Women at altitude: Carbohydrate utilization during exercise at 4,300 m

Journal of Applied Physiology

Volumn 88, Issue 1, 2000, Pages 246-256

  Braun, Barry ^a,f   Mawson, Jacinda T ^a   Muza, Stephen R ^b   Dominick, Shannon B ^a   Brooks, George A ^c   Horning, Michael A ^c   Rock, Paul B ^b   Moore, Lorna G ^d   Mazzeo, Robert S ^e   Ezeji Okoye, Steven C ^a   Butterfield, Gail E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Gender differences; Glucose flux; Hypobaric hypoxia; Menstrual cycle; Ovarian hormones; Stable isotope; Substrate utilization

Indexed keywords

GLUCOSE;

ADULT; ALTITUDE; ARTICLE; CARBOHYDRATE INTAKE; ENERGY EXPENDITURE; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG GAS EXCHANGE; MENSTRUAL CYCLE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0033954437     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.1.246     Document Type: Article

References (42)

1. Amiel, S. A., A. Maran, J. K. Powrie, A. M. Umpleby, and I.A. Macdonald. Gender differences in counterregulation to hypoglycemia. Diabetologia 36: 460-464, 1993.
2. Bonen, A., F. J. Haynes, W. Watson-Wright, M. M. Sopper, G. N. Pierce, M. P. Low, M. P., and T. E. Graham. Effects of menstrual cycle on metabolic responses to exercise. J. Appl. Physiol. 55: 1506-1513, 1988.
3. Braun, B., G. E. Butterfield, S. B. Dominick, S. Zamudio, R. G. McCullough, P. B. Rock, and L. G. Moore. Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle. J. Appl. Physiol. 85: 1966-1973, 1998.
4. Braun, B., and S. B. Dominick. Women at altitude: substrate utilization during rest and exercise. In: Hypoxia and Mountain Medicine, edited by C. Houston and J. Coates. Burlington, VT: Queen City, 1997, p. 20-34.
5. Brooks, G. A. Increased glucose dependency in circulatory compensated hypoxia. In: Hypoxia and Mountain Medicine, C. Houston and J. Coates. Burlington, VT: Queen City, 1992, p. 213-226.
6. Brooks, G. A., and G. E. Butterfield. Metabolic response of lowlanders to high altitude exposure: malnutrition versus the effect of hypoxia. In: High Altitude, edited by T. Hornbein and R. Schoene. New York: Dekker. In press.
7. Brooks, G. A., G. E. Butterfield, R. R. Wolfe, B. M. Groves, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and J. T. Reeves. Increased dependence on blood glucose after acclimatization to 4,300 m. J. Appl. Physiol. 70: 919-927, 1991.
8. Brooks, G. A., and J. Mercier. The balance of carbohydrate and lipid utilization during exercise: the crossover concept. J. Appl. Physiol. 76: 2253-2261, 1994.
9. Bunt, J. C. Metabolic actions of estradiol: significance for acute and chronic exercise responses. Med. Sci. Sports Exerc. 22: 286-290, 1990.
10. Butterfield, G. E., J. Gates, S. Fleming, G. A. Brooks, J. R. Sutton, and J. T. Reeves. Increased energy intake minimizes weight loss at high altitude. J. Appl. Physiol. 72: 1741-1748, 1992.
11. Cartee, G. D., A. G. Douen, T. Ramlal, A. Klip, and J. O. Holloszy. Stimulation of glucose transport in skeletal muscle by hypoxia. J. Appl. Physiol. 70: 1593-1600, 1991.
12. Davis, S. N., A. D. Cherrington, R. E. Goldstein, J. Jacobs, and L. Price. Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am. J. Physiol. Endocrinol. Metab. 265: E680-E689, 1993.
13. Flatt, J. P. The biochemistry of energy expenditure. In: Obesity Research II, edited by G. Bray. London: Newman, 1978, p. 211-228.
14. Friedlander, A. L., G. A. Casazza, M. A. Horning, M. J. Huie, M. F. Piacentini, J. K. Trimmer, and G. A. Brooks. Training-induced adaptations of carbohydrate metabolism in women: women respond differently from men. J. Appl. Physiol. 85: 1175-1186, 1998.
15. Friedmann, B., and W. Kindermann. Energy metabolism and regulatory hormones in women and men during endurance exercise. Eur. J. Appl. Physiol. 59: 1-9, 1989.
16. Godsland, I. F. The influence of female sex steroids on glucose metabolism and insulin action. J. Intern. Med. 240, Suppl. 738: 1-60, 1996.
17. Green, H. J. Muscular adaptations at extreme altitude: metabolic implications during exercise. Int. J. Sports Med. 13: 163-165, 1992.
18. Hackney, A. C. Effect of the menstrual cycle on resting muscle glycogen content. Horm. Metab. Res. 22: 647-653, 1992.
19. Hannon, J. P., G. J. Klain, D. M. Sudman, and F. J. Sullivan. Nutritional aspects of high-altitude exposure in women. Am. J. Clin. Nutr. 29: 604-613, 1976.
20. Hochachka, P. W. Exercise limitations at high altitude: the metabolic problem and search for its solution. In: Circulation, Respiration, and Metabolism, edited by R. Gilles. Berlin-Heidelberg: Springer-Verlag, 1985, p. 240-249.
21. Holden, J. E., C. K. Stone, C. M. Clark, W. D. Brown, R. J. Nickles, C. Stanley, and P. W. Hochachka. Enhanced cardiac metabolism of plasma glucose in high altitude natives: adaptation against chronic hypoxia. J. Appl. Physiol. 79: 222-228, 1995.
22. Horton, T. J., M. J. Pagliassotti, K. Hobbs, and J. O. Hill. Fuel metabolism in males and females during and following long-duration exercise. J. Appl. Physiol. 85: 1823-1832, 1998.
23. Jequier, E. Direct and indirect calorimetry in man. In: Substrate and Energy Metabolism, edited by J. S. Garrow and D. Halliday. London: Libbey, 1985, p. 82-92.
24. Larsen, J. J., J. M. Hansen, N. V. Olsen, H. Galbo, and F. Dela. The effect of altitude hypoxia on glucose homeostasis in humans. J. Physiol. (Lond.) 514: 241-249, 1997.
25. Matute, M. L., and R. K. Kalkhoff. Sex steroid influence on hepatic gluconeogenesis and glycogen formation. Endocrinology 92: 762-766, 1973.
26. Mawson, J. T., B. Braun, P. B. Rock, L. G. Moore, R. S. Mazzeo, and G. E. Butterfield. Women at altitude: energy requirement at 4,300 m. J. Appl. Physiol. 88: 272-281, 2000.
27. Mazzeo, R. S., P. R. Bender, G. A. Brooks, G. E. Butterfield, B. M. Groves, J. R. Sutton, E. E. Wolfel, and J. T. Reeves. Arterial catecholamine response during exercise with acute and chronic high-altitude exposure. Am. J. Physiol. Endocrinol. Metab. 261: E419-E424, 1991.
28. Mazzeo, R. S., A. Child, G. E. Butterfield, J. T. Mawson, S. Zamudio, and L. G. Moore. Catecholamine response during 12 days of high altitude exposure in women. J. Appl. Physiol. 84: 1151-1157, 1998.
29. McClelland, G. B., P. W. Hochachka, and J.-M. Weber. Carbohydrate utilization during exercise after high-altitude acclimation: a new perspective. Proc. Natl. Acad. Sci. USA 95: 10288-10293, 1998.
30. Roberts, A. C., G. E. Butterfield, A. Cymerman, J. T. Reeves, E. E. Wolfel, and G. A. Brooks. Acclimatization to 4300 meters altitude decreases reliance on fat as a substrate. J. Appl. Physiol. 81: 1762-1771, 1996.
31. Roberts, A. C., J. T. Reeves, G. E. Butterfield, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and G. A. Brooks. Altitude and β-blockade augment glucose utilization during submaximal exercise. J. Appl. Physiol. 80: 605-615, 1996.
32. Romijn, J. A., E. F. Coyle, S. Sidossis, A. Gastadelli, J. F. Horowitz, E. Endert, and R. R. Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. Endocrinol. Metab. 265: E380-E391, 1993.
33. Ruby, B. C. Substrate utilization in males and females. Sports Med. 17: 393-410, 1994.
34. Ruby, B. C. Gender differences in carbohydrate metabolism: rest, exercise, and post-exercise. In: Gender Differences in Metabolism: Practical and Nutritional Considerations, edited by M. A. Tarnopolsky. Boca Raton, FL: CRC, 1999, p. 121-154.
35. Ruby, B. C., R. A. Robergs, D. L. Waters, M. Burge, C. Mermier, and L. Stolarczyk. Effects of estradiol on substrate turnover during exercise in amenorrheic females. Med. Sci. Sports Exerc. 29: 1160-1167, 1997.
36. Tarnopolsky, M. A. Gender differences in lipid metabolism during exercise and at rest. In: Gender Differences in Metabolism: Practical and Nutritional Considerations, edited by M. A. Tarnopolsky. Boca Raton, FL: CRC, 1999, p. 179-199.
37. Tarnopolsky, M. A., S. A. Atkinson, S. M. Phillips, and J. D. MacDougall. Carbohydrate loading and metabolism during exercise in men and women. J. Appl. Physiol. 78: 1360-1368, 1995.
38. Tarnopolsky, L. J., J. D. MacDougall, S. A. Atkinson, M. A. Tarnopolsky, and J. R. Sutton. Gender differences in substrate for endurance exercise. J. Appl. Physiol. 78: 302-308, 1995.
39. Tate, C. A., and R. W. Holtz. Gender and fat metabolism during exercise: a review. Can. J. Appl. Physiol. 23: 570-582, 1998.
40. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Metabolism. New York: Wiley-Liss, 1992, p. 283-316.
41. Young, A. J., W. J. Evans, A. Cymerman, K. B. Pandolf, J. J. Knapik, and J. T. Maher. Sparing effect of chronic high-altitude exposure on muscle glycogen utilization. J. Appl. Physiol. 52: 857-862, 1982.
42. 2. Am. J. Physiol. Endocrinol. Metab. 266: E921-E929, 1994.