Testosterone and estrogen affect neuronal differentiation but not proliferation in early embryonic cortex of the rat: The possible roles of androgen and estrogen receptors

Neuroscience Letters

Volumn 281, Issue 1, 2000, Pages 57-60

  Zhang, Lei ^a   Chang, Yoong H ^b   Barker, Jeffery L ^b   Hu, Qian ^b   Zhang, Li ^b   Maric, Dragan ^b   Li, Bing Sheng ^b   Rubinow, David R ^a  

^a Building 36   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Cortex; Differentiation; Estrogen; Proliferation; Sexual dimorphism; Testosterone

Indexed keywords

ESTRADIOL; ESTROGEN; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; HORMONE ACTION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ANDROGENS; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ESTRADIOL; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; TESTOSTERONE;

EID: 0033956908     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00942-8     Document Type: Article

References (16)

1. Arai Y., Murakami S., Nishizuka M. Androgen enhances neuronal degeneration in developing preoptic area: apoptosis in the anteroventral periventricular nucleus (AVPvN-POA). Horm. Behav. 28:1994;313-319.
2. Behl C. Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease. Cell Tissue Res. 290:1997;471-480.
3. Breedlove S.M. Sex on the brain. Nature. 389:1997;801-801.
4. Brinton R.D., Tran J., Proffitt P., Montoya M. 17 beta-estradiol enhances the outgrowth and survival of neocortical neurons in culture. Neurochem. Res. 22:1997;1339-1351.
5. Brooks B.P., Merry D.E., Paulson H.L., Lieberman A.P., Kolson D.L., Fischbeck K.H. A cell culture model for androgen effects in motor neurons. J. Neurochem. 70:1998;1054-1060.
6. Chowen J.A., Torres-Aleman I., Garcia-Segura L.M. Trophic effects of estradiol on fetal-rat hypothalamic neurons. Neuroendocrinology. 56:1992;895-901.
7. Garcia-Segura L.M., Cardona-Gomez P., Naftolin F., Chowen J.A. Estradiol upregulates Bcl-2 expression in adult brain neurons. Neuroendocrinology. 9:1998;593-597.
8. Goldstein L.A., Kurz E.M., Sengelaub D.R. Androgen regulation of dendritic growth and retraction in the development of a sexually dimorphic spinal nucleus. J. Neurosci. 10:1990;935-946.
9. Houtsmuller E.J., De Jong F.H., Rowland D.L., Slob A.K. Plasma testosterone in fetal rats and their mothers on day 19 of gestation. Physiol. Behav. 57:1995;495-499.
10. Hutchison J.B., Wozniak A., Beyer C., Karolczak M., Hutchison R.E. Steroid metabolizing enzymes in the determination of brain gender. J. Steroid Biochem. Mol. Biol. 69:1999;85-96.
11. Lauber M.E. Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones. Endocrinology. 137:1996;2718-2730.
12. Lustig R. Sex hormone modulation of neural development in vitro. Horm. Behav. 28:1994;383-395.
13. MacLusky N.J., Clark A.S., Naftolin F., Goldman-Rakic P.S. Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of hippocampus and neocortex. Steroids. 50:1987;459-474.
14. McEwen B.S. Steroid hormones: effect on brain development and function. Horm. Res., Suppl. 3:1992;1-10.
15. Teixeira C., Reed J.C., Pratt M.A. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res. 55:1995;3902-3907.
16. Watters J.J., Campbell J.S., Cunningham M.J., Krebs E.G., Dorsa D.M. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology. 138:1997;4030-4033.