Evaluation of heparin immobilized chitosan-PEG microbeads for charcoal encapsulation and endotoxin removal

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 28, Issue 1, 2000, Pages 65-77

  Chandy, Thomas ^a   Rao, Gundu H R ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; BIOCOMPATIBILITY; BIOMATERIALS; BLOOD; CHITIN; ENCAPSULATION; ORGANIC COMPOUNDS; SURFACE TREATMENT; TOXICITY;

ARTIFICIAL LIVER; CHITOSAN; DETOXIFICATION; GLUTARALDEHYDE; HEMOPERFUSION; HEPARIN;

POLYETHYLENE GLYCOLS;

ACTIVATED CARBON; CHITOSAN; ENDOTOXIN; GLUTARALDEHYDE; HEPARIN DERIVATIVE; MACROGOL;

ARTICLE; ARTIFICIAL LIVER; BIOCOMPATIBILITY; DETOXIFICATION; ENCAPSULATION; FLOW RATE; HEMOPERFUSION; NONHUMAN;

EID: 0033971240     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.3109/10731190009119786     Document Type: Article

References (24)

1. Chirito. E, Reiter. B, Lister. C and Chang. T.M.S, Artificial liver: The effect of ACAC microencapsulated charcoal hemoperfusion on fulminant hepatic failure, Artif. Org, 1, 76-83, 1977.
2. Chang .M . S and Malave. N, The development and first clinical use of semipermeable microcapsules (artificial cells) as a compact artificial kidney, Transactions ASAIO, 16, 141-145, 1970.
3. Morley. D and Chang. T.M.S, Effect of membrane thickness of colloidion coated Activated charcoal on adsorption of small and middle molecules, Biomat. Artif. Cells and Artif. Org., 15, 617-632,1987.
4. Xu. C.X, Tang. X.J, Niu. Z and Li. Z.M, Studies of adsorbents for haemoperfusion in artificial liver support: 1. Preparation and in vitro studies of crosslinked agarose beads entrapped activated charcoal (CAAC), Int. J. Of Artif. Org, 4,200-204,1981.
5. Chen. Y.M, TangX.J, Xy.C.X and Li. Z.M, Preparation and performance of cross-linked agar encapsulated activated charcoal (CAAC-III), J. Microencapsulation, 8,327-334,1991.
6. Chandy. T and Sharma. C.P, Preparation and performance of chitosan encapsulated activated charcoal (ACCB) adsorbents for small molecules, J. Microencapsulation, 10,475-486,1993.
7. Nolan. J.P, Endotoxin, reticuloendothelial system function and liver injury, Hepatology, 1,458-462,1981.
8. Bysani. G. K, Shenep. J.L, Hildner. W. K, Stidhan. G. L and Roberson. P.K, Detoxification of plasma containing lipopolysaccharide by adsorption, Crit. Care. Med., 18,67-71,1990.
9. Morrison. D.C and Ryan. J.L, Endotoxins and disease mechanisms, Ann. Rev. Med., 38,417421,1987.
10. Hari. P.R, Chandy. T and Sharma. C.P, Chitosan/calcium alginate beads for oral delivery of insulin, J. Appl. Polym. Sci., 59,1795-1801,1996.
11. Chandy. T, Mooradian. D.L and Rao. G.H.R, Chitosan/polyethylene-glycol-alginate microcapsules for oral delivery of hirudin, J. Appl. Polym. Sci., (in Press).
12. Merril. E.W and Saltzman. E.W, Polyethylene oxide as a biomaterial, J. Am. Soc. Artif. Intern. Org., 6,60-64,1983.
13. Chandy. T and Sharma. C.P, Bioactive molecules immobilized to liposome modified albumin blended chitosan membranes-Antithrombotic and permeability properties, J. Colloid. Interface Sci., 130,331-340,1989.
14. Raphael. S.S, "Lynch's Medical Laboratory Technology", 4th edn (W.B. Saunders, Philadelphia), pp.265-270,1983.
15. Xiang-nan. D, Zhen. N, Guo-Zheng. Z and Zong-ming. L, Effect of activated charcoal on endotoxin adsorption. Part:1. An in vitro study, Biomat. Artif. Cells. Artif. Org., 15,229-235,1987.
16. Bang. F.B, A bacterial disease of Limulus Polyphemus, Bull. Johns Hopkins. Hosp., 98,325,1956.
17. Levin. J, and Bang. F.B, Clottable protein in Limulus: Its localization and kinetics of its coagulation by endotoxin, Thromb. Diath. Haemmorr., 19,186-189,1968.
18. Reinhold. R and Fine. J, A technique for quantitative measurement of endotoxin in human plasma. Proc. Soc. Exp. Biol. Med., 137,334-340,1971.
19. Tijssen,. J, Bantjes. A, Van Doorn. A.W.J, Feijen. J, Van Dijk. B, Vonk. C.R and Dijkhuis. I.C, A hemoperfusion column based on activated carbon granules coated with an ultrathin membranes of cellulose acetate, Artif. Org., 3,11-14,1979.
20. Hasirci.. N and Akovali. G, Polymer coating for hemoperfusion over activated charcoal, J. Biomed. Mat. Res, 20, 963-970,1986.
21. Maeda. K, Saito. A, Hawaguchi. S, Sezaki. R, Niwa. T, Naotsuka. M, Kobayashi. K, Asada. H, Yamanoto. Y and Ohta. K, Problems with activated chacoal and alumina as sorbents for medical use, Artif. Org, 3,336-340,1979.
22. Wilkinson. S.P, Endotoxin and liver disease, Scand. J. Gastroenterol, 12,385-386,1977.
23. Chandy. T and Sharma. C.P, Chitosan Matrix for oral sustained delivery of ampicillin, Biomaterials, 14,939-944,1993.
24. Desai. N.P, Hossainy. S.F.A and Hubbell. J.A, Surface immobilized polyethylene oxide for bacterial repellance, Biomaterials, 13,413-420,1992.