Proteolysis of Plasmodium falciparum surface antigen, Pfs230, during gametogenesis

Molecular and Biochemical Parasitology

Volumn 106, Issue 1, 2000, Pages 77-82

  Brooks, S R ^a   Williamson, K C ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Antigens; Falciparum; Malaria; Parasite proteases; Pfs230; Plasmodium falciparum sexual stage proteins; Stage specific processing; Surface

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; METALLOPROTEINASE INHIBITOR; PROTOZOAL PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ERYTHROCYTE; GAMETOCYTE; GAMETOGENESIS; LIFE CYCLE; NONHUMAN; PEPTIDE MAPPING; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; TROPHOZOITE;

ANIMALS; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; CYSTEINE ENDOPEPTIDASES; DIMETHYL SULFOXIDE; GAMETOGENESIS; GERM CELLS; IMMUNOBLOTTING; PEPSTATINS; PHENANTHROLINES; PHENYLMETHYLSULFONYL FLUORIDE; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; XANTHURENATES;

EID: 0033972528     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00201-7     Document Type: Article

References (23)

1. Alano P., Carter R. Sexual differentiation in malaria parasites. Annu. Rev. Microbiol. 44:1990;429-449.
2. Quakyi I.A., Carter R., Rener J., Kumar N., Good M.F., Miller L.H. The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies. J. Immunol. 139:1987;4213-4217.
3. Carter R, Graves PM. Gametocytes, In: Wernsdorfer WH, McGregor I, editors. Malaria: Principles and Practice of Malariology, vol. 1, 1988. p. 253-320.
4. Garcia G.E., Wirtz R.A., Barr J.R., Woolfitt A., Rosenberg R. Xanthurenic acid induces gametogenesis in Plasmodium, the malaria parasite. J. Biol. Chem. 273:1998;12003-12005.
5. Billker O., Lindo V., Panico M., Etienne A.E., Paxton T., Dell A., Rogers M., Sinden R.E., Morris H.R. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito. Nature. 392:1998;289-292.
6. 2+ and cGMP as mediators of the exflagellation of Plasmodium berghei and Plasmodium falciparum. Mol. Biochem. Parasitol. 42:1990;101-108.
7. Ogwan'g R., Mwangi J., Gachihi G., Nwachukwu A., Roberts C.R., Martin S.K. Use of pharmacological agents to implicate a role for phosphoinositide hydrolysis products in malaria gamete formation. Biochem. Pharmacol. 46:1993;1601-1606.
8. Ogwan'g R.A., Mwangi J.K., Githure J., Were J.B., Roberts C.R., Martin S.K. Factors affecting exflagellation of in vitro-cultivated Plasmodium falciparum gametocytes. Am. J. Trop. Med. Hyg. 49:1993;25-29.
9. Williamson K.C., Fujioka H., Aikawa M., Kaslow D.C. Stage-specific processing of Pfs230, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol. Biochem. Parasitol. 78:1996;161-169.
10. Williamson K.C., Keister D.B., Muratova O., Kaslow D.C. Recombinant Pfs230, a Plasmodium falciparum gametocyte protein, induces antisera that reduce the infectivity of Plasmodium falciparum to mosquitoes. Mol. Biochem. Parasitol. 75:1995;33-42.
11. Ifediba T., Vanderberg J.P. Complete in vitro maturation of Plasmodium falciparum gametocytes. Nature. 294:1981;364-366.
12. Vincent AA, Fanning S, Caira FC, Williamson KC. Immunogenicity of malaria transmission-blocking vaccine candidate, y230.CA14 following crosslinking in the presence of tetanus toxoid. Parasite Immunol. 21:1999;573-581.
13. Bailly E., Jambou R., Savel J., Jaureguiberry G. Plasmodium falciparum: differential sensitivity in vitro to E-64 (cysteine protease inhibitor) and pepstatin A (aspartyl protease inhibitor). J. Protozool. 39:1992;593-599.
14. Rosenthal P.J., McKerrow J.H., Aikawa M., Nagasawa H., Leech J.H. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J. Clin. Invest. 82:1988;1560-1566.
15. Barrett A.J., Kembhavi A.A., Brown M.A., Kirschke H., Knight C.G., Tamai M., Hanada K. l-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201:1982;189-198.
16. McGowan E.B., Becker E., Detwiler T.C. Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem. Biophys. Res. Commun. 158:1989;432-435.
17. Lang-Unnasch N., Murphy A.D. Metabolic changes of the malaria parasite during the transition from the human to the mosquito host. Annu. Rev. Microbiol. 52:1998;561-590.
18. Saliba K.J., Kirk K. Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway. Mol. Biochem. Parasitol. 94:1998;297-301.
19. Rosenthal P.J., Kim K., McKerrow J.H., Leech J.H. Identification of three stage-specific proteinases of Plasmodium falciparum. J. Exp. Med. 166:1987;816-821.
20. Braun-Breton C., Blisnick T., Morales-Betoulle M.E., Barale J.C., Langsley G. Malaria parasites: enzymes involved in red blood cell invasion. Braz. J. Med. Biol. Res. 27:1994;363-367.
21. McKerrow J.H. et al. The proteases and pathogenicity of parasitic protozoa. Annu. Rev. Microbiol. 47:1993;821-853.
22. Barale J.C., Blisnick T., Fujioka H., Alzari P.M., Aikawa M., Braun-Breton C., Langsley G. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase. Proc. Natl. Acad. Sci. USA. 96:1999;6445-6450.
23. Blackman M.J., Fujioka H., Stafford W.H., Sajid M., Clough B., Fleck S.L., Aikawa M., Grainger M., Hackett F. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites. J. Biol. Chem. 273:1998;23398-23409.