Effect of caffeine on clozapine pharmacokinetics in healthy volunteers

British Journal of Clinical Pharmacology

Volumn 49, Issue 1, 2000, Pages 59-63

  Hägg, Staffan ^a   Spigset, Olav ^a,b   Mjörndal, Tom ^a   Dahlqvist, Rune ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Caffeine; Clozapine; CYP1A2; Drug interaction; Pharmacokinetics

Indexed keywords

CAFFEINE; CLOZAPINE; CLOZAPINE N OXIDE; DRUG METABOLITE; KOFFEIN; NORCLOZAPINE; PARAXANTHINE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIPSYCHOTIC AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; CROSS-OVER STUDIES; HUMANS; MALE; THEOPHYLLINE;

EID: 0033965868     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00111.x     Document Type: Article

References (18)

1. 1 Bertilsson L, Carrillo JA, Dahl ML, et al. Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol 1994; 38: 471-473.
2. 2 Jerling M, Lindstrom L, Bondesson U, Bertilsson L. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 1994; 16: 368-374.
3. 3 Hughes JR, McHugh P, Holtzman S. Caffeine and schizophrenia. Psychiatr Serv 1998; 49: 1415-1417.
4. 4 Winstead DK. Coffee consumption among psychiatric inpatients. Am J Psychiatry 1976; 133: 1447-1450.
5. 5 Odom White A, Leon J. Clozapine levels and caffeine. J Clin Psychiatry 1996; 57: 175-176.
6. 6 Carrillo JA, Herraiz AG, Ramos SI, Benitez J. Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. J Clin Psychopharmacol 1998; 18: 311-316.
7. 7 Chen L, Bondoc FY, Lee MJ, Hussin AH, Thomas PE, Yang CS. Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats. Drug Metab Dispos 1996; 24: 529-533.
8. 8 Ayalogu EO, Snelling J, Lewis DF, Talwar S, Clifford MN, Ioannides C. Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus. Biochim Biophys Acta 1995; 17: 89-94.
9. 9 Spigset O, Granberg K, Hägg S, Söderström E, Dahlqvist R. Non-linear fluvoxamine disposition. Br J Clin Pharmacol 1998; 45: 257-263.
10. 10 Weigmann H, Hiemke C. Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection. J Chromatogr 1992; 583: 209-216.
11. 11 Hägg S, Granberg K, Spigset O, Persbo Lundqvist G, Mjörndal T, Dahlqvist R. Absence of interaction between erythromycin and a single dose of clozapine. Eur J Clin Pharmacol 1999; 55: 221-226.
12. 12 Spigset O, Hägg S, Söderström E, Dahlqvist R. Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance. Eur J Clin Pharmacol 1999; 54: 943-946.
13. 13 Spigset O, Hägg S, Söderström E, Dahlqvist R. The paraxanthine/caffeine ratio in serum or saliva as a measure of CYP1A2 activity: When should the sample be obtained? Pharmacogenetics 1999; 9: 409-412.
14. 14 Kamimori GH, Lugo SI, Penetar DM, et al. Dose-dependent caffeine pharmacokinetics during severe sleep deprivation in humans. Int J Clin Pharmacol Ther 1995; 33: 182-186.
15. 15 Denaro CP, Brown CR, Wilson M, Jacob P 3rd, Benowitz NL. Dose-dependency of caffeine metabolism with repeated dosing. Clin Pharmacol Ther 1990; 48: 277-285.
16. 16 Kaplan GB, Greenblatt DJ, Ehrenberg BL, et al. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol 1997; 37: 693-703.
17. 17 Tang Liu DD, Williams RL, Riegelman S. Disposition of caffeine and its metabolites in man. J Pharmacol Exp Ther 1983; 224: 180-185.
18. 18 Jerling M, Merle Y, Mentre F, Mallet A. Population pharmacokinetics of clozapine evaluated with the nonparametric maximum likelihood method. Br J Clin Pharmacol 1997; 44: 447-453.