The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo

Regional Anesthesia and Pain Medicine

Volumn 25, Issue 1, 2000, Pages 52-59

  Kohane, Daniel S ^a,c,g,h   Lu, Nu T ^a   Gökgöl Kline, Arman C ^a   Berde, Charles B ^a,f,g   Shubina, Maria ^b   Kuang, Yu ^c   Hall, Sherwood ^d   Strichartz, Gary R ^e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f Departments of Cardiology and Anesthesia   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

ED50; LD50; Local anesthetic; Peripheral nerve; Saxitoxin; Sciatic; Tetrodotoxin

Indexed keywords

NEOSAXITOXIN; SAXITOXIN; SODIUM CHANNEL; TETRODOTOXIN;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; LOCAL ANESTHESIA; MALE; NERVE BLOCK; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

EID: 0033958768     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1098-7339(00)80011-5     Document Type: Article

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