Analysis of the electrophysiologic effects of short-term oxybutynin on guinea pig and rabbit ventricular cells

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 2, 2000, Pages 334-340

  Jones, Stephen E ^a   Kasamaki, Yuji ^b   Shuba, Lesya M ^a   Ogura, Toshitsugu ^a   McCullough, John R ^c   McDonald, Terence F ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NIHON UNIVERSITY   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Guinea pig; Oxybutynin; Ventricular cells

Indexed keywords

OXYBUTYNIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG BLOOD LEVEL; GUINEA PIG; HEART ELECTROPHYSIOLOGY; MEMBRANE CURRENT; MUSCLE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; REPOLARIZATION; URINE INCONTINENCE;

ACTION POTENTIALS; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART VENTRICLES; MALE; MANDELIC ACIDS; MEMBRANE POTENTIALS; PAPILLARY MUSCLES; PARASYMPATHOLYTICS; PERFUSION; POTASSIUM; RABBITS; TIME FACTORS;

EID: 0033958909     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200002000-00024     Document Type: Article

References (4)

1. Lish PM, Labudde JA, Peters EL, Robbins SI. Oxybutynin - a musculotropic antispasmodic drug with moderate anticholinergic action. Arch Int Pharmacodyn Ther 1965;156:467-88.
2. Fredericks CM, Anderson GF, Kreulen DL. A study of the anticholinergic and antispasmodic activity of oxybutynin (Ditropan) on rabbit detrusor. Invest Urol 1975;12:317-9.
3. Tonini M, Rizzi CA, Perucca E, et al. Depressant action of oxybutynin on the contractility of intestinal and urinary tract smooth muscle. J Pharm Phannacol 1987;39:103-7.
4. Yarker YE, Goa KL, Fitton A. Oxybutynin: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging 1995;6:243-62.