Acquisition of chloramphenicol resistance by the linearization and integration of the entire staphylococcal plasmid pC194 into the chromosome of Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 2, 2000, Pages 393-395

  Widdowson, Carol A ^a   Adrian, Peter V ^a   Klugman, Keith P ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CHLORAMPHENICOL ACETYLTRANSFERASE; CLINDAMYCIN; ERYTHROMYCIN; PENICILLIN G; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CONTROLLED STUDY; DNA REPLICATION ORIGIN; GENE INSERTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; STREPTOCOCCUS PNEUMONIAE;

BASE SEQUENCE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHLORAMPHENICOL RESISTANCE; CHROMOSOMES, BACTERIAL; DNA, BACTERIAL; HUMANS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; REPLICATION ORIGIN; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE;

EID: 0033969285     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.2.393-395.2000     Document Type: Article

References (18)

1. Ayoubi, P., A. O. Kiliç, and M. N. Vijayakumar. 1991. Tn5253, the pneumococcal Ω(cat tet) BM6001 element, is a composite structure of two conjugative transposons, Tn5251 and Tn5252. J. Bacteriol. 173:1617-1622.
2. Ballester, S., P. Lopez, J. C. Alonso, M. Espinosa, and S. A. Lacks. 1986. Selective advantage of deletions enhancing chloramphenicol acetyltransferase gene expression in Streptococcus pneumoniae plasmids. Gene 41:153-163.
3. Ballester, S., P. Lopez, M. Espinosa, J. C. Alonso, and S. A. Lacks. 1989. Plasmid structural instability associated with pC194 replication functions. J. Bacteriol. 171:2271-2277.
4. Dang-Van, A., G. Tiraby, J. F. Acar, W. V. Shaw, and D. H. Bonanchaud. 1978. Chloramphenicol resistance in Streptococcus pneumoniae: enzymatic acetylation and possible ptasmid linkage. Antimicrob. Agents Chemother. 13:557-583.
5. David, F., G. de Céspèdes, F. Delbos, and T. Horaud. 1993. Diversity of chromosomal genetic elements and gene identification in antibiotic-resistant strains of Streptococcus pneumoniae and Streptococcus bovis. Plasmid 29:147-153.
6. Gennaro, M. L., J. Kornblum, and R. P. Novick. 1987. A site-specific recombination function in Staphylococcus aureus plasmids. 196:2601-2610.
7. Gruss, A., and S. D. Ehrlich. 1989. The family of highly interrelated single-stranded deoxyribonucleic acid plasmids. Microbiol. Rev. 53:231-241.
8. Horinouchi, S., and B. Weisblum. 1982. Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance. J. Bacteriol. 150:815-825.
9. Lefevre, J. C., G. Faucon, A. M. Sicard, and A. M. Gasc. 1993. DNA fingerprinting of Streptococcus pneumoniae by pulsed-field gel electrophoresis. J. Clin. Microbiol. 31:2724-2728.
10. Michel, B., and S. D. Ehrlich. 1986. Illegitimate recombination occurs between the replication origin of plasmid pC194 and a progressing replication fork. EMBO J. 5:3691-3696.
11. Miyamura, S., H. Ochiai, Y. Nitahara, Y. Nakagawa, and M. Tereo. 1977. Resistance mechanism of chloramphenicol in Streptococcus haemolyticus, Streptococcus pneumoniae and Streptococcus faecalis. Microbiol. Immunol. 21:69-76.
12. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 4th ed. Approved standard M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
13. Peeters, B. P., J. H. de Boer, S. Bron, and G. Venema. 1988. Structural plasmid instability in Bacillus subtilis: effect of direct and inverted repeats. Mol. Gen. Genet. 212:450-458.
14. Pepper, K., G. de Céspèdes, and T. Horaud. 1988. Heterogeneity of chromosomal genes encoding chloramphenicol resistance in streptococci. Plasmid 19:71-74.
15. te Riele, H., B. Michel, and S. D. Ehrlich. 1986a. Are single-stranded circles intermediates in plasmid DNA replication? EMBO J. 5:631-637.
16. te Riele, H., B. Michel, and S. D. Ehrlich. 1986b. Single-stranded plasmid DNA in Bacillus subtilis and Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 83:2541-2545.
17. Vijayakumar, M. N., and S. Ayalew. 1993. Nucleotide sequence analysis of the termini and chromosomal locus involved in site-specific integration of the streptococcal conjugative transposon Tn5252. J. Bacteriol. 175:2713-2719.
18. Vijayakumar, M. N., S. D. Priebe, and W. R. Guild. 1986. Structure of a conjugative element in Streptococcus pneumoniae. J. Bacteriol. 166:978-984.