May the drug transporter P glycoprotein affect the antiviral activity of human immunodeficiency virus type 1 proteinase inhibitors? [multiple letters)

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 2, 2000, Pages 473-474

  Turriziani, Ombretta ^a   Di Marco, Paola ^a   Antonelli, Guido ^a   Dianzani, Ferdinando ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; INDINAVIR; PROTEINASE INHIBITOR; SAQUINAVIR; VERAPAMIL;

ANTIVIRAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LETTER; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION;

BIOLOGICAL TRANSPORT; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED;

EID: 0033966185     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.2.473-474.2000     Document Type: Letter

References (6)

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4. Srinivas, R. V., D. Middlemas, P. Flynn, and a. Fridland. 1998. Human immunodeficiecy cirus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and NRP1 but retain antibiral efficacy in cell lines expressing these transporters. Antimicrob. Agents Chemother. 42:3157-3162.
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