Enantiospecific determination of PNU-83894 and its major metabolite, PNU-83892, in plasma, and its application to the characterization of the enantioselective pharmacokinetics of PNU-83894 in the dog

Journal of Chromatography A

Volumn 871, Issue 1-2, 2000, Pages 201-206

  Zhong, Wei Zhu ^a   Williams, Marta G ^a  

^a Drug Metabolism Research   (United States)

Author keywords

Aminocyclohexyldichlorobenzamide; Dichloromethylaminocyclohexylbenzamide; Enantiomer separation; PNU 83892; PNU 83894

Indexed keywords

PNU 83892; PNU 83894; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG DETERMINATION; DRUG METABOLISM; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STEREOCHEMISTRY; STEREOSPECIFICITY;

ANIMALS; BENZAMIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXYLAMINES; DOGS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

ANIMALIA; CANIS FAMILIARIS;

EID: 0033972110     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(99)00859-6     Document Type: Article

References (7)

1. Von Voigtlander P.F., Hall E.D., Ochoa M.C., Lewis R.A., Triezenberg H.J. J. Pharmacol. Exp. Ther. 243:1987;542.
2. Zhong W.Z., Williams M.G. Pharm. Res. 11:1994;1524.
3. Zhong W.Z., Williams M.G. J. Pharm. Sci. 82:1993;1049.
4. Zhong W.Z., Williams M.G., Schuette M.R., Van de Giessen T.L., Jones B.W. Enantiomer. 1:1996;89.
5. Hinze W.L., Riehl T.E., Armstrong D.W., DeMond W., Alak A., Ward T. Anal. Chem. 57:1985;237.
6. Armstrong D.W., DeMond W. J. Chromatogr. Sci. 22:1984;411.
7. Gibaldi M., Perrier D. Pharmacokinetics. 2nd ed. 1982;411 Marcel Dekker, New York.