Recognizing abnormal marker results that do not reflect disease in patients with germ cell tumors

Journal of Urology

Volumn 163, Issue 3, 2000, Pages 796-801

  Morris, Michael J ^a,b   Bosl, George J ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NONE

Author keywords

Alpha fetoproteins; Chorionic gonadotropin, beta subunit, human; Neoplasms, germ cell and embryonal; Testicular neoplasms; Tumor markers, biological

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN; TUMOR MARKER;

ARTICLE; CANCER REGRESSION; CLINICAL ARTICLE; CORRELATION FUNCTION; DISEASE MARKER; GERM CELL TUMOR; HORMONE BLOOD LEVEL; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 0033965265     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)67807-X     Document Type: Article

References (14)

1. International Germ Cell Cancer Collaborative Group: International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol, 15: 594, 1997
2. Bosl, G. J., Geller, N. L., Cirrincione, C. et al: Multivariate analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res, 43: 3403, 1983
3. Toner, G. C., Geller, N. L., Tan, C. et al: Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors. Cancer Res, 50: 5904, 1990
4. Gerl, A., Lamerz, R., Clemm, C. et al: Does serum tumor marker half-life complement pretreatment risk stratification in metastatic nonseminomatous germ cell tumors? Clin Cancer Res, 2: 1565, 1996
5. Doherty, A. P., Bower, M. and Christmas, T. J.: The role of tumour markers in the diagnosis and treatment of testicular germ cell cancers. Br J Urol, 79: 247, 1997
6. Breborowicz, J.: Microheterogeneity of human alphafetoprotein. Tumour Biol, 9: 3, 1988
7. Saraswathi, A. and Malati, T.: Clinical relevance of alphafetoprotein microheterogeneity in alphafetoprotein-secreting tumors. Cancer Detect Prev, 18: 447, 1994
8. Mora, J., Gascon, J., Tabernero, J. M. et al: Alpha-fetoprotein-concanavalin. A binding as a marker to discriminate between germ cell tumours and liver diseases. Eur J Cancer 31A: 2239, 1995
9. Catalona, W. J., Vaitukaitis, J. L. and Fair, W. R.: Falsely positive specific human chorionic gonadotropin assays in patients with testicular tumors: conversion to negative with testosterone administration. J Urol, 122: 126, 1979
10. Odell, W. D. and Griffin, J.: Pulsatile secretion of human chorionic gonadotropin in normal adults. N Engl J Med, 317: 1688, 1987
11. Fowler, J. E., Jr., Platoff, G. E., Kubrock, C. A. et al: Commercial radioimmunoassay for beta subunit of human chorionic gonadotropin: falsely positive determinations due to elevated serum luteinizing hormone. Cancer, 49: 136, 1982
12. Petersen, P. M., Giwercman, A., Skakkebaek, N. E. et al: Gonadal function in men with testicular cancer. Semin Oncol, 25: 224, 1998
13. Leitner, S. P., Bosl, G. J. and Bajorunas, D.: Gonadal dysfunction in patients treated for metastatic germ-cell tumors. J Clin Oncol, 4: 1500, 1986
14. Bayer, Inc. Technicon Immuno 1 System Information. Publication No. DA4-1159J95, 1995