TT virus infection in patients with chronic hepatitis C virus infection - Effect of primers, prevalence, and clinical significance

Journal of Hepatology

Volumn 32, Issue 2, 2000, Pages 339-343

  Mizokami, Masashi ^a   Albrecht, Janice K ^b   Kato, Takanobu ^a   Orito, Etsuro ^a   Lai, Vicky C H ^b   Goodman, Zachary ^c   Hong, Zhi ^b   Lau, Johnson Y N ^b  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

HCV; Interferon; Liver disease; PCR; Ribavirin; TTV; Viremia

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; PRIMER DNA; REBETRON; RECOMBINANT ALPHA2B INTERFERON; VIRUS RNA;

ADULT; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; FEMALE; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; TORQUE TENO VIRUS; VIRUS DETECTION; VIRUS INFECTION;

EID: 0033965507     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80081-1     Document Type: Article

References (14)

1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 241:1997;92-97.
2. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, et al. Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res. 10:1998;1-16.
3. Takahashi K, Ohta Y, Mishiro S. Partial ~2.4-kb sequences of TT virus (TTV) genome from eight Japanese isolates: diagnostic and phylogenetic implications. Hepatol Res. 12:1998;111-120.
4. Tanaka Y, Mizokami M, Orito E, Ohno T, Nakano T, Kato T, et al. New genotypes of TT virus (TTV) and a genotyping assay based on restriction fragment length polymorphism. FEBS Lett. 1999;. (in press).
5. Takahashi K, Hoshino H, Ohta Y, Yoshida N, Mishiro S. Very high prevalence of TT virus (TTV) infection in general population of Japan revealed by a new set of PCR primers. Hepatol Res. 12:1998;233-239.
6. Simmonds P, Davidson F, Lycett C, Prescott LE, MacDonald DM, Ellender J, et al. Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet. 352:1998;191-195.
7. Charlton M, Adjei P, Poterucha J, Zein N, Moore B, Therneau T, et al. TT-virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis. Hepatology. 28:1998;839-842.
8. Naoumov NV, Petrova EP, Thomas MG, Williams R. Presence of a newly described DNA virus (TTV) in patients with liver disease. Lancet. 352:1998;194-197.
9. Prescott LE, Simmonds P. Global distribution of transfusiontransmitted virus. N Engl J Med. 339:1998;776-777.
10. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, et al. Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis. J Med Virol. 56:1998;128-132.
11. Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon SC, Trepo C, et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. N Engl J Med. 339:1998;1493-1499.
12. Davis GL, Lau JYN, Urdea MS, Nauwald PD, Wilber JC, Lindsay K, et al. Quantitative detection of hepatitis C virus RNA with a solid phase signal amplification method: definition of optimal conditions for specimen collection and clinical applications in interferon-treated patients. Hepatology. 19:1994;1337-1341.
13. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1:1981;431-435.
14. Lau JYN, Davis GL, Prescott LE, Maertens G, Lindsay KL, Qian KP, et al. Distribution of hepatitis C virus genotypes determined by line probe assay in patients with chronic hepatitis C seen at tertiary referral centers in the United States. Ann Intern Med. 124:1996;868-876.