism by 15 forms of purified cytochromes P-450 from rat liver. J Pharmacol Exp Ther, 1993;264:226-233
-
(1993)
J Pharmacol Exp Ther
, vol.264
, pp. 226-233
-
-
Fujita, S.1
Umeda, S.2
Funae, Y.3
Imaoka, S.4
Abe, H.5
Ishida, R.6
Adachi, T.7
Masuda, M.8
Kazusaka, A.9
Suzuki, T.10
-
20
-
-
0030028540
-
Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2
-
Ching MS, Bichara N, Blake CL, Ghabrial H, Tukey RH, Smallwood RA. Propranolol 4-and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2. Drug Metab Dispos, 1996;24:692-694
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 692-694
-
-
Ching, M.S.1
Bichara, N.2
Blake, C.L.3
Ghabrial, H.4
Tukey, R.H.5
Smallwood, R.A.6
-
21
-
-
0029145903
-
Drug interactions and the cytochrome P450 system. The role of cytochrome P4501A2
-
Brosen K. Drug interactions and the cytochrome P450 system. The role of cytochrome P4501A2. Clin Pharmacokinet, 1995;29(Suppl 1):20 -25
-
(1995)
Clin Pharmacokinet
, vol.29
, Issue.1 SUPPL.
, pp. 20-25
-
-
Brosen, K.1
-
22
-
-
0028020099
-
Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase
-
Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M, Narimatsu S. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos, 1994;22:909-915
-
(1994)
Drug Metab Dispos
, vol.22
, pp. 909-915
-
-
Masubuchi, Y.1
Hosokawa, S.2
Horie, T.3
Suzuki, T.4
Ohmori, S.5
Kitada, M.6
Narimatsu, S.7
-
23
-
-
0029793848
-
Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes
-
Rowland K, Ellis SW, Lennard MS, Tucker GT. Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes. Br J Clin Pharmacol, 1996;42:390-393
-
(1996)
Br J Clin Pharmacol
, vol.42
, pp. 390-393
-
-
Rowland, K.1
Ellis, S.W.2
Lennard, M.S.3
Tucker, G.T.4
-
24
-
-
0028956887
-
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers - N-desisopropylation is mediated mainly by CYP1A2
-
Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T. Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers - N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol, 1995;39:421-431
-
(1995)
Br J Clin Pharmacol
, vol.39
, pp. 421-431
-
-
Yoshimoto, K.1
Echizen, H.2
Chiba, K.3
Tani, M.4
Ishizaki, T.5
-
25
-
-
0030572727
-
Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats
-
Narimatsu S, Mochida M, Matsumoto T, Masubuchi Y, Horie T, Nagata K, Funae Y, Cho AK, Suzuki T. Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats. Chem Biol Interact, 1996;101:207-224
-
(1996)
Chem Biol Interact
, vol.101
, pp. 207-224
-
-
Narimatsu, S.1
Mochida, M.2
Matsumoto, T.3
Masubuchi, Y.4
Horie, T.5
Nagata, K.6
Funae, Y.7
Cho, A.K.8
Suzuki, T.9
-
26
-
-
0027440404
-
Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes
-
Masubuchi Y, Yamamoto LA, Uesaka M, Fujita S, Narimatsu S, Suzuki T. Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes. Biochem Pharmacol, 1993;46:1759-1765
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 1759-1765
-
-
Masubuchi, Y.1
Yamamoto, L.A.2
Uesaka, M.3
Fujita, S.4
Narimatsu, S.5
Suzuki, T.6
|