Purification and characterization of an 18-kd allergen of birch (Betula verrucosa) pollen: Identification as a cyclophilin

Journal of Allergy and Clinical Immunology

Volumn 105, Issue 2 II, 2000, Pages 286-291

  Cadot, P ^a,c   Diaz J F ^a   Proost, P ^b   Van Damme, J ^b   Engelborghs, Y ^a   Stevens, E A M ^a   Ceuppens, J L ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Allergen; Birch pollen; Chromatography; Cyclophilin; Peptidyl prolyl isomerase

Indexed keywords

CYCLOPHILIN; POLLEN ANTIGEN;

ARTICLE; HUMAN; ISOELECTRIC FOCUSING; PHYLOGENY; POLLEN ALLERGY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PURIFICATION; SKIN TEST;

BETULA VERRUCOSA;

EID: 0033965967     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(00)90078-2     Document Type: Article

References (38)

1. Valenta R, Niederberger V, Fischer S, Jäger S, Spitzauer S, Kraft D. Tree pollen allergens In: Lockey RF, Bukantz SC, editors. Allergens and allergen immunotherapy. 2nd ed. New York: Marcel Dekker; 1999. p 85-102.
2. Swoboda I, Jilek A, Ferreira F, Engel E, Hoffmann-Sommergruber K, Scheiner O, et al. Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995;270:2607-13.
3. Ipsen H, Løwenstein H. Isolation and immunological characterization of the major allergen of birch pollen (Betula verrucosa). J Allergy Clin Immunol 1983;72:150-9.
4. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, et al. The gene coding for the major birch pollen allergen BetvI, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-8.
5. Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H, et al. Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95:962-9.
6. Fahlbusch B, Rudeschko O, Müller WD, Schlenvoigt G, Vettermann S, Jager L. Purification and characterization of the major allergen from apple and its allergenic cross-reactivity with Bet v1. Int Arch Allergy Immunol 1995;108:119-26.
7. Vanek-Krebitz M, Hoffmann-Sommergruber K, Laimer da Camara Machado M, Susani M, Ebner C, Kraft D, et al. Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Commun 1995;214:538-51.
8. Vieths S, Janek K, Aulepp H, Petersen A. Isolation and characterization of the 18-kDa major apple allergen and comparison with the major birch pollen allergen (Bet v I). Allergy 1995;50:421-30.
9. Valenta R, Duchêne M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, et al. Identification of profilin as a novel pollen allergen: IgE autore-activity in sensitized individuals. Science 1991;253:557-60.
10. Engel E, Richter K, Obermeyer G, Briza P, Kungl AJ, Simon B, et al. Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains. J Biol Chem 1997;272:28630-7.
11. 2+. EMBO J 1994;13:3481-6.
12. Vieths S, Frank E, Scheurer S, Meyer HE, Hrazdina G, Haustein D. Characterization of a new IgE-binding 35-kDa protein from birch pollen with cross-reacting homologues in various plant foods. Scand J Immunol 1998;47:263-72.
13. Cadot P, Lejoly M, Van Hoeyveld EM, Stevens EAM. Influence of the pH of the extraction medium on the composition of birch (Betula verrucosa) pollen extracts. Allergy 1995;50:431-7.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
15. Fischer G, Bang H, Berger E, Schellenberger A. Conformational specificity of chymotrypsin toward proline-containing substrates. Biochim Biophys Acta 1984;791:87-97.
16. Gasser CS, Gunning DA, Budelier KA, Brown SM. Structure and expres sion of cytosolic cyclophilin/peptidyl-prolyl cis-trans isomerase of higher plants and production of active tomato cyclophilin in Escherichia coli. Proc Natl Acad Sci U S A 1990;87:9519-23.
17. Schreiber S. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991;251:283-7.
18. Marks A. Cellular functions of immunophilins. Physiol Rev 1996;76:631-49.
19. Mattoo AK. Peptidylprolyl cis-trans-isomerases from plant organelles. Methods Enzymol 1998;290:84-100.
20. Hayman GT, Miernyk JA. The nucleotide and deduced amino acid sequences of a peptidyl-prolyl cis-trans isomerase from Arabidopsis thaliana. Biochim Biophys Acta 1994;1219:536-8.
21. Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984;226:544-7.
22. Fischer G, Wittmann-Liebold B, Lang K, Kiefhaber T, Schmid FX. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 1989;337:476-8.
23. Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 1989;337:473-5.
24. Breiman A, Fawcett TW, Ghirardi ML, Mattoo AK. Plant organelles contain distinct peptidylprolyl cis-trans isomerases. J Biol Chem 1992;267:21293-6.
25. Lippuner V, Chou IT, Varian Scott S, Ettinger WF, Theg SM, Gasser CS. Cloning and characterization of chloroplast and cytosolic forms of cyclophilin from Arabidopsis thaliana. J Biol Chem 1994;269:7863-8.
26. Sheldon PS, Venis MA. Purification and characterization of cytosolic and microsomal cyclophilins from maize (Zea mays). Biochem J 1996;315:965-9.
27. Chou IT, Gasser CS. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Plant Mol Biol 1997;35:873-92.
28. Luan S, Albers MW, Schreiber SL. Light-regulated, tissue-specific immunophilins in a higher plant. Proc Natl Acad Sci U S A 1994;91:984-8.
29. Freskgard P-O, Bergenhem N, Jonsson B-H, Svensson M, Carlsson U. Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase. Science 1992;258:466-8.
30. Baker EK, Colley NJ, Zuker CS. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J 1994;13:4886-95.
31. Liu J, Farmer J, Lane W, Friedman J, Weissman I, Schreiber S. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991;66:807-15.
32. Marivet J, Margis-Pinheiro M, Frendo P, Burkard G. Bean cyclophilin gene expression during plant development and stress conditions. Plant Mol Biol 1994;26:1181-9.
33. Kullertz G, Liebau A, Rucknagel P, Schierhorn A, Diettrich B, Fischer G, et al. Stress-induced expression of cyclophilins in proembryonic masses of Digitalis lanata does not protect against freezing/thawing stress. Planta 1999;208:599-605.
34. Swoboda I, Scheiner O, Kraft D, Breitenbach M, Heberle-Bors E, Vicente O. A birch gene family encoding pollen allergens and pathogenesis-related proteins. Biochim Biophys Acta 1994;1219:457-64.
35. Homer WE, Reese G, Lehrer SB. Identification of the allergen Psi c 2 from the basidiomycete Psilocibe cubensis as a fungal cyclophilin. Int Arch Allergy Immunol 1995;107:298-300.
36. Crameri R. Epidemiology and molecular basis of the involvement of Aspergillus fumigatus in allergic diseases. In: Brakhage AA, Jahn B, Schmidt A. editors. Contributions in microbiology. Vol 2. Basel: Karger; 1999. p 44-56.
37. Appenzeller U, Meyer C, Menz G, Blaser K, Crameri R. IgE-mediated reactions to autoantigens in allergic diseases. Int Arch Allergy Immunol 1999;118:193-6.
38. Lindborg M, Magnusson CGM, Zargari A, Schmidt M, Scheynius A, Crameri R, et al. Selective cloning of allergens from the skin colonizing yeast Malassezia furfur by phage surface display technology. J Invest Dermatol 1999;113:156-61.