Structural elucidation of an uncommon phenylethylamine analogue in urine responsible for discordant amphetamine immunoassay results

Journal of Analytical Toxicology

Volumn 24, Issue 1, 2000, Pages 17-21

  Marson, C ^a   Schneider, S ^a   Meys, F ^a   Wennig, R ^a  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHOXYAMPHETAMINE; AMPHETAMINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG URINE LEVEL; FLUORESCENCE POLARIZATION IMMUNOASSAY; GAS CHROMATOGRAPHY; IMMUNOASSAY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

AMPHETAMINE; AMPHETAMINES; CROSS REACTIONS; DESIGNER DRUGS; FLUORESCENCE POLARIZATION IMMUNOASSAY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; IMMUNOASSAY; PHENETHYLAMINES;

EID: 0033956839     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/24.1.17     Document Type: Article

References (20)

1. P. Chan, J.H. Chen, M.H. Lee, and J.F. Deng. Fatal and nonfatal methamphetamine intoxication in the intensive care unit. J. Toxicol. Clin. Toxicol. 32: 147-155 (1994).
2. R.C. Baselt and R.H. Cravey. Disposition of Toxic Drugs and Chemicals in Man, 4th ed. Chemical Toxicology Institute, Foster City, CA, 1995, pp 44-47.
3. R.C. Baselt and R.H. Cravey. Disposition of Toxic Drugs and Chemicals in Man, 4th ed. Chemical Toxicology Institute, Foster City, CA, 1995, pp 506-509.
4. J.A. Henry, K.J. Jeffreys, and S. Dawling. Toxicity and deaths from 3,4-methylene-dioxymethamphetamine. Lancet 340: 384-387 (1992).
5. A. Shulgin and A. Shulgin. PIHKAL, D. Joy, Ed. Transform Press, Berkeley, CA, 1991, pp 453-923.
6. T. Kraemer and H.H. Maurer. Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine. J. Chromatogr. B 713: 163-187 (1998).
7. Amphetamines and designer drugs. In Ellenhorn’s Medical Toxicology, 2nd ed., M.J. Ellenhorn, Ed. Williams and Wilkins, Baltimore, MD, 1997, pp 340-355.
8. Central nervous system stimulants. In Comprehensive Review in Toxicology for Emergency Clinicians, 3rd ed., P.D. Bryson, Ed. Taylor and Francis, Washington, D.C., 1997, pp 482-495.
9. E. Meyer, J.F. Van Bocxlaer, W.E. Lambert, L. Thienpont, and A.P. De Leenheer. α-Phenylethylamine identified in judicial samples. Forensic Sci. Int. 76: 159-160 (1995).
10. E. Meyer, J.F. Van Bocxlaer, W.E. Lambert, L. Thienpont, and A.P. Leenheer. Identification of α-phenylethylamine in judicial samples. J. Anal. Toxicol. 20: 116-120 (1996).
11. J.F. Van Bocxlaer, W.E. Lambert, L. Thienpont, and A.P. De Leenheer. Quantitative determination of amphetamine and α-phenylethylamine enantiomers in judicial samples using capillary gas chromatography. J. Anal. Toxicol. 21: 5-11 (1997).
12. C.C. Clark. Drug Enforcement Administration, Miami, FL. Personal communication, 1993.
13. H. Trauer and F. Schuster. N-Methyl-1-phenylethylamin in Ecstasy-Tabletten. Toxichem + Krimtech 65: 2-3 (1998).
14. L.A. King, A.J. Poortman-van der Meer, and H. Huizer. 1-Phenylethylamines: a new series of illicit drugs. Forensic Sci. Int. 77: 141-149 (1996).
15. E. Grana and L. Lilla. The inhibition of amine oxidase and the central stimulating action of the stereoisomeric amphetamines and 1-phenylethylamines. Brit. J. Pharmacol. 14: 501-504 (1959).
16. F.T. Noggle, C.R. Clark, C.L. McMillian, and J. DeRuiter. Liquid chromatographic and mass spectral analysis of N-substituted analogues of 4-methoxyamphetamine. J. Chromatogr. Sci. 27: 607-611 (1989).
17. A. Shulgin and A. Shulgin. PIHKAL, D. Joy, Ed. Transform Press, Berkeley, CA, 1991, pp 783-784.
18. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Pesticides, Pollutants and their Metabolites, 2nd ed., C. Dyllick-Brenzinger, Ed. VCH Verlagsgesellschaft, Weinheim, Germany, 1992, p 1083.
19. R.T. Coutts, G.R. Jones, A. Benderly, and A.L.C. Mak. A note on the synthesis and gas chromatographic-mass spectrometric properties of N-(trimethylsilyl)-acetate of amphetamine and analogs. J. Chromatogr. Sci. 17: 350 (1979).
20. P. Roesner. LKA Schleswig-Holstein, Germany. Personal communication, 1998.