Transcriptional regulation of E2F-1 and eIF-2 genes by α-Pal: A potential mechanism for coordinated regulation of protein synthesis, growth, and the cell cycle

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1495, Issue 1, 2000, Pages 51-68

  Efiok, Bassey J S ^a   Safer, Brian ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Apoptosis; Cell cycle; E2F 1; Pal

Indexed keywords

INITIATION FACTOR 1; INITIATION FACTOR 2; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIVISION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ERYTHROLEUKEMIA CELL; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; HUMANS; NUCLEAR RESPIRATORY FACTOR 1; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EUKARYOTA;

EID: 0033960025     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(99)00138-X     Document Type: Article

References (53)

1. Swann G.W. The control of cell division. Cancer Res. 17:1957;727-737.
2. Johnston G.C., Pringle J.R., Hartwell L.R. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Exp. Cell Res. 105:1977;79-98.
3. Popolo L., Vanoni M., Alberghina L. Control of the yeast cell cycle by protein synthesis. Exp. Cell Res. 142:1982;69-78.
4. B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, J.D. Watson, The cell division cycle, in: Molecular Biology of The Cell, 3rd edn., Garland Publishing, New York, NY, 1994, pp. 864-906 (cell cycle); pp. 1056-1060 (development); pp. 1142-1146 (terminal differentiation).
5. Moore S. Kinetic evidence for a critical rate of protein synthesis in the Saccharomyces cerevisiae yeast cell cycle. J. Biol. Chem. 263:1988;9674-9681.
6. Makrides S.C. Protein synthesis and degradation during aging and senescence. Biol. Rev. 58:1983;343-422.
7. C.E. Finch, in; Longevity, Senescence, and the Genome, The University of Chicago Press, Chicago, IL, 1990, pp. 370-373.
8. Johnston L.A. Uncoupling growth from the cell cycle. BioEssays. 20:1998;283-286.
9. Weigmann K., Cohen S.M., Lehner C.F. Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila cdc2 kinase. Development. 124:1997;3555-3563.
10. Pardee A.B. A restriction point for control of animal cell proliferation. Proc. Natl. Acad. Sci. 71:1974;1286-1290.
11. Murray A. Cell cycle checkpoints. Curr. Opin. Cell Biol. 6:1994;872-876.
12. kip1 for restriction point control of fibroblast cell cycle. Science. 272:1996;877-880.
13. Elledge S.J., Harper J.W. Cdk inhibitors: on the threshold of checkpoints and development. Current Opin. Cell Biol. 6:1994;847-852.
14. Aprelikova O., Xiong Y., Liu E.T. Both p16 and p21 families of CDK inhibitors block CDK phosphorylation by the CDK activating kinase. J. Biol. Chem. 270:1995;18195-18197.
15. Raff M.C. Size control: che regulation of cell numbers in animal development. Cell. 86:1996;173-175.
16. Lam E.W.-F., Thangue N.A.L. DP and E2F proteins: coordinating transcription with cell cycle progression. Curr. Opin. Cell Biol. 6:1994;859-866.
17. Cobrink D. Regulatory interactions among E2Fs and cell cycle control proteins. Curr. Top. Microbiol. Immunol. 208:1996;31-61.
18. DeGregori J., Gustavo L., Miron A., Jakoi L., Nevins R. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl. Acad. Sci. USA. 94:1997;7245-7250.
19. Slansky J.E., Farnham P.J. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208:1996;1-30.
20. Hsieh J.-K., Fredersdorf S., Kouzarides T., Martin K., Lu X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11:1997;1840-1852.
21. Phillips A.C., Bates S., Ryan K.M., Helin K., Vousden K.H. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11:1997;1853-1863.
22. Yamasaki L., Jacks T., Bronson R., Goillot E., Harlow E., Dyson N.J. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 85:1996;537-548.
23. Yamasaki L., Bronson R., Williams B.O., Dyson N.J., Harlow E., Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the life span of RB(+/-) mice. Nat. Genet. 18:1998;360-364.
24. Fields S.J., Tsai F.-Y., Kuo F., Zubiaga A.M., Kaelin W.G. Jr., Livingstone D.M., Orkin S.H., Greenberg M.E. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 85:1996;549-561.
25. Jagus R., Anderson W.F., Safer B. The regulation of initiation of mammalian protein synthesis. Prog. Nucleic Acids Res. Mol. Biol. 25:1981;127-185.
26. Safer B., Jagus R. The regulation of eIF-2 function in protein synthesis initiation. Biochimie. 63:1981;709-717.
27. Haro C.D., Mendez R., Santoyo J. The eIF-2α kinases and the control of protein synthesis. FASEB J. 10:1996;1378-1387.
28. 1. Cell. 44:1986;391-400.
29. Katze M.G., Detjen B.M., Safer B., Krug R.M. Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol. Cell. Biol. 6:1986;1741-1750.
30. Duncan R., Hershey J.W.B. Regulation of initiation factors during transcriptional repression caused by serum depletion. J. Biol. Chem. 260:1985;5486-5492.
31. Cohen R.B., Boal T.R., Safer B. Increased eIF-2α expression in mitogen-activated primary T lymphocytes. EMBO J. 9:1990;3831-3837.
32. Rosenwald I.B., Rhoads D.B., Callanan L.D., Isselbacher K.J., Schmidt I.V. Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. Proc. Natl. Acad. Sci. USA. 90:1993;6175-6178.
33. Efiok B.J.S., Chiorini J.A., Safer B. A key transcription factor for eukaryotic initiation factor-2α is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J. Biol. Chem. 269:1994;18921-18930.
34. Calzone F.J., Hoog C., Teplow D.B., Cutting A.E., Zeller R.W., Britten R.J., Davidson E.H. Gene regulatory factors of the Sea Urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA binding protein. Dev. 122:1991;335-350.
35. DeSimone S.M., White K. The Drosophila erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the Sea Urchin P3A2 DNA binding protein. Mol. Cell. Biol. 13:1993;3641-3649.
36. Jacob W.F., Silverman T.A., Cohen R.B., Safer B. Identification and characterization of a novel transcription factor participating in the expression of eIF-2α J. Biol. Chem. 264:1989;20372-20384.
37. Johnson D.G., Ohtani K., Nevins J.R. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8:1994;1514-1525.
38. Chiorini J.A., Miyamoto S., Harkin S.J., Safer B. Genomic cloning and characterization of the human eukaryotic initiation factor-2β promoter. J. Biol. Chem. 274:1999;4195-4201.
39. F.M. Ausbel, B. Rogers, R. Kingston, D. More, J. Seidman, J. Smith, K. Struhl, Current Protocols in Molecular Biology, John Wiley and Sons, New York, NY, 1989, pp. 4.9.1-4.9.12 and 10.8.1-10.8.14.
40. Dignan D., Libovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1488.
41. Kitamura T., Tange T., Terasawa T., Chiba S., Kuwaki T., Miyakawa K., Piao Y.-F., Miyazono K., Urabe A., Takaku F. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3 or erythropoietin. J. Cell. Physiol. 140:1989;323-334.
42. Adams P.D., Kaelin W.G. Jr. The cellular effects of E2F overexpression. Curr. Top. Microbiol. Immunol. 208:1996;79-93.
43. Johnson D.G., Schwarz J.K., Cress W.D., Nevins J.R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 365:1993;349-352.
44. Qin X.-Q., Livingston D.M., Kaelin W.G., Adams P.D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA. 91:1994;10918-10922.
45. Shan B., Lee W. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:1994;8166-8173.
46. Kowalik T.F., DeGregory J., Schwarz J.K., Nevins J. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69:1995;2491-2500.
47. Neuman E., Flemington E.K., Sellers W.R., Kaelin W.G. Jr. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14:1994;6607-6615.
48. Sidle A., Palaty C., Derks P., Wiggan O., Kiess M., Gill R.M., Wong A.K., Hamel P.A. Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation. Crit. Rev. Biochem. Mol. Biol. 31:1996;237-271.
49. Slansky J.E., Li Y., Kaelin W.G., Farnham P.J. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13:1993;1610-1618.
50. Dimri G.P., Hara E., Campisi J. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269:1994;16180-16186.
51. Good L., Dimri G.P., Campisi J., Chen K.Y. Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J. Cell Physiol. 168:1996;580-588.
52. 1 cell state. Mol. Cell. Biol. 16:1996;6965-6976.
53. Corbeil H.B., Whyte P., Branton P.E. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene. 11:1995;909-916.