Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans

British Journal of Anaesthesia

Volumn 84, Issue 2, 2000, Pages 155-162

  Gottrup, H ^a   Hansen, P O ^a,b   Arendt Nielsen, L ^c   Jensen, T S ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

Author keywords

Anaesthetics i.v., ketamine; Anaesthetics local, lidocaine; Complications, hyperalgesia; Pain, experimental; Pain, mechanism; Pharmacology, capsaicin

Indexed keywords

CAPSAICIN; KETAMINE; LIDOCAINE;

ALLODYNIA; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUNKENNESS; EUPHORIA; HEART PALPITATION; HEAT TOLERANCE; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; MALE; MUSCLE RELAXATION; NAUSEA; NORMAL HUMAN; PAIN THRESHOLD; PARESTHESIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; VERTIGO; VISUAL IMPAIRMENT; XEROSTOMIA;

EID: 0033958434     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.bja.a013396     Document Type: Article

References (44)

1. Lindblom U, Verrillo RT. Sensory functions in chronic neuralgia. J Neurol Neurosurg Psychiatry 1979; 42: 422-35
2. Ochoa JL, Yarnitsky D. Mechanical hyperalgesia in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 1993; 33: 465-72
3. Bennett GJ. Neuropathic pain. In: Wall PD, Melzack R, eds. Textbook of Pain. Edinburgh: Churchill Livingstone, 1994; 201-24
4. Jensen TS. Mechanisms of neuropathic pain. In: Campbell JN, eds. Pain 1996 - on Updated Review. Seattle: IASP Press, 1996; 77-86
5. LaMotte RH, Shain CN, Simone DA, Tsai EFP. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 1991; 66: 190-211
6. Koltzenburg M, Lundberg LER, Torebjörk HE. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 1992; 51: 207-19
7. Kilo S, Schmelz M, Koltzenburg M, Handwerker HO. Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain 1994; 117: 385-96
8. Torebjörk HE, Lundberg LER, LaMotte RH. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 1992; 448: 765-80
9. Gottrup H, Nielsen J, Arendt-Nielsen L, Jensen TS. The relationship between sensory thresholds and mechanical hyperalgesia in nerve injury. Pain 1998; 75: 321-9
10. Kenins P. Responses of single nerve fibers to capsaicin applied to the skin. Neurosci Lett 1982; 29: 83-8
11. Simone DA, Baumann TK, LaMotte RH. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain 1989; 38: 99-107
12. Woolf CJ, Thompson SWN. The induction and maintenance of central sensitisation is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 1991; 44: 293-9
13. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-85
14. Carlton SM, Hargett GL, Coggeshall RE. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci Lett 1995; 197: 25-8
15. Zhou S, Bonasera L, Carlton SM. Peripheral administration of NMDA, AMPA or KA results in pain behaviours in rats. NeuroReport 1996; 7: 895-900
16. Warncke T, Jørum E, Stubhaug A. Local treatment with N-methyl-D-aspartate receptor antagonist ketamine inhibits development of secondary hyperalgesia in man by a peripheral action. Neurosci Lett 1997; 227: 1-4
17. Lawand NB, Willis WD, Westlund KN. Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats. Eur J Pharmacol 1997; 324: 169-77
18. Park KM, Max MB, Robinovitz E, Gracely RH, Bennett GJ. Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. Pain 1995; 63: 163-72
19. Andersen OK, Felsby S, Nikolejsen L, Bjerring P, Jensen TS, Arendt-Nielsen L. The effect of ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin - a double-blind, placebo-controlled, human experimental study. Pain 1996; 66: 51-62
20. Ilkjaer S, Petersen KL, Brennum J, Wernberg M, Dahl JB. Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans. Br J Anaesth 1996; 76: 829-34
21. Warncke T, Stubhaug A, Jørum E. Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-injured secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. Pain 1997; 72: 99-106
22. Eide PK, Jørum E, Stubhaug A, Bremnes J, Breivik H. Relief of postherpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain 1994; 58: 347-54
23. Nikolajsen L, Hansen CL, Nielsen J, Keller J, Arendt-Nielsen L, Jensen TS. The effect of ketamine on phantom pain: a neuropathic disorder maintained by peripheral input. Pain 1996; 67: 69-77
24. Felsby S, Nielsen J, Arendt-Nielsen L, Jensen TS. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain 1995; 64: 283-91
25. Max MB, Byas-Smith MG, Gracely RH, Bennett GJ. Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: A double-blind comparison to alfentanil and placebo. Clin Neuropharmacol 1995; 18: 360-8
26. Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitisation in the rat. Anesthesiology 1994; 80: 383-91
27. Sotgui ML, Castagna A, Lacerenza M, Marchettini P. Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in rat model of peripheral neuropathy. Pain 1995; 61: 3-10
28. Chaplan SR, Bach FW, Shafer SL, Yaksh TL. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology 1995; 83: 775-85
29. Bach FW, Jensen TS, Kastrup J, Stigsby B, Dejgard A. The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain 1990; 40: 29-34
30. Kastrup J, Petersen P, Dejgard A. Intravenous lidocaine infusion. A new treatment of chronic diabetic neuropathy. Pain 1987; 28: 69-75
31. Rowbotham MC, Reisner-Keller LA, Fields HL. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 1991; 41: 1024-8
32. Wallace MS, Laitin S, Licht D, Yaksh TL. Concentration-effect relation for intravenous lidocaine infusions in human volunteers. Anesthesiology 1997; 86: 1262-72
33. Simone SA, Baumann TK, Collins JG, LaMotte RH. Sensitisation of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal capsaicin. Brain Res 1989; 486: 185-9
34. Simone DA, Sorkin LS, Oh U, Chung JM, LaMotte RH, Willis WD. Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons. J Neurophysiol 1991; 66: 228-45
35. Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons following C fibre stimulation. Neuropharmacology 1987; 26: 1235-8
36. Nagasaka H, Nagasaka I, Sato I, Matsumoto N, Matsumoto I, Hori T. The effect of ketamine on the excitation and inhibition of dorsal horn WDR neuronal activity induced by bradykinin injection into the femoral artery in cats after spinal cord transection. Anesthesiology 1993; 78: 722-32
37. Devor M, Wall PD, Catalan N. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 1992; 48: 261-8
38. + channels. J Neurophysiol 1994; 72: 349-59
39. Sotgui ML, Biella G, Castagna A, Lacerenza M, Marchettni P. Different time-courses of iv lidocaine effect on ganglionic and spinal units in neuropathic rats. NeuroReport 1994; 5: 873-6
40. Woolf CJ, Wiesenfeld-Hallin Z. The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain 1985; 23: 361-74
41. Darrell LT, MacIver MB. Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury. Anesthesiology 1991; 74: 934-6
42. Lindström P, Lindblom U. The analgesic effect of tocainide in trigeminal neuralgia. Pain 1987; 28: 45-50
43. Dejgard A, Petersen P, Kastrup J. Mexiletine for treatment of chronic diabetic neuropathy. Lancet 1988; 1: 9-11
44. Brose WG, Cousins MJ. Subcutaneous lidocaine for treatment of neuropathic cancer pain. Pain 1991; 45: 145-8