Waxy corn starch: A potent cofiller in pellets produced by extrusion- spheronization

Pharmaceutical Development and Technology

Volumn 5, Issue 1, 2000, Pages 67-76

  Junnila, Riitta ^a,c   Palviainen, Päivi ^a   Heinämäki, Jyrki ^a   Myllärinen, Päivi ^b   Forssell, Pirkko ^b   Yliruusi, Jouko ^a  

^a Division of Pharmaceutical Chemistry   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c Kolari Health Centre   (Finland)

Author keywords

Corn starch; Extrusion; Pellets; Shape; Size; Spheronization; Waxy filler; Waxy maize starch

Indexed keywords

DILUENT; FILLER; STARCH;

ARTICLE; CORN; DRUG MANUFACTURE; IMAGE ANALYSIS; PELLET EXTRUSION; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPHERONIZATION; STRUCTURE ANALYSIS;

CELLULOSE; EXCIPIENTS; LACTOSE; MICROSCOPY, ELECTRON, SCANNING; STARCH; SURFACE PROPERTIES; TABLETS; WAXES; ZEA MAYS;

EID: 0033959394     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100100521     Document Type: Article

References (13)

1. R. E. O'Connor, J. Holinez, and J. B. Schwartz, Spheronization I: Processing and evaluation of spheres prepared from commercially available excipients. Am. J. Pharm., 156, 80-87 (1984).
2. R. Junnila, J. Heinämäki, and J. Yliruusi, Effects of surface-active agent on the size, shape and hardness of microcrystalline cellulose-maize starch pellets produced by an extrusion-spheronisation technique. S.T.P. Pharma Sci., 8, 221-226 (1998).
3. N. Visavarungroj, J. Herman, and J. P. Remon, Cross-linked starch as binding agent. Part. 1. Conventional wet granulation. Int. J. Pharm., 59, 73-78 (1990).
4. N. Visavarungroj and J. P. Remon, Crosslinked starch as binding agent. Part 3. Granulation of an insoluble filler, Int. J. Pharm., 69, 43-51 (1991).
5. S. Inghelbrecht, J. P. Remon, P. Fernandes-De-Aguiar, B. Walczak, D. Luc Massart, F. Van De Velde, P. De Baets, H. Vermeersch, and P. De Backer. Instrumentation of a roll compactor and the evaluation of the parameter settings by neural networks, Int. J. Pharm., 148, 103-115 (1997).
6. J. J. M. Swinkels, Sources of starch, its chemistry and physics, in Starch Conversion Technology (G. M. A. van Beynum and J. A. Roels, eds.), Marcel Dekker, Inc., New York and Basel, 1985, pp. 15-46.
7. J. M. V. Blanshard, Starch granule structure and function: a physicochemical approach, in Starch: Properties and Potential (T. Galliard, ed.), John Wiley & Sons, Chichester, New York, Brisbane, Toronto, Singapore, 1987, pp. 16-54.
8. L. Hellén, J. Yliruusi, P. Merkku, and E. Kristoffersson, Process variables of the radial screen extruder: Part III. Shape, surface and flow properties of pellets, Pharm.-Technol. Int., 5, 38-48 (1993).
9. W. R. Morrison, A fast, simple and reliable method for the microdetermination of phosphorus in biological materials. Anal. Biochem., 7, 218-224 (1964).
10. W. R. Morrison, Lipids in cereal starches: a review, J. Cereal Sci., 8, 1-15 (1988).
11. D. F. Erkoboni, Extrusion-spheronization as a granulation technique, in Handbook of Pharmaceutical Granulation Technology (D. F. Parikh, ed.), Marcel Dekker, Inc., New York, Basel, Hong Kong, 1997, pp. 333-368.
12. G. A. Hileman, S. M. Upadrashta, and S. H. Neau, Drug solubility effects on predicting optimum conditions for extrusion and spheronization of pellets, Pharm. Dev. Technol., 2(1), 43-52 (1997).
13. A. M. Juppo, L. Hellén, V. Pullinen-Strander, K. Kalsta, J. Yliruusi, and E. Kristoffersson, Application of mercury porosimetry in evaluation of extrusion-spheronisation process, Eur. J. Pharm. Biopharm., 44, 205-214 (1997).