Concentration of iron and distribution of iron and transferrin after experimental iron overload in rat tissues in vivo: Study of the liver, the spleen, the central nervous system and other organs

Pathology Research and Practice

Volumn 196, Issue 1, 2000, Pages 47-54

  Papanastasiou, Dimitris A ^a   Vayenas, Dimitris V ^a   Vassilopoulos, Andreas ^a   Repanti, Maria ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY GENERAL HOSPITAL OF PATRAS   (Greece)

Author keywords

Hemochromatosis; Iron; Transferrin

Indexed keywords

HEMOSIDERIN; IRON; TRANSFERRIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; MALE; MICROSCOPIC ANATOMY; NONHUMAN; RAT; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION;

EID: 0033972391     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(00)80021-7     Document Type: Article

References (28)

1. APHA, AWWA, and WPCF (1989) Standard Methods for the Examination of Water and Waste water, 17th edition. American Public Health Association and Water Pollution Control Federation, Washington, D. C.
2. Bacon BR, Tavill AS, Brittenham GM, Park CH, Reknagel RD (1983) Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71: 429-439
3. Bothwell TH. Bradlow BA (1960) Siderosis in the Bantu: a combined histopathologic and chemical study. Arch Pathol 70: 279-292
4. Bothwell TH, Abrahams C, Bradlow BA, Charlton RW (1965) Idiopathic and Bantu hemochromatosis: comparative histological study. Arch Pathol 79: 163-168
5. Brissot P, Campion JP, Guillouzo A, Allain H, Messner M, Simon M, Ferrand B, Bourel M (1983) Experimental hepatic iron overload in the baboon: results of a two-year study. Evolution of biological and morphological hepatic parameters of iron overload. Dig Dis Sci 28: 616-624
6. Chang H-Y, Robbins SL, Mallory GK (1959) Prolonged intravenous administration of iron to normal and anaemic rabbits. Lab Invest 8: 1-18
7. Connor JR, Philips TM, Lakshman MR, Barron KD, Fine RE, Csiza CK (1987) Regional variation in the levels of transferrin in the CNS of normal and myelin-deficient rats. J Neurochem 49: 1523-1529
8. De Vos R, Sciot R, van Eyken P, Desmet VJ (1988) Immunoelectron microscopic localization of hepatic transferrin receptors in human liver with and without iron overload. Virch Arch B Cell Pathol 55: 11-17
9. Dickinson TK, Devenyi AG, Connor JR (1996) Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice. J Lab Clin Med 128: 270-278
10. Dion TL, Markelonis GJ, Oh TH, Bregman BS, Pugh MA, Hobbs SL, Kim YC (1988) Immunocytochemical localization of Transferrin and Mitochrondrial Malate Dehydrogenase in the Developing Nervous System of the Rat. Dev Neurosci 10: 152-164
11. Iancu TC, Landing BH, Neustein HB (1977) Pathogenetic mechanism in hepatic cirrhosis of thalassaemia major: Light and electron microscopic studies. Pathol Annu 12: 171-200
12. Iancu TC, Rabinowitz H, Brissot P, Guillouzo A, Deugnier Y, Bourel M (1985) Iron overload of the liver in the baboon. An ultrastructural study. J Hepatol 1: 261-275
13. Isaacson C, Seftel HL, Keeley KJ, Bothwell TH (1961) Siderosis in the Banut: the relationship between iron overload and cirrhosis. J Lab Clin Med 58: 845-853
14. Kahnke MJ (1966) Atomic Absorption Spectrophotometry Applied to the determination of Zinc in Formalised Human Tissue. At Absorb Newsl 5:7-15
15. Koeppen AH, Dickon AC, McEvoy JA (1995) The heterogeneous distribution of brain transferrin. J Neuropathol Exp Neurol 54: 395-403
16. Lombard M, Bomford A, Hynes M, Naoumov NV, Roberts S, Crowe J, Williams R (1989) Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology 9: 1-5
17. Moos T, Mollgard K (1993) A sensitive post-DAB enhancement technique for demonstration of iron in the central nervous system. Histochemistry 99: 471-475
18. Oliver RAM (1959) Siderosis following transfusions of blood. J Pathol 77: 171-178
19. Park CH, Bacon BR, Brittenham GM, Tavill AS (1987) Pathology of dietary carbonyl iron overload in rats. Lab Invest 5: 555-563
20. Parker MM, Humoller FL, Mahler DJ (1967) Determination of Copper and Zinc in Biological Material. Clin Chem 13: 40-48
21. Pechet GS (1969) Parenteral iron overload. Organ and cell distribution in rats. Lab Invest 20: 119-126
22. Pietrangelo A, Rocchi E, Schraffonati L, Ventura E, Cairo G (1990) Liver gene expression during chronic dietary iron overload in rats. Hepatology 11: 798-804
23. Pietrangelo A, Rocchi E, Ferrari A, Ventura E, Cairo G (1991) Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis. Hepatology 14: 1083-1088
24. Ridson RA, Barry M, Flynn DM (1975) Transfusional iron overload: The relationship between tissue iron concentration and hepatic fibrosis in thalassaemia. J Pathol 116: 83-95
25. Sciot R, Paterson AC, Van den Oord SS, Desmet VJ (1987) Lack of hepatic transferrin receptor expression in hemochromatosis. Hepatology 7: 831-837
26. Selden C, Owen M. Hopkins JMP, Peters TJ (1980) Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosome disruption. Br J Hematol 44: 593-603
27. Taylor EM, Crowe A, Morgan EH (1991) Transferrin and iron uptake by the brain: Effects of altered iron status. J Neurochem 57: 1584-1592
28. Wheatherall DJ, Glegg JB (1981) The Thalassaemia Syndromes. 3rd ed. Blackwell Scientific Publications, Oxford, England