Ciprofloxacin-warfarin coagulopathy: A case series

American Journal of Hematology

Volumn 63, Issue 1, 2000, Pages 28-31

  Ellis, Robert J ^a   Mayo, Matthew S ^a   Bodensteiner, David M ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Bleeding; Ciprofloxacin; Coagulopathy; Drug drug interaction; Prothrombin time; Warfarin

Indexed keywords

CIPROFLOXACIN; CYCLOSPORIN; DILTIAZEM; ESTROGEN; FOLIC ACID; LISINOPRIL; METHOTREXATE; PREDNISONE; WARFARIN;

ADULT; AGE; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; CASE REPORT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; POLYPHARMACY; PRIORITY JOURNAL; PROTHROMBIN TIME; RHEUMATOID ARTHRITIS; STROKE;

AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; CIPROFLOXACIN; DRUG INTERACTIONS; FEMALE; HUMANS; HYPOPROTHROMBINEMIAS; MALE; MIDDLE AGED; PLASMA; PROTHROMBIN TIME; VITAMIN K; WARFARIN;

EID: 0033966355     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(200001)63:1<28::AID-AJH6>3.0.CO;2-J     Document Type: Article

References (20)

1. Dugonni-Kramer BM. Ciprofloxacin-warfarin interaction. Drug Intell Clin Pharm 1991;25:1397 (letter).
2. Mott FE, Murphy S, Hunt V. Ciprofloxacin and warfarin. Ann Intern Med 1989;111(6):542-543 (letter).
3. Jolson HM, Tanner LA, Green L, Grasela TH. Adverse reaction reporting of interaction between warfarin and fluoroquinolones. Arch Intern Med 1991;151:1003-1004.
4. Linville D, Emory C, Graves L. Ciprofloxacin and warfarin interaction. Am J Med 1991;90:765 (letter).
5. Renzi R, Finkbeiner S. Ciprofloxacin interaction with sodium warfarin: a potentially dangerous side effect. Am J Emerg Med 1991;9:551-552.
6. Johnson KC, Joe RH, Self TH. Drug interaction. J Fam Pract 1991; 33:338 (letter).
7. Kamada AK. Possible interaction between ciprofloxacin and warfarin. Drug Intell Clin Pharm 1990;24:27 (letter).
8. Rindone JP, Keuy CL, Jones WN, Garewal HS. Hypoprothrombinemic effect of warfarin not influenced by ciprofloxacin. Clin Pharm 1991; 10:136-138.
9. Bianco TM, Bussey HI, Farnett LE, Linn WD, Rousch MK, Wong YW. Potential warfarin-ciprofloxacin interaction in patients receiving long-term anticoagulation. Pharmacotherapy 1992;12:435-439.
10. Israel DS, Stotka J, Rock W, Sintek CD, Kamada AK, Klein C, et al. Effect of ciporofloxacin on the pharmacokineteics and pharmacodynamics of warfarin. Clin Infect Dis 1996;22:251-256.
11. ® to hospital medicine. 1997;10:1-4.
12. Hutchinson TA, Lane DA. Assessing methods tor causality assessment of suspected adverse drug reactions. J Clin Epidemiol 1989;42:5-16.
13. Breckenridge A. Oral anticoagulant drugs: pharmacokinetic aspects. Semin Hematol 1978;15:19-26.
14. Verho M, Malenczyk V, Rosenkranz B, Grotsch H. Absence of interaction between ofloxacin and phenprocoumon. Curr Med Res Opin 1987;10:474-479.
15. Toon S, Hopkins KJ, Garstang FM, Aarons L, Sedman A, Rowland M. Enoxacin-warfarin interaction: pharmacokinetic and sterochemical aspects. Clin Pharmacol Ther 1987;42:33-41.
16. Rocci ML, Vlasses PH, Distlerath LM, Gregg MH, Wheeler SC, Zing W, et al. Norfloxacin does not alter warfarin's disposition or anticoagulant effect. J Clin Pharmacol 1990;30:728-732.
17. Wyld P, Nimmo W, Millar, Coles S, Abbott. The lack of potentiation of the anticoagulant effect of warfarin when administered concurrently with temafloxacin. 17th International Congress of Chemotherapy; June 23-28, 1991; Berlin, Germany (abstract 413a).
18. Sellers EM, Koch-Weser J. Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic and nalidixic acids. Clin Pharmacol Ther 1970;11:524-529.
19. Gillum GJ, Israel DS, Polk RE. Pharmacokinetic drug interactions with antimicrobial agents. Clin Pharmacokinet 1993;25:450-482.
20. Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer DE. Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA 1998;279:657-662.