Altered redox state of platelet coenzyme Q10 in Parkinson's disease

Journal of Neural Transmission

Volumn 107, Issue 1, 2000, Pages 41-48

  Gotz M E ^a   Gerstner, A ^b   Harth, R ^d   Dirr, A ^d   Janetzky, B ^c   Kuhn, W ^b   Riederer, P ^d   Gerlach, M ^d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d NONE

Author keywords

Coenzyme Q10; Human platelets; L DOPA; Monoamine oxidase B; Oxidative stress; Parkinson's disease; Selegiline

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; HYDROGEN PEROXIDE; LEVODOPA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SELEGILINE; SUPEROXIDE; THROMBOCYTE ENZYME; UBIDECARENONE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON TRANSPORT; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0033969735     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050003     Document Type: Article

References (20)

1. 10 in free radical production and antioxidation. Free Radic Biol Med 8: 545-565
2. Boullin D, O'Brien R (1970) Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-dopa. Br J Pharmacol 39: 779-788
3. Crane FL (1990) Development of concepts for the role of ubiquinones in biological membranes. In: Lenaz G, Barnabei O, Rabbi A, Battino M (eds) Highlights in ubíquinone research. Taylor & Francis, London, pp 3-17
4. Ernster L, Forsmark P, Nordenbrand K (1992) The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles. BioFactors 3: 241-248
5. Götz ME, Dirr A, Burger R, Janetzky B, Weinmüller M, Chan WW, Chen SC, Reichmann H, Rausch W-D, Riederer P (1994) Effect of lipoic acid on redox state of coenzyme Q in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate. Eur J Pharmacol-Mol Pharmacol Sect 266: 291-300
6. 10 in Parkinson's disease. Mov Disord 11 [Suppl 1]: 127
7. Haas RH, Nasirian F, Nakano K, Ward D, Pay M, Hill R, Shults CW (1995) Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol 37: 714-722
8. Jiménez-Jiménez FJ, Molina JA, Fernández-Calle P, Vázquez A, Cabrera-Valdivia F, Catalán MJ, García-Albea E, Bermejo F, Codoceo R (1993) Serum levels of β-carotene and other carotenoids in Parkinon's disease. Neurosci Lett 157: 103-106
9. Koide Y, Koide N, Ross S, Sääf J, Wetterberg L (1981) Monoamine oxidase in human platelets. Kinetics and methodological aspects. Biochem Pharmacol 30: 2893-2900
10. Krige D, Carroll MT, Cooper JM, Marsden CD, Schapira AHV (1992) Platelet mitochondrial function in Parkinson's disease. Ann Neurol 32: 782-788
11. Lang AET, Fahn S (1989) Assessment of Parkinson's disease. In: Munsat TL (ed) Quantification of neurologic deficit. Butterworths, Boston, pp 285-309
12. Reichmann H, Riederer P (1989) Biochemical analyses of respiratory chain enzymes in different brain regions of patients with Parkinson's disease. BMFT Symposium "Morbus Parkinson und andere Basalganglienerkrankungen", Bad Kissingen, p 44 (Abstract)
13. Reichmann H, Lestienne P, Jellinger K, Riederer P (1993) Parkinson's disease and the electron transport chain in postmortem brain. In: Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds) Parkinson's disease: from basic research to treatment. Raven Press, New York, pp 297-299 (Adv Neurol 60)
14. Schapira AHV (1994) Evidence for mitochondrial dysfunction in Parkinson's disease - a critical appraisal. Mov Disord 9: 125-138
15. Sheehan JP, Swerdlow RH, Parker WD, Miller SW, Davis RE, Tuttle JB (1997) Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem 68: 1221-1233
16. 10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 42: 261-264
17. Takahashi T, Okamoto T, Mori K, Sayo H, Kishi T (1993) Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids 28: 803-809
18. Takahashi T, Yamaguchi T, Shitashige M, Okamoto T, Kishi T (1995) Reduction of ubiquinone in membrane lipids by rat liver cytosol and its involvement in the cellular defence system against lipid peroxidation. Biochem J 309: 883-890
19. Tipton KF, Singer TP (1993) The biochemical assay for monoamine oxidase activity. Problems and pitfalls. Biochem Pharmacol 46: 1311-1316
20. + toxicity by deprenyl (selegiline). Ann NY Acad Sci 738: 214-221