Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic patients

Clinical and Experimental Allergy

Volumn 30, Issue 1, 2000, Pages 56-63

  Taylor, D A ^a   Harris, J G ^a   O'Connor, B J ^a,b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Asthma; Bolus dose challenge; Incremental dose challenge; Inhaled allergen challenge; Validity

Indexed keywords

ALLERGEN;

ADULT; ALLERGY; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION TEST; MALE; PRIORITY JOURNAL; PROVOCATION TEST;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; ALLERGENS; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOSPIROMETRY; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG ADMINISTRATION SCHEDULE; FORCED EXPIRATORY VOLUME; HUMANS; INTRADERMAL TESTS; MALE; NEBULIZERS AND VAPORIZERS; TIME FACTORS;

EID: 0033968385     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00657.x     Document Type: Article

References (28)

1. 1 O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987; 136:740-51.
2. 2 Melillo G, Aas K, Davies RJ et al. Guidelines for the standardization of bronchial provocation tests with allergens. Allergy 1991; 46:321-9.
3. 3 Sterk PJ, Fabbri LM, Quanjer PH et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993; 6:53-83.
4. 4 Chai H, Farr RS, Froehich LA et al. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975; 56:323-7.
5. 5 Killian D, Cockcroft DW, Hargreave FE, Dolovich J. Factors in allergen-induced asthma: relevance of the intensity of the airways allergic reaction and non-specific reactivity. Clin Allergy 1976; 6:219-25.
6. 6 Cockcroft DW, Murdock KY, Kirby J, Hargreave FE. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am Rev Respir Dis 1987; 135:264-7.
7. 7 Pavord ID, Wong CS, Williams J, Tattersfield AE. Effect of inhaled prostaglandin E2 on allergen-induced asthma. Am Rev Respir Dis 1993; 148:87-90.
8. 8 Twentyman OP, Finnerty JP, Holgate ST. The inhibitory effect of nebulised albuterol on the early and late asthmatic reactions and increase in airway responsiveness provoked by inhaled allergen in asthma. Am Rev Respir Dis 1991; 144:782-7.
9. 9 Kopferschmitt-Kubler MC, Bigot H, Pauli G. Allergen bronchial challenge tests: Variability and reproducibility of the early response. J Allergy Clin Immunol 1987; 80:730-40.
10. 10 Bianco S, Pieroni MG, Refini RM, Rottoli L, Sestini P. Protective effect of inhaled furosemide on allergen induced early and late asthmatic reactions. N Engl J Med 1989; 321:1069-73.
11. 11 Pelikan Z, Knottnerus I. Inhibition of the late asthmatic response by nedocromil sodium administered more than two hours after allergen challenge. J Allergy Clin Immunol 1993; 92:19-28.
12. 12 O'Shaughnessy KM, Taylor IK, O'Connor BJ, O'Connell F, Thomson H, Dollery CT. Potent leukotriene D4 receptor antagonist ICI 204, 219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction. Am Rev Respir Dis 1993; 147:1431-5.
13. 13 Booij-Noord H, De Vries K, Sluiter HJ, Orie NGM. Late bronchial obstructive reaction to experimental inhalation of house dust extract. Clin Allergy 1972; 2:43-61.
14. 14 Robertson DG, Kerigan AT, Hargreave FE, Dolovich J. Late asthmatic responses induced by ragweed pollen allergen. J Allergy Clin Immunol 1974; 54:244-54.
15. 15 Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151:1894-9.
16. 16 Fahy JV, Liu J, Wong H, Boushey HA. Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation. J Allergy Clin Immunol 1994; 93:1031-9.
17. 17 Manning PJ, Stevens WH, Cockcroft DW, O'Byrne PM. The role of thromboxane in allergen-induced asthmatic responses. Eur Respir J 1991; 4:667-72.
18. 18 Bel EH, Timmers MC, Dijkman JH, Stahl EG, Sterk PJ. The effect of an inhaled leukotriene antagonist, L-648,051, on early and late asthmatic reactions and subsequent increase in airway responsiveness in man. J Allergy Clin Immunol 1990; 85:1067-75.
19. 19 Freitag A, Watson RM, Eastwood C, O'Byrne PM. Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. Thorax 1993; 48:594-8.
20. 20 Cockcroft DW, McParland CP, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993; 342:833-7.
21. 21 Ward AJM, Mckenniff M, Evans JM, Page CP, Costello JF. Theophylline - an immunomodulatory role in asthma? Am Rev Respir Dis 1993; 147:518-23.
22. 22 Cockcroft DW, Murdock KY. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J Allergy Clin Immunol 1987; 79:734-40.
23. 23 Inman MD, Watson RM, Cockcroft DW, Wong BJO, Hargreave FE, O'Byrne PM. Reproducibility of allergen-induced early and late asthmatic responses. J Allergy Clin Immunol 1995; 95:1191-5.
24. 24 Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991; 337:690-4.
25. 25 Evans DJ, Barnes PJ, Spaethe SM, van Alstyne EL, Mitchell MI, O'Connor BJ. Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma. Thorax 1996; 51:1178-84.
26. 26 Taylor DA, McGrath JL, O'Connor BJ, Barnes PJ. Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide. Am J Respir Crit Care Med 1998; 158:99-106.
27. 27 Chin S. Repeatability and method comparison. Thorax 1991; 46:454-6.
28. 28 Frolund L, Madsen F, Scharling B, Heinig JH, Gemer Svendsen U. Bronchial allergen challenge: dose versus concentration. Clin Exp Allergy 1992; 22:219-25.