Are randomized trials of hormone replacement therapy in symptomatic women with breast cancer feasible?

Fertility and Sterility

Volumn 73, Issue 2, 2000, Pages 292-299

  Marsden, Jo ^a,b,c   Whitehead, Malcolm ^a,e   A’Hern, Roger ^a   Baum, Mike ^a,d   Sacks, Nigel ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c MAYDAY UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Breast cancer survivors; Estrogen deficiency symptoms; HRT; Randomized trials

Indexed keywords

ESTRADIOL; ESTRADIOL VALERATE; ESTRADIOL VALERATE PLUS NORGESTREL; TAMOXIFEN; TIBOLONE;

ADULT; ARTICLE; BREAST CANCER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTROGEN DEFICIENCY; FEMALE; HORMONE SUBSTITUTION; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; METASTASIS; PATIENT ATTITUDE; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SIDE EFFECT; SYMPTOM;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; PATIENT ACCEPTANCE OF HEALTH CARE; PILOT PROJECTS; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; TAMOXIFEN;

EID: 0033971661     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(99)00510-5     Document Type: Article

References (25)

1. Canney P.A., Hatton M.Q.F. The prevalence of menopausal symptoms in patients treated for breast cancer. Clin Oncol. 6:1994;297-299.
2. Couzi R.J., Helzlsouer K.J., Fetting J.H. Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol. 13:1995;2737-2744.
3. Carpenter J.S., Andylowski M.A., Cordova M., Cunningham L., Studts J., McGrath P., et al. Hot flushes in postmenopausal women treated for breast cancer. 82:1998;1682-1691.
4. Stoll B.A. Hormone replacement therapy in women treated for breast cancer. Eur J Cancer Clin Oncol. 25:1989;1909-1913.
5. Wile A.G., Opfell R.W., Margileth D.A. Hormone replacement therapy in previously treated breast cancer patients. Am J Surg. 165:1993;372-375.
6. DiSaia P.J., Odicino F., Grosen E.A., Cowan B., Pecorelli S., Wile A.G., et al. Hormone replacement therapy in breast cancer. Lancet. 342:1993;1232.
7. Powles T.J., Casey S., O’Brien M., Hickish T. Hormone replacement after breast cancer. Lancet. 342:1992;60.
8. Bluming AZ, Wile AG, Schain W, Dosik GM, Terpenning M, Van-Scoy-Moscher M, et al. Hormone replacement therapy in women with previously treated primary breast cancer (abstract A137). Proceedings of the Annual Meeting of American Society Clinical Oncology 1994:13.
9. Eden J.A., Bush T., Nand S., Wren B.G. A case-controlled study of combined continuous estrogen replacement therapy amongst women with a personal history of breast cancer. Menopause. 2:1995;67-72.
10. Peters GN, Jones SE. Estrogen replacement therapy in breast cancer patients: a time for change (abstract A148). Proceedings of the Annual Meeting of American Society Clinical Oncology 1996:15.
11. Vassilopoulou-Sellin R., Zolinski C. Estrogen replacement therapy in women with breast cancer a survey of patient attitudes. Am J Med Sci. 304:1992;145-149.
12. Vassilopoulou-Sellin R., Klein M.J. Estrogen replacement therapy after treatment for localized breast carcinoma, patient responses and opinions. Cancer. 78:1996;1043-1048.
13. Hunter M.S., Liao K. A psychological analysis of menopausal hot flushes. Br J Clin Psychol. 34:1995;589-589.
14. Aaronson N.K., Ahmedzai S., Bergman B., Bullinger M., Cull A., Duez N.T., et al. The European Organisation for Research and Treatment of Cancer QLQ-C30 a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 85:1993;365-376.
15. Nachtigall L.E. Enhancing patient compliance with hormone replacement therapy at menopause. Obstet Gynaecol. 75:(Suppl 4):1990;77S-80S.
16. Ganz PA, Greendale G, Kahn B, O’Leary JF. Are breast cancer survivors willing to take hormone replacement therapy (HRT) (abstract A102). Proceedings of the Annual Meeting of Society Clinical Oncology 1996:15.
17. Slevin M., Bowling A., Leonard R., Steward W., Harper P., McIllurray M., et al. Volunteers or victims patients’ views of randomised cancer clinical trials. Br J Cancer. 71:1995;1270-1274.
18. Okon M.A., Lee S., Li T.C. Period-free hormone replacement therapy. J Br Menopause Soc. 3:1997;11-14.
19. Meredith C., Symonds P., Webster L., Lamont D., Pyper E., Gillis C.R., et al. Information needs of cancer patients in West Scotland cross-sectional survey of patients’ views. BMJ. 313:1997;724-726.
20. Powles T.J., Jones A.L., Ashley S.E., et al. The Royal Marsden Hospital chemoprevention trial. Breast Cancer Res Treat. 31:1994;73-82.
21. Fisher B., Costantino J.P., Wickerham L., Redmond C.K., Kavanah M., Cronin W.M., et al. Tamoxifen for prevention of breast cancer report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 90:1998;1371-1388.
22. Love R.R., Cameron L., Connell B.C., Leventhal H. Symptoms associated with tamoxifen treatment in postmenopausal women. Arch Intern Med. 151:1991;1842-1847.
23. Powles T.J., Eeles R., Ashley S., Easton D., Chang J., Dowsett M., et al. Interim analysis of breast cancer in The Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet. 352:1998;98-101.
24. Veronesi U., Maisonneuve P., Costa A., Sacchini V., Maltoni C., Robertson C., et al. Prevention of breast cancer with tamoxifen preliminary findings from the Italian randomised trial among hysterectomised women. Lancet. 352:1998;93-97.
25. Androgens and estrogens in the treatment of disseminated mammary carcinoma retrospective study of 1944 patients. J Am Med Assoc. 172:1960;1271-1283.