Differential regulation of mammalian brain-specific proline transporter by calcium and calcium-dependent protein kinases

British Journal of Pharmacology

Volumn 129, Issue 3, 2000, Pages 465-470

  Jayanthi, Lankupalle D ^a   Wilson, Jennifer J ^a   Montalvo, Jocelyn ^b   DeFelice, Louis J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Chemistry   (United States)

Author keywords

Calcium; CaMK II; Current; PKC; Proline; Proline transporter; Regulation; Uptake

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); BISINDOLYLMALEIMIDE; BRAIN SPECIFIC PROLINE TRANSPORTER; CALCIUM ION; CARRIER PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROLINE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; THAPSIGARGIN; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MEMBRANE CURRENT; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

EID: 0033970480     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703071     Document Type: Article

References (31)

1. Apparsundaram, S., Galli, A., Defelice, L.J., Hartzell, C.H. & Blakely, R.D. (1998a). Acute regulation of norepinephrine transport: I. PKC-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells. J. Pharmacol. Exp. Ther., 287, 733-743.
2. Apparsundaram, S., Giovanetti, E., Schroeter, S. & Blakely, R.D. (1998b). Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. J. Pharmacol. Exp. Ther., 287, 744-751.
3. Casabona, G. (1997). Intracellular signal modulation: a pivotal role for protein kinase C. Prog. Neuro-Psychopharmacol. Biol. Psychiat., 21, 401-425.
4. Cherkin, A., Ickardt, M.J. & Gerbrandt, L.K. (1976). Memory: proline induces retrograde amnesia in chicks. Science, 193, 242-244.
5. Christensen, H.N. (1990). Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev., 70, 43-77.
6. Crump, F.T., Craig, A.M., Kwatra, M. & Fremeau Jr. R.T. (1997). Brain-specific high affinity L-proline transporter: preferential localization to a subset of excitatory nerve terminals incultured rat hippocampal neurons. Soc. Neurosci. Abstr., 23, 134.
7. Fremeau Jr. R.T., Caron, M.G. & Blakely, R.D. (1992). Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain. Neuron, 8, 915-926.
8. Fremeau Jr. R.T., Velaz-Faircloth, M., Miller, J.W., Henzi, V.A., Cohen, S.M., Nadler, J.V., Shafqat, S., Blakely, R.D. & Domin, B. (1996). A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter. Mol. Pharmacol., 49, 1033-1041.
9. Galli, A., Blakely, R.D. & Defelice, L.J. (1996). Norepinephrine transporters have channel modes of conduction. Proc. Natl. Acad. Sci. U.S.A., 93, 8671-8676.
10. Galli, A., Blakely, R.D. & Defelice, L.J. (1998). Patch-clamp and amperometric recordings from norepinephrine transporters: Channel activity and voltage-dependent uptake. Proc. Natl. Acad. Sci. U.S.A., 95, 13260-13265.
11. Galli, A., Defelice, L.J., Duke, B.J., Moore, K.R. & Blakely, R.D. (1995). Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J. Exp. Biol., 198, 2197-2212.
12. Galli, A., Jayanthi, L.D., Ramsey, S., Miller, J.W., Fremeau, R.T. & Defelice, L.J. (1999). Proline and pipecolic acid induce des-tyrosyl enkephalin-sensitive currents in HEK-293 cells transfected with the rat proline transporter. J. Neurosci., 19, 6290-6297.
13. Galli, A., Petersen, C.I., Deblaquiere, M., Blakely, R.D. & Defelice, L.J. (1997). Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J. Neurosci., 17, 3401-3411.
14. Jayanthi, L.D., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H. & Ganapathy, V. (1994). Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J. Biol. Chem., 269, 14424-14429.
15. Kleven, D., Malone, D., Jayanthi, L.D., Magnuson, M., Nadler, J.V., Blakely, R.D. & Fremeau Jr. R.T. (1997). Disruption of the murine high affinity L-proline transporter gene (PROT) by homologous recombination. Soc. Neurosci. Abstr., 23, 982.
16. Merrit, J.E. & Rink, J.T. (1987). Rapid increase in cytosolic free calcium in response to muscarinic stimulation of rat parotid acinar cells. J. Biol. Chem., 262, 4958-4960.
17. Nadler, J.V., Bray, S.D. & Evenson, D.A. (1992). Autoradiographic localization of proline uptake in excitatory hippocampal pathways. Hippocampus, 2, 269-278.
18. Nadler, J.V., Wang, A. & Hakim, A. (1988). Toxicity of L-proline toward rat hippocampal neurons. Brain Res., 456, 168-172.
19. Nashizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607-613.
20. Petersen, C.I. & Defelice, L.J. (1999). Ionic interactions in the drosophila serotonin transporter identify it as a serotonin channel. Nature Neurosci., 2, 605-610.
21. Phang, J.M. & Scriver, C.R. (1989). Disorders of proline and hydroxyproline metabolism. In: C.R. Scriver, A.L. Beaudet, W.S. Shy, and D. Valle, (eds). The Metabolic Basis of Inherited Disease. McGraw-Hill, New York, pp. 577-597.
22. Qian, Y., Galli, A., Ramamoorthy, S., Risso, S., Defelice, L.J. & Blakely, R.D. (1997). Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J. Neurosci., 17, 45-57.
23. Ramamoorthy, J.D., Ramamoorthy, S., Papapetropoulos, A., Catravas, J.D., Leibach, F.H. & Ganapathy, V. (1995). Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporin in choriocarcinoma cells. J. Biol. Chem., 270, 17189-17195.
24. Ramamoorthy, S., Giovanetti, E., Qian, Y. & Blakely, R.D. (1998). Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. J. Biol. Chem., 273, 2458-2466.
25. Renick, S.E., Kleven, D.T., Chan, J., Stenius, K., Milner, T.A., Pickel, V.M. & Fremeau Jr. R.T. (1999). The mammalian brain high-affinity L-proline transporter is enriched preferentially in synaptic vesicles in a subpopulation of excitatory nerve terminals in rat forebrain. J. Neurosci., 19, 21-33.
26. Shafqat, S., Velaz-Faircloth, M., Guadano-Ferraz, A. & Fremeau Jr. R.T. (1993). Molecular characterization of neurotransmitter transporters. Mol. Endocrinol., 7, 1517-1529.
27. Shafqat, S., Velaz-Faircloth, M., Henzi, V.A., Whitney, K.D., Yang-Feng, T.L., Seldin, M.F. & Fremeau Jr. R.T. (1995). Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes. Mol. Pharmacol., 48, 219-229.
28. Stevens, B.R., Kaunitz, J.D. & Wright, E.M. (1984). Intestinal transport of amino acids and sugars: advances using membrane vesicles. Annu. Rev. Physiol., 46, 417-433.
29. Tchoumkeu-Nzouessa, G.C. & Rebel, G. (1996). Regulation of taurine transport in rat astrocytes by protein kinase C: role of calcium and calmodulin. Am. J. Physiol., 270, C1022-C1028.
30. Velaz-Faircloth, M., Guadano-Ferraz, A., Henzi, V.A. & Fremeau Jr. R.T. (1995). Mammalian brain-specific L-proline transporter: neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. J. Biol. Chem., 270, 15755-15761.
31. 2+ -dependent protein kinases modulate proline transport across the renal brush-border membrane. Am. J. Physiol., 268, F155-F162.