Enhancement by escins Ib and IIb of Mg2+ absorption from digestive tract in mice: Role of nitric oxide

European Journal of Pharmacology

Volumn 387, Issue 3, 2000, Pages 337-342

  Li, Yuhao ^a   Matsuda, Hisashi ^a   Wen, Suping ^a   Yamahara, Johji ^a   Yoshikawa, Masayuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Escin Ib; Escin IIb; Mg2+ absorption; Nitric oxide (NO)

Indexed keywords

ARGININE; DEXAMETHASONE; ESCIN; MAGNESIUM SULFATE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DIGESTIVE SYSTEM; DOSE RESPONSE; ENANTIOMER; ENZYME INHIBITION; GASTROINTESTINAL ABSORPTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARGININE; DEXAMETHASONE; ESCIN; INTESTINAL ABSORPTION; MAGNESIUM; MALE; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE;

EID: 0033968751     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00772-4     Document Type: Article

References (35)

1. Ahsan S.K. Metabolism of magnesium in health and disease. J. Indian Med. Assoc. 95:1997;507-510.
2. Barry M.K., Aloisi J.D., Pickering S.P., Yeo C.J. Nitric oxide modulates water and electrolyte transport in the ileum. Ann. Surg. 219:1994;382-388.
3. Bredt D.S., Hwang P.M., Synder S.H. Localization of nitric oxide synthase indicating a neuronal role for nitric oxide. Nature. 347:1990;768-770.
4. Brookes S.J.H. Neuronal nitric oxide in the gut. J. Gastroenterol. Hepatol. 8:1993;590-603.
5. Elin R.J. Magnesium metabolism in health and disease. Dis.-Mon. 34:1988;161-218.
6. Gaginella T.S., Mascolo N., Izzo A.A., Autore G., Capasso F. Nitric oxide as a mediator of bisacodyl and phenolphthalein laxative action: induction of nitric oxide synthase. J. Pharmacol. Exp. Ther. 270:1994;1239-1245.
7. Garland H.O. New experimental data on the relationship between diabetes mellitus and magnesium. Magnesium Res. 5:1992;193-202.
8. Garthwaite J. Glutamate, nitric oxide and cell-cell signaling in the nervous system. Trends Neurosci. 14:1991;60-67.
9. Hällgren A.G., Flemström G., Sababi M., Nylander O. Effects of nitric oxide inhibition on duodenal function in rat: involvement of neural mechanisms. Am. J. Physiol. 269:1995;G246-G254.
10. Hoffman R.A., Zhang G.S., Nussler N.C., Glixner S.L., Ford H.R., Simmons R.L., Watkins S.C. Constitutive expression of inducible nitric oxide synthase in the mouse ilea mucosa. Am. J. Physiol. 272:1997;G383-G392.
11. Izzo A.A., Gaginella T.S., Mascolo N., Capasso F. Nitric oxide as a modulator of the laxative action of magnesium sulphate. Br. J. Pharmacol. 113:1994;228-232.
12. Izzo A.A., Mascolo N., Capasso F. Nitric oxide as a modulator of intestinal water and electrolyte transport. Dig. Dis. Sci. 43:1998;1605-1620.
13. Lamas S., Marsden P.A., Li G.K., Tempst P., Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. U.S.A. 89:1992;6348-6352.
14. Maher M.M., Gontarek J., Jimenez R.E., Cahill P.A., Yeo C.J. Endogenous nitric oxide promotes ileal absorption. J. Surg. Res. 58:1995;687-692.
15. G-nitro-L-arginine on blood flow and water fluxes in rat ileum. Br. J. Pharmacol. 112:1994;304-310.
16. Mascolo N., Izzo A.A., Barbato F., Capasso F. Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhea in the rat. Br. J. Pharmacol. 108:1993;861-864.
17. Matsuda H., Murakami T., Li Y., Yamahara J., Yoshikawa M. Mode of action of escins Ia and IIa and E,Z-senegin II on glucose absorption in gastrointestinal tract. Bioorg. Med. Chem. 6:1998;1019-1023.
18. Matsuda H., Li Y., Murakami T., Yamahara J., Yoshikawa M. Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastric emptying in mice. Eur. J. Pharmacol. 368:1999;237-243.
19. Matsuda H., Li Y., Yoshikawa M. Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastrointestinal transit and ileus in mice. Bioorg. Med. Chem. 7:1999;1737-1741.
20. Matsuda H., Li Y., Yoshikawa M. Roles of endogenous prostaglandins and nitric oxide in inhibitions of gastric emptying and accelerations of gastrointestinal transit by escins Ia, Ib, IIa, and IIb in mice. Life Sci. 66:1999;PL41-46.
21. Matsuda H., Li Y., Yoshikawa M. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur. J. Pharmacol. 373:1999;63-70.
22. McNaughton W.K. Nitric oxide-donating compounds stimulate electrolyte transport in the guinea-pig intestine in vitro. Life Sci. 53:1993;585-593.
23. Miller M.J.S., Gaginella T.S. Nitric oxide as a mediator of intestinal mucosal function. Gaginella T.S. Regulatory Mechanisms in Gastrointestinal function. 1995;199-218 CRC Press, Boca Raton.
24. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysilogy and pharmacology. Pharmacol. Rev. 43:1991;109-142.
25. Murray J., Du C., Ledlow A., Bates J.N., Conklin J.L. Nitric oxide: mediator of nonadrenergic noncholinergic responses of opossum esophageal muscle. Am. J. Physiol. 261:1991;G401-G406.
26. Palmer R.M.J., Ashton D.S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (London). 333:1988;664-666.
27. Radomski M.W., Palmer R.M.J., Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87:1990;10043-10047.
28. Rao R.K., Riviere P.J.M., Pascaud X., Junien J.L., Porreca F. Tonic regulation of mouse ileal ion transport by nitric oxide. J. Pharmacol. Exp. Ther. 269:1994;626-631.
29. Rees D.D., Palmer R.M.J., Schultz R., Hodson H.F., Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br. J. Pharmacol. 101:1990;746-752.
30. Schirgi-Degen A., Beubler E. Significance of nitric oxide in the stimulation of intestinal fluid absorption in the rat jejunum in vivo. Br. J. Pharmacol. 114:1995;13-18.
31. Spiller R.C. Intestinal absorptive function. Gut. 35:1994;S5-S9.
32. Whittle B.J.R. Nitric oxide in gastrointestinal physiology and pathology. Johnson L.R. Physiology of the Gastrointestinal Tract. 3rd edn. 1994;267-294 Raven Press, New York.
33. Wilson K.T., Xie Y., Musch M.W., Chang E.B. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J. Pharmacol. Exp. Ther. 266:1993;224-230.
34. Yoshikawa M., Harada E., Murakami T., Matsuda H., Wariishi N., Yamahara J., Murakami N., Kitagawa I. Escins Ia, Ib, IIa, IIb, and IIIa, bioactive triterpene oligoglycosides from the seeds of Aesculus hippocastanum L.: their inhibitory effects on ethanol absorption and hypoglycemic activity on glucose tolerance test. Chem. Pharm. Bull. 42:1994;1357-1359.
35. Yoshikawa M., Murakami T., Matsuda H., Yamahara J., Murakami N., Kitagawa I. Bioactive saponins and glycosides. III. Horse chestnut. (1): the structures, inhibitory effects on ethanol absorption, and hypoglycemic activity of escins Ia, Ib, IIa, IIb, and IIIa from the seeds of Aesculus hippocastanum L. Chem. Pharm. Bull. 44:1996;1454-1464.