TMC-86A, B and TMC-96, new proteasome inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. II. Physico-chemical properties and structure determination

Journal of Antibiotics

Volumn 53, Issue 1, 2000, Pages 63-65

  Koguchi, Yutaka ^a   Kohno, Jun ^a   Suzuki, Shin Ichi ^a   Nishio, Maki ^a   Takahashi, Kohei ^a   Ohnuki, Tetsuo ^a   Komatsubara, Saburo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PROTEASOME INHIBITOR; TMC 86A; TMC 86B; TMC 96; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

SACCHAROTHRIX; STREPTOMYCES;

EID: 0033967216     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.63     Document Type: Article

References (3)

1. KOGUCHI, Y.; J. KOHNO, S. SUZUKI, M. NISHIO, K. TAKAHASHI, T. OHNUKI & S. KOMATSUBARA: TMC-86A, B and TMC-96, new proteasome inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. I. Taxonomy, fermentation, isolation, and biological activities. J. Antibiotics 52: 1069-1076, 1999
2. SUGAWARA, K.; M. HATORI, Y. NISHIYAMA, K. TOMITA, H. KAMEI, M. KONISHI & T. OKI: Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity. J. Antibiotics 43:8-18, 1990
3. HOSHI, H.; T. OHNUMA, S. ABURAKI, M. KONISHI & T. OKI: A total synthesis of 6,7-dihydroeponemycin and determination of stereochemistry of the epoxide ring. Tetrahedron Lett. 34: 1047-1050, 1993