HCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21

Molecular Human Reproduction

Volumn 6, Issue 1, 2000, Pages 5-10

  Jauniaux, E ^a   Bao, S ^b   Eblen, A ^b   Li, X ^b   Lei, Z M ^b   Meuris, S ^c   Rao, Ch V ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b University of Louisville School of Medicine   (United States)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

HCG; Placenta; Pregnancy; Receptors; Trisomy

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT; CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTROPHOBLAST; FETUS; GONADOTROPIN BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TISSUE LEVEL; TRISOMY 18; TRISOMY 21; TROPHOBLAST;

EID: 0033973502     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/6.1.5     Document Type: Article

References (28)

1. Abbas, A., Chard, T. and Nicolaides, K. (1995) Fetal and maternal hCG concentration in aneuploid pregnancies. Br. J. Obstet. Gvnaecol., 102, 561-563.
2. Angerer, L.M., Cox, K.H. and Angerer, R.C. (1987) Demonstration of tissue specific gene expression by in situ hybridization. Methods Enzymol., 152, 649-661.
3. Brizot, ML., Snijders, R.J.M., Butler, J. et al. (1995a) Maternal serum hCG and fetal nuchal translucency thickness for the prediction of fetal trisomies in the first trimester of pregnancy. Br. J. Obstet. Gynaecol., 102, 127-132.
4. Brizot, M.L., Jauniaux, E., Mckie, A.T. et al. (1995b) Placental expression of α and β subunits of human chorionic gonadotrophin in early pregnancies with Down syndrome. Hum. Reprod., 10, 2506-2509.
5. Brizot, M.L., Jauniaux, E., Mckie, A.T. et al. (1996) Placental mRNA expression of α and β human chorionic gonadotrophin in early trisomy 18 pregnancies. Mol. Hum. Reprod., 2, 463-465.
6. Chard, T. (1991) Biochemistry and endocrinology of the Down's syndrome pregnancy. Ann. N.Y. Acad. Sci., 626, 580-596.
7. Eldar-Geva, T., Hochberg, A., deGroot, N. and Weinstein, D. (1995) High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level in trophoblasts. J. Clin. Endocrinol. Metab., 80, 3528-3531.
8. Exterman, P., Bischof, P., Marguerat, P. and Mermillod, B. (1998) Second-trimester maternal serum screening for Down's syndrome: free β-human chorionic gonadotrophin (HCG) and alphafetoprotein, with or without unconjugated oestriol, compared with total HCG, alphafetoprotein and unconjugated oestriol. Hum. Reprod., 13, 220-223.
9. Fiddes, J.C. and Goodman, H.M. (1979) Isolation, cloning and sequence analysis of the cDNA for the α-subunit of the human chorionic gonadotropin. Nature, 281, 351-356.
10. Hay, D.L. (1988) Placental histology and the production of human choriogonadotrophin and its subunits in pregnancy. Br. J. Obstet. Gynaecol., 95, 1268-1275.
11. Hoshina, M., Boothby, M., Pattillo, R. et al. (1985) Linkage of human chorionic gonadotropin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. Placenta, 6, 163-172.
12. Jameson, J.L. and Hollenberg, A.N. (1993) Regulation of chorionic gonadotropin gene expression. Endocr. Rev., 14, 203-221.
13. Jauniaux, E. and Hustin, J. (1998) Chromosomally abnormal early ongoing pregnancies: Correlation of ultrasound and placental histological findings. Hum. Pathol., 29, 1195-1199.
14. Jauniaux, E., Nicolaides, K.H., Nagy, A.-M. et al. (1996) Total amount of circulating human chorionic gonadotropin α and β subunits in first trimester trisomies 21 and 18. J. Endocrinol. 148, 27-31.
15. Lapthorn, A.J., Harris, D.C., Littlejohn, A. et al. (1994) Crystal structure of human chorionic gonadotropin. Nature, 369, 455-461.
16. Licht, P., Cao, H., Lei, Z.M. et al. (1993a) Novel self-regulation of human chorionic gonadotropin biosynthesis in term pregnancy human placenta. Endocrinology, 133, 3014-3025.
17. Licht, P., Cao, H., Lei, Z.M. et al. (1993b) Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. J. Clin. Endocrinol. Metab., 78, 1188-1194.
18. Licht, P., Losch, A., Dittrich, R. et al. (1998) Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis. Hum. Reprod. Update, 4, 532-538.
19. Morrish, D.W., Marusyk, H. and Siy, O. (1987) Demonstration of specific secretory granules for human chorionic gonadotropin in placenta. J. Histochem. Cytochem., 35, 93-101.
20. Nagy, A.M., Meuris, S. and Robyn, C. (1989) Inventory of the molecular heterogeneity of purified human chorionic gonadotrophin preparations as revealed by immunoelectrotransfer. Med. Sci. Res., 17, 771-773.
21. Nagy, A.-M., Glinoer, D., Delogne-Desnoeck, et al. (1994) Total amounts of circulating α and β subunits can be assessed throughout pregnancy using immunoradiometric assay calibrated with the unaltered and thermally dissociated heterodimer. J. Endocrinol., 140, 513-520.
22. Rao, Ch.V. (1996) The beginning of a new era in reproductive biology and medicine: Expression of low levels of functional luteinizing hormone/ human chorionic gonadotropin receptors in nongonadal tissues. J. Physiol. Pharmacol., 47, 41-53.
23. Rao, Ch.V. and Sanfilippo, J.S. (1997) New understanding in the biochemistry of implantation: Potential direct roles of luteinizing hormone and human chorionic gonadotropin. Endocrinologist. 7, 107-111.
24. Reshef, E., Lei, Z.M., Rao, Ch.V. et al. (1990) The presence of gonadotropin receptors in non-pregnant human uterus, human placenta, fetal membranes and decidua. J. Clin. Endocrinol. Metab., 70, 421-429.
25. Shi, Q.J., Lei, Z.M., Rao, Ch.V. and Lin, J. (1993) Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblast. Endocrinology, 132, 1387-1395.
26. Spencer, K. (1993) Free α-subunit human chorionic gonadotropin in Down syndrome. Am. J. Obstet. Gynecol. 168, 132-135.
27. Talmadge, K., Boorstein, W.R. and Fiddes, J.C. (1983) The human genome contains seven genes for the β-subunit of chorionic gonadotropin but only one gene for the β-subunit of luteinizing hormone. DNA, 2, 281-289.
28. Tao, Y.X., Lei, Z.M., Hofmann, G.E. and Rao, Ch. V. (1995) Human intermediate trophoblasts express gonadotropin/luteinizing hormones receptor gene. Biol. Reprod., 53, 591-597.